PINX1 and MCRS1

Number of citations of the paper that reports this interaction (PMID 15044100)
6

Data Source:
BioGRID (pull down)
HPRD (in vivo, two hybrid, in vitro)

		PINX1	MCRS1
Gene Name		PIN2/TERF1 interacting, telomerase inhibitor 1	microspherule protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Kinetochore Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Spindle Intracellular Membrane-bounded Organelle	Histone Acetyltransferase Complex Nucleoplasm Nucleolus Cytoplasm Actin Cytoskeleton Cell Junction Ino80 Complex MLL1 Complex
	Molecular Function	Protein Binding Telomerase Inhibitor Activity Telomeric RNA Binding	Protein Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Telomere Maintenance Via Telomerase Mitotic Metaphase Plate Congression Negative Regulation Of Cell Proliferation Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity	DNA Repair DNA Recombination Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation
Pathways			Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS		Carotid intima media thickness ( 21909108) Retinal vascular caliber ( 21060863) Triglycerides ( 20686565)
Protein-Protein Interactions		10 interactors: AIDA CACYBP DHX15 GABPA MCRS1 MPZ PAFAH1B2 TERF1 TERT TP63	30 interactors: BLM CCDC53 CCDC85B CEP44 DAXX DVL2 FXR2 GCC1 GPBP1 IKZF1 KDM1A KIAA1958 KXD1 LIG4 LSM6 MAGEA11 MED4 NOP2 PBX2 PHC2 PINX1 PRMT5 RALYL SUV39H1 TERT TRIM37 UPF3B USHBP1 WBP11 ZBTB22
Entrez ID		54984	10445
HPRD ID		05934	11298
Ensembl ID		ENSG00000254093	ENSG00000187778
Uniprot IDs		Q96BK5	Q7Z372 Q96EZ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Replicative Cell Aging Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Cell Aging Aging Telomere Maintenance Via Telomerase RNA-dependent DNA Replication Chromatin Modification Telomere Maintenance Via Telomere Lengthening Chromatin Organization Ectoderm And Mesoderm Interaction Epidermal Cell Division Negative Regulation Of Production Of SiRNA Involved In RNA Interference Telomere Maintenance Chromosome Organization Negative Regulation Of RNA Interference Transcription, RNA-templated Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Negative Regulation Of Cellular Metabolic Process Regulation Of DNA Replication Telomeric Loop Formation Regulation Of Epidermal Cell Division Telomere Formation Via Telomerase Negative Regulation Of Mitotic Cell Cycle Phase Transition Female Genitalia Morphogenesis Negative Regulation Of Megakaryocyte Differentiation Cloacal Septation Urinary Bladder Development Mitotic Cell Cycle Checkpoint Developmental Process Regulation Of Metabolic Process Positive Regulation Of Fibroblast Apoptotic Process Cloaca Development Negative Regulation Of Telomere Maintenance Via Telomerase Prostatic Bud Formation Regulation Of Cell Death Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Mesoderm Development Telomere Assembly Positive Regulation Of Keratinocyte Proliferation Polarized Epithelial Cell Differentiation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Cell-cell Junction Maintenance Negative Regulation Of Cellular Senescence Lateral Sprouting From An Epithelium Regulation Of Cell Cycle Phase Transition	RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Chromosome Organization Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Gene Expression Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Chromatin Modification Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Chromatin Organization RRNA Processing RRNA Metabolic Process Positive Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Ribosome Biogenesis Telomere Maintenance Via Telomerase Telomere Maintenance Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated NcRNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process DNA Replication RNA-dependent DNA Replication RNA Processing Positive Regulation Of Transcription, DNA-templated Leukocyte Differentiation RNA Splicing DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Response To X-ray T Cell Differentiation Histone Modification
Tagcloud ?		9r becoming claimed cloning couple describes examples expresses g4s lowly lpts mbaf mbaff mcrs2 owing partners patents pin2 positional powerful seem successively suppressorlpts surveys tat telomerase trf1 trigger undefined	acetylates akhtar buscaino duncan gebhardt h4k16 hcf1 holz ino80 mendjan mof moz msl mueller myst myst1 nsl nucleosomal relaxed sas2 sas3 saumweber schelder stunnenberg taipale vermeulen wdr5 wilm ybf2
Tagcloud (Difference) ?		9r becoming claimed cloning couple describes examples expresses g4s lowly lpts mbaf mbaff mcrs2 owing partners patents pin2 positional powerful seem successively suppressorlpts surveys tat telomerase trf1 trigger undefined	acetylates akhtar buscaino duncan gebhardt h4k16 hcf1 holz ino80 mendjan mof moz msl mueller myst myst1 nsl nucleosomal relaxed sas2 sas3 saumweber schelder stunnenberg taipale vermeulen wdr5 wilm ybf2
Tagcloud (Intersection) ?