PAK1IP1 and TINF2

Number of citations of the paper that reports this interaction (PMID 15316005)
76

Data Source:
BioGRID (two hybrid)

		PAK1IP1	TINF2
Gene Name		PAK1 interacting protein 1	TERF1 (TRF1)-interacting nuclear factor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Plasma Membrane	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Perinucleolar Chromocenter Nuclear Matrix
	Molecular Function		DNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Cell Proliferation Negative Regulation Of Signal Transduction Palate Development	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein ADP-ribosylation Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region
Pathways			Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: PAK1 SMURF1 TINF2	88 interactors: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CTTN DBN1 DCX DHFRL1 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM POT1 PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790
Entrez ID		55003	26277
HPRD ID		07424	16056
Ensembl ID		ENSG00000111845	ENSG00000092330
Uniprot IDs		Q9NWT1	B4DFJ1 Q9BSI4
PDB IDs			3BQO 3BU8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein ADP-ribosylation Cellular Protein Localization Regulation Of Protein ADP-ribosylation Negative Regulation Of Protein Glycosylation Protein Localization Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Telomere Assembly Histone H3-T11 Phosphorylation Positive Regulation Of Organelle Organization Cellular Localization Negative Regulation Of Telomere Maintenance Regulation Of Protein Glycosylation Contact Inhibition Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Glycoprotein Metabolic Process Regulation Of Telomere Maintenance Protein Localization To Cell Surface Negative Regulation Of Cell Proliferation Receptor Catabolic Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hyperosmotic Response Ectoderm Development Regulation Of Glycoprotein Biosynthetic Process Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Protein Export From Nucleus Activation Of JUN Kinase Activity Histone Phosphorylation Chromosome Organization Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Stress Fiber Assembly Peptidyl-threonine Phosphorylation Receptor Clustering Neuromuscular Junction Development Negative Regulation Of DNA Replication Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Stress Fiber Assembly Actin Cytoskeleton Reorganization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity	Negative Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Glycolytic Process Protection From Non-homologous End Joining At Telomere Carbohydrate Catabolic Process Negative Regulation Of DNA Replication Telomere Assembly Catabolic Process Negative Regulation Of DNA Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Catalytic Activity Positive Regulation Of Telomerase Activity Pyruvate Metabolic Process Telomere Maintenance Telomere Maintenance Via Telomerase Pathogenesis Generation Of Precursor Metabolites And Energy Glucose Metabolic Process Positive Regulation Of Single-stranded Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Small Molecule Metabolic Process Organic Acid Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Catalytic Activity Carboxylic Acid Metabolic Process Age-dependent Telomere Shortening Telomeric Loop Formation Nervous System Development Regulation Of Signaling Positive Regulation Of DNA Biosynthetic Process Glycogen Metabolic Process RNA-dependent DNA Replication Nucleoside Metabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Signal Transduction Hexose Metabolic Process Cellular Process Regulation Of DNA Replication Monocarboxylic Acid Metabolic Process Cellular Carbohydrate Metabolic Process Response To Stimulus Protein Localization To Chromosome Organelle Organization Telomere Maintenance Via Telomere Lengthening Polysaccharide Metabolic Process
Tagcloud ?		18s actb ap3d1 bestkeeper c2c12 cdc40 csnk2a2 dystrophic dystrophin exceptionally fbxo38 fbxw2 gapdh genorm h2k2b4 h2ksf1 htatsf1 informative mef2c myoblasts myod myogenesis myogenic myogenin normalization normalizing normfinder packages zfp91	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Difference) ?		18s actb ap3d1 bestkeeper c2c12 cdc40 csnk2a2 dystrophic dystrophin exceptionally fbxo38 fbxw2 gapdh genorm h2k2b4 h2ksf1 htatsf1 informative mef2c myoblasts myod myogenesis myogenic myogenin normalization normalizing normfinder packages zfp91	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Intersection) ?