AUP1 and ITGA1

Number of citations of the paper that reports this interaction (PMID 12042322)
6

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		AUP1	ITGA1
Gene Name		ancient ubiquitous protein 1	integrin, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Acrosomal Vesicle Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha1-beta1 Complex Neuron Projection Perikaryon Membrane Raft Basal Part Of Cell Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Receptor Binding Protein Binding Collagen Binding Protein Phosphatase Binding Metal Ion Binding Collagen Binding Involved In Cell-matrix Adhesion
	Biological Process		Activation Of MAPK Activity Muscle Contraction Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Negative Regulation Of Cell Proliferation Extracellular Matrix Organization Neutrophil Chemotaxis Positive Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vasodilation Positive Regulation Of Neuron Apoptotic Process Cellular Extravasation
Pathways			Platelet Adhesion to exposed collagen CHL1 interactions Axon guidance Laminin interactions Semaphorin interactions Other semaphorin interactions Smooth Muscle Contraction L1CAM interactions Integrin cell surface interactions
Drugs
Diseases
GWAS			Alzheimer's disease biomarkers ( 23419831) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Response to platinum-based agents ( 22020760)
Protein-Protein Interactions		7 interactors: ITGA1 ITGA2 ITGA2B ITGA5 ITGAM ITGAV RNF11	10 interactors: AUP1 BIN1 COL13A1 COL8A1 ITGB1 LAMA1 MATN1 PTPN2 SHARPIN TLN1
Entrez ID		550	3672
HPRD ID		03892	01892
Ensembl ID		ENSG00000115307
Uniprot IDs		Q9Y679	P56199
PDB IDs		2EKF	1PT6 1QC5 1QCY 2L8S 4A0Q
Enriched GO Terms of Interacting Partners?		Integrin-mediated Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Blood Coagulation Hemostasis Cell-substrate Adhesion Regulation Of Body Fluid Levels Wound Healing Chemotaxis Response To Wounding Axon Guidance Cell-matrix Adhesion Cell Adhesion Axonogenesis Locomotion Axon Development Cell Morphogenesis Involved In Neuron Differentiation Leukocyte Migration Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Neurogenesis Neuron Projection Development Cell Migration Cell Projection Morphogenesis Positive Regulation Of Cell Migration Cell Part Morphogenesis Positive Regulation Of Cell Motility Cell Development Response To External Stimulus Positive Regulation Of Cellular Component Movement Cell Motility Positive Regulation Of Locomotion Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Nervous System Development Formation Of Primary Germ Layer Cell Adhesion Mediated By Integrin Single Organismal Cell-cell Adhesion Regulation Of Cell Migration Regulation Of Cell Motility Gastrulation Heterotypic Cell-cell Adhesion Regulation Of Locomotion Generation Of Neurons Regulation Of Cellular Component Movement Cellular Extravasation Positive Regulation Of Phosphatase Activity	Cell Differentiation Extracellular Matrix Organization Extracellular Structure Organization System Development Multicellular Organismal Development Anatomical Structure Development Cell Adhesion Developmental Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Organ Development Single Organismal Cell-cell Adhesion Regulation Of Cell Adhesion Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Differentiation Tissue Development Collagen Catabolic Process Cellular Component Assembly Organ Morphogenesis Axon Guidance Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Prolactin Signaling Pathway Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Growth Plate Cartilage Chondrocyte Morphogenesis Negative Regulation Of Interleukin-2-mediated Signaling Pathway Collagen Metabolic Process Cell Morphogenesis Blood Vessel Morphogenesis Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Endocytosis B Cell Differentiation Negative Regulation Of Inflammatory Response Blood Vessel Development Nervous System Development Lipid Tube Assembly Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Positive Regulation Of Cell-substrate Adhesion Cell-cell Junction Assembly Axonogenesis Vasculature Development Bone Morphogenesis Axon Development Formation Of Primary Germ Layer
Tagcloud ?		abundance affects ancient associates conjugating connection cue dislocation droplet droplets endoplasmic engagement facilitates hrd1 impairs involves lipid localizes misfolded physically polyubiquitylation proteasome quality recruit reticulum sel1l ube2g2 ubiquitin ubiquitous
Tagcloud (Difference) ?		abundance affects ancient associates conjugating connection cue dislocation droplet droplets endoplasmic engagement facilitates hrd1 impairs involves lipid localizes misfolded physically polyubiquitylation proteasome quality recruit reticulum sel1l ube2g2 ubiquitin ubiquitous
Tagcloud (Intersection) ?