AUP1 and RNF11

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)

		AUP1	RNF11
Description		AUP1 lipid droplet regulating VLDL assembly factor	ring finger protein 11
Image			No pdb structure
GO Annotations	Cellular Component	Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane Cytoplasmic Vesicle Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Cytoplasm Endosome Early Endosome Recycling Endosome Extracellular Exosome
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Response To Virus Retrograde Protein Transport, ER To Cytosol Lipid Droplet Organization ERAD Pathway Lipophagy Lipid Droplet Formation Protein Localization To Lipid Droplet	Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways
Drugs
Diseases
GWAS			Atrial fibrillation ( 29290336) Male-pattern baldness ( 28196072) QRS duration ( 21076409)
Interacting Genes		10 interacting genes: GRSF1 ITGA1 ITGA2 ITGA2B ITGA5 ITGAM ITGAV RNF11 UBC UBE2G2	69 interacting genes: AKT1 ANKRD13A ANKRD28 APP ASCC2 AUP1 CALCOCO2 CBLB CCDC127 DCUN1D1 EPN1 EPN2 EPN3 EPS15 ERCC6 FANCL GGA1 GGA2 GGA3 HERC1 HERC2 HUWE1 IKBKG ITCH MYO6 NEDD4 NEDD4L OPTN PDCD6IP POLI PTPRC QARS1 RABGEF1 RIPK1 RNF168 RNF216 RPS27A SDCBP SMURF1 SMURF2 SNRNP70 SPRTN STAM2 STAMBP TAX1BP1 TNFAIP3 TNIP1 TOM1L2 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBQLN2 UBQLN4 USP5 WWP1 WWP2 YAP1 ZFYVE16 ZFYVE9 ZNF350
Entrez ID		550	26994
HPRD ID		03892	09955
Ensembl ID		ENSG00000115307	ENSG00000123091
Uniprot IDs		Q9Y679	Q9Y3C5
PDB IDs		2EKF 7LEW
Enriched GO Terms of Interacting Partners?		Integrin Complex Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-substrate Adhesion Signaling Receptor Activity External Side Of Plasma Membrane Cell-cell Adhesion Cell Surface Cell Adhesion Mediated By Integrin Integrin Binding Heterotypic Cell-cell Adhesion Focal Adhesion Cell Adhesion Collagen Binding Involved In Cell-matrix Adhesion Virus Receptor Activity Wound Healing, Spreading Of Epidermal Cells Basal Part Of Cell Symbiont Entry Into Host Cell Biological Process Involved In Interaction With Host Response To Muscle Activity Extracellular Matrix Binding Wound Healing, Spreading Of Cells Endodermal Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell-substrate Junction Assembly Cell-substrate Junction Organization Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Extracellular Exosome Formation Of Primary Germ Layer Entry Into Host Cell By A Symbiont-containing Vacuole Opsonin Binding Angiogenesis Collagen Binding Integrin Alpha1-beta1 Complex Cell Migration Metal Ion Binding Amyloid-beta Binding Female Pregnancy Response To Activity Integrin Alpha5-beta1 Complex Integrin AlphaM-beta2 Complex Specific Granule Membrane Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Integrin Alphav-beta1 Complex Integrin Alphav-beta6 Complex Integrin Alphav-beta8 Complex	Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Macromolecule Catabolic Process Protein Polyubiquitination Proteolysis Ubiquitin Binding Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Activity Cytosol Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Monoubiquitination Endosome Ubiquitin Ligase Complex Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Negative Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Protein K63-linked Ubiquitination Positive Regulation Of Protein Catabolic Process K63-linked Polyubiquitin Modification-dependent Protein Binding Transferase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Negative Regulation Of Canonical NF-kappaB Signal Transduction Early Endosome Membrane Positive Regulation Of Protein Modification Process Autophagosome Protein-containing Complex Positive Regulation Of Post-translational Protein Modification DNA Damage Response Regulation Of Protein Ubiquitination Cytoplasm Cellular Response To Stress Extracellular Exosome
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