PPP1R1A and RNF41

Data Source: HiPPIP (Novel)

		PPP1R1A	RNF41
Name		protein phosphatase 1 regulatory inhibitor subunit 1A	ring finger protein 41
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Glycogen Metabolic Process Signal Transduction Intracellular Signal Transduction	Protein Polyubiquitination Autophagy Apoptotic Process Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		None	Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Body fat mass ( 28552196 ) Hip circumference ( 28552196 ) Waist circumference ( 28552196 )	Asthma ( 31619474 ) Height ( 34054925 )
Novel Interactors		1 novel interactors: RNF41	6 novel interactors: GDF11 NEUROD4 ORMDL2 PPP1R1A SUOX TBATA
Interacting Genes		1 interacting genes: PPP1R15A	39 interacting genes: ADRB2 AIRIM AP2S1 APP ARL6IP4 BIRC6 CLEC9A ERBB3 ERBB4 IRS4 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 RAD23A RFC4 RNF166 RRM2B SRR TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 ZAP70
Entrez ID		5502	10193
HPRD ID		17893	11520
Ensembl ID		ENSG00000135447	ENSG00000181852
Uniprot IDs		Q13522	F8VSB6 Q9H4P4
PDB IDs		Not available	2FZP 2GWF
GO Terms Enriched among Interactors		Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Apoptotic Signaling Pathway Positive Regulation Of Translational Initiation In Response To Stress Eukaryotic Initiation Factor EIF2 Binding Positive Regulation Of Protein Metabolic Process Cell Death Apoptotic Process Negative Regulation Of Mitophagy Endoplasmic Reticulum Tubular Network Programmed Cell Death Protein Phosphatase 1 Binding Protein Phosphatase Activator Activity Regulation Of Translation In Response To Endoplasmic Reticulum Stress Protein Localization To Endoplasmic Reticulum Negative Regulation Of PERK-mediated Unfolded Protein Response Protein Phosphatase Type 1 Complex Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Translation In Response To Stress Regulation Of Translational Initiation In Response To Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Macroautophagy Regulation Of Endoplasmic Reticulum Unfolded Protein Response Protein Phosphatase Regulator Activity Regulation Of Mitophagy Positive Regulation Of Translational Initiation Negative Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Autophagy Of Mitochondrion Receptor Tyrosine Kinase Binding Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Protein Metabolic Process Protein Autoubiquitination	Ubiquitin Conjugating Enzyme Activity Receptor Complex Protein Polyubiquitination Neuregulin Receptor Activity Protein Ubiquitination Melatonin Receptor Activity Post-translational Protein Modification Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Free Ubiquitin Chain Polymerization Protein Modification Process Negative Regulation Of Signal Transduction Amacrine Cell Differentiation Negative Regulation Of Cell Communication Macromolecule Metabolic Process Negative Regulation Of Signaling Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Calcium-mediated Signaling Axon Development Regulation Of Viral Process Ubiquitin-protein Transferase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Regulation Of Amyloid Fibril Formation Protein K63-linked Ubiquitination