AVP and OXTR

Number of citations of the paper that reports this interaction (PMID 7921229)
0

Data Source:
HPRD (in vivo)

		AVP	OXTR
Gene Name		arginine vasopressin	oxytocin receptor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule Dendrite	Plasma Membrane Integral Component Of Plasma Membrane Microvillus Cell-cell Adherens Junction Apical Plasma Membrane
	Molecular Function	Protein Kinase Activity Signal Transducer Activity Receptor Binding Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity V1A Vasopressin Receptor Binding V1B Vasopressin Receptor Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Oxytocin Receptor Activity Vasopressin Receptor Activity Peptide Hormone Binding Peptide Binding
	Biological Process	Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Homeostasis Generation Of Precursor Metabolites And Energy Protein Phosphorylation Water Transport Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Female Receptivity Circadian Rhythm Grooming Behavior Locomotory Behavior Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Cell Growth Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Positive Regulation Of Peptidyl-serine Phosphorylation Response To Testosterone Response To Nicotine Social Behavior Regulation Of Renal Sodium Excretion Vasoconstriction Hyperosmotic Salinity Response Maternal Behavior Negative Regulation Of Apoptotic Process Penile Erection Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Sodium-independent Organic Anion Transport Response To Ethanol Positive Regulation Of Vasoconstriction Negative Regulation Of Transmission Of Nerve Impulse Transmembrane Transport ERK1 And ERK2 Cascade Protein Kinase C Signaling Negative Regulation Of Release Of Cytochrome C From Mitochondria	Suckling Behavior Response To Amphetamine Regulation Of Systemic Arterial Blood Pressure By Vasopressin Muscle Contraction Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Lactation Memory Positive Regulation Of Norepinephrine Secretion Telencephalon Development Sleep Positive Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Response To Progesterone Cellular Response To Hormone Stimulus Response To Anoxia Response To Cytokine Social Behavior Response To Cocaine Response To Drug Maternal Behavior Sperm Ejaculation Eating Behavior Response To Peptide Hormone Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Digestive Tract Development Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Maternal Process Involved In Parturition Positive Regulation Of Penile Erection Negative Regulation Of Gastric Acid Secretion ERK1 And ERK2 Cascade Positive Regulation Of Uterine Smooth Muscle Contraction Response To Peptide
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Aquaporin-mediated transport SLC-mediated transmembrane transport Transport of organic anions G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Transport of vitamins, nucleosides, and related molecules BMAL1:CLOCK,NPAS2 activates circadian gene expression	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Vasopressin-like receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Oxytocin Carbetocin
Diseases
GWAS			Depression and alcohol dependence ( 22064162)
Protein-Protein Interactions		8 interactors: AVPR1A AVPR1B AVPR2 CRYAB DLX2 KMT2A OXTR TXNDC17	4 interactors: ARRB2 AVP GPRASP1 OXT
Entrez ID		551	5021
HPRD ID		01891	01328
Ensembl ID		ENSG00000101200	ENSG00000180914
Uniprot IDs		P01185	B2R9L7 P30559
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Vasopressin Positive Regulation Of Vasoconstriction Regulation Of Vasoconstriction Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Blood Pressure Regulation Of Blood Pressure Telencephalon Development Sperm Ejaculation Blood Circulation Response To Hormone Positive Regulation Of Systemic Arterial Blood Pressure Forebrain Development Maternal Behavior Response To Peptide Insemination Positive Regulation Of Cytosolic Calcium Ion Concentration Copulation Regulation Of Renal Sodium Excretion Cellular Response To Hormone Stimulus Cytosolic Calcium Ion Homeostasis Regulation Of Excretion Response To Organic Substance Brain Development Social Behavior Head Development Organ Development Response To Organonitrogen Compound Cellular Calcium Ion Homeostasis Chemical Homeostasis Calcium Ion Homeostasis Activation Of Phospholipase C Activity Mating Cellular Response To Organic Substance Positive Regulation Of Phospholipase C Activity Central Nervous System Development Negative Regulation Of Transport Cellular Metal Ion Homeostasis Positive Regulation Of Phospholipase Activity Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cellular Response To Drug Cellular Ion Homeostasis Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Metal Ion Homeostasis Response To Steroid Hormone Cellular Chemical Homeostasis System Development Homeostatic Process Response To Estradiol	Maternal Aggressive Behavior Hyperosmotic Salinity Response Aggressive Behavior Positive Regulation Of Ion Transport Regulation Of Female Receptivity Maternal Behavior Negative Regulation Of Release Of Cytochrome C From Mitochondria Female Mating Behavior Grooming Behavior Regulation Of Renal Sodium Excretion Copulation Hyperosmotic Response Regulation Of Excretion Negative Regulation Of Mitochondrion Organization Mating Behavior Response To Salt Stress Positive Regulation Of Blood Pressure Social Behavior Single-organism Behavior Mating Regulation Of Neurological System Process Regulation Of Body Fluid Levels Positive Regulation Of Peptidyl-serine Phosphorylation Behavior Receptor Metabolic Process Regulation Of Ion Transport Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Response To Osmotic Stress Regulation Of Mitochondrion Organization Renal System Process Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Transport Positive Regulation Of Synaptic Transmission Multicellular Organismal Reproductive Process Positive Regulation Of Hindgut Contraction Multicellular Organism Reproduction Regulation Of Anion Transport Response To Alkaloid Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Regulation Of Signaling Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Catabolic Process Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Hindgut Contraction Reproduction Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis
Tagcloud ?		arginine ascending bath ca2 camp car ctal fluxes henle hypotonic isotonic limb lumen medullary mg2 mmol mol mtal nacl net pdte perfusion phospholipase reabsorption segments sensing thick transepithelial vasopressin	accumbens amygdaloid asds autism autistic autoradiography c57bl6 calls circuitry circuits compensative impairments interests intranasal mor mors motivation operates opioidergic opioids oprm1 oxytocin oxytocinergic physiopathology reward social socially ultrasonic
Tagcloud (Difference) ?		arginine ascending bath ca2 camp car ctal fluxes henle hypotonic isotonic limb lumen medullary mg2 mmol mol mtal nacl net pdte perfusion phospholipase reabsorption segments sensing thick transepithelial vasopressin	accumbens amygdaloid asds autism autistic autoradiography c57bl6 calls circuitry circuits compensative impairments interests intranasal mor mors motivation operates opioidergic opioids oprm1 oxytocin oxytocinergic physiopathology reward social socially ultrasonic
Tagcloud (Intersection) ?