AUP1 and ITGA5

Number of citations of the paper that reports this interaction (PubMedID 12042322)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AUP1	ITGA5
Description		AUP1 lipid droplet regulating VLDL assembly factor	integrin subunit alpha 5
Image
GO Annotations	Cellular Component	Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane Cytoplasmic Vesicle Extracellular Exosome	Ruffle Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Cytoplasmic Vesicle Ruffle Membrane Integrin Alpha5-beta1 Complex Synapse Postsynaptic Membrane Anchoring Junction Alphav-beta3 Integrin-vitronectin Complex Glutamatergic Synapse
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding	Virus Receptor Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Calcium Ion Binding Protein Binding Signaling Receptor Activity Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Response To Virus Retrograde Protein Transport, ER To Cytosol Lipid Droplet Organization ERAD Pathway Lipophagy Lipid Droplet Formation Protein Localization To Lipid Droplet	Angiogenesis Formation Of Primary Germ Layer Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Female Pregnancy Memory Tissue Development Positive Regulation Of Cell-substrate Adhesion Response To Muscle Activity CD40 Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Regulation Of Angiogenesis Symbiont Entry Into Host Cell Cell-cell Adhesion Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Anoikis
Pathways			Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Signal transduction by L1 RUNX2 regulates genes involved in cell migration GPER1 signaling Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs			Resveratrol Tauroursodeoxycholic acid
Diseases
GWAS			Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		10 interacting genes: GRSF1 ITGA1 ITGA2 ITGA2B ITGA5 ITGAM ITGAV RNF11 UBC UBE2G2	32 interacting genes: ACKR5 ANGPT1 ANGPT2 ANGPTL3 ARHGAP5 AUP1 CD9 CLK1 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GRK6 ITGB1 ITGB3 ITGB5 L1CAM LGALS3BP NISCH PECAM1 RABIF SHARPIN SPP1 STAMBP TNC UBAP1 VCL VTN
Entrez ID		550	3678
HPRD ID		03892	00627
Ensembl ID		ENSG00000115307	ENSG00000161638
Uniprot IDs		Q9Y679	B2R627 P08648
PDB IDs		2EKF 7LEW	3VI3 3VI4 4WJK 4WK0 4WK2 4WK4 7NWL 7NXD 9B9J 9B9K 9CKV
Enriched GO Terms of Interacting Partners?		Integrin Complex Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-substrate Adhesion Signaling Receptor Activity External Side Of Plasma Membrane Cell-cell Adhesion Cell Surface Cell Adhesion Mediated By Integrin Integrin Binding Heterotypic Cell-cell Adhesion Focal Adhesion Cell Adhesion Collagen Binding Involved In Cell-matrix Adhesion Virus Receptor Activity Wound Healing, Spreading Of Epidermal Cells Basal Part Of Cell Symbiont Entry Into Host Cell Biological Process Involved In Interaction With Host Response To Muscle Activity Extracellular Matrix Binding Wound Healing, Spreading Of Cells Endodermal Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell-substrate Junction Assembly Cell-substrate Junction Organization Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Extracellular Exosome Formation Of Primary Germ Layer Entry Into Host Cell By A Symbiont-containing Vacuole Opsonin Binding Angiogenesis Collagen Binding Integrin Alpha1-beta1 Complex Cell Migration Metal Ion Binding Amyloid-beta Binding Female Pregnancy Response To Activity Integrin Alpha5-beta1 Complex Integrin AlphaM-beta2 Complex Specific Granule Membrane Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Integrin Alphav-beta1 Complex Integrin Alphav-beta6 Complex Integrin Alphav-beta8 Complex	Cell Adhesion Integrin Binding Cell-substrate Adhesion Cell-matrix Adhesion Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cell Migration Extracellular Matrix Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Receptor Complex Response To Growth Factor Signal Transduction Cell Adhesion Mediated By Integrin Enzyme-linked Receptor Protein Signaling Pathway Cell Motility Extracellular Exosome Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Response To Wounding Regulation Of ERK1 And ERK2 Cascade Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Extracellular Space Negative Regulation Of Blood Coagulation Cell Junction Organization Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Activity Mesodermal Cell Differentiation Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Extracellular Region Regulation Of Cell-substrate Adhesion Regulation Of Anatomical Structure Morphogenesis Platelet Alpha Granule Membrane Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Wound Healing Regulation Of Cell Population Proliferation
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