PINX1 and GABPA

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PINX1	GABPA
Gene Name		PIN2/TERF1 interacting, telomerase inhibitor 1	GA binding protein transcription factor, alpha subunit 60kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Kinetochore Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Spindle Intracellular Membrane-bounded Organelle	Nuclear Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding Telomerase Inhibitor Activity Telomeric RNA Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Telomere Maintenance Via Telomerase Mitotic Metaphase Plate Congression Negative Regulation Of Cell Proliferation Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Transcription From RNA Polymerase II Promoter Organelle Organization Mitochondrion Organization Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			Organelle biogenesis and maintenance Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs
Diseases
GWAS		Carotid intima media thickness ( 21909108) Retinal vascular caliber ( 21060863) Triglycerides ( 20686565)
Protein-Protein Interactions		10 interactors: AIDA CACYBP DHX15 GABPA MCRS1 MPZ PAFAH1B2 TERF1 TERT TP63	10 interactors: APP ATF1 CREBBP EP300 GABPB1 HCFC1 MED1 PINX1 SP1 SP3
Entrez ID		54984	2551
HPRD ID		05934	11793
Ensembl ID		ENSG00000254093	ENSG00000154727
Uniprot IDs		Q96BK5	A8IE48 Q06546 Q8IYS3
PDB IDs
Enriched GO Terms of Interacting Partners?		Replicative Cell Aging Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Cell Aging Aging Telomere Maintenance Via Telomerase RNA-dependent DNA Replication Chromatin Modification Telomere Maintenance Via Telomere Lengthening Chromatin Organization Ectoderm And Mesoderm Interaction Epidermal Cell Division Negative Regulation Of Production Of SiRNA Involved In RNA Interference Telomere Maintenance Chromosome Organization Negative Regulation Of RNA Interference Transcription, RNA-templated Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Negative Regulation Of Cellular Metabolic Process Regulation Of DNA Replication Telomeric Loop Formation Regulation Of Epidermal Cell Division Telomere Formation Via Telomerase Negative Regulation Of Mitotic Cell Cycle Phase Transition Female Genitalia Morphogenesis Negative Regulation Of Megakaryocyte Differentiation Cloacal Septation Urinary Bladder Development Mitotic Cell Cycle Checkpoint Developmental Process Regulation Of Metabolic Process Positive Regulation Of Fibroblast Apoptotic Process Cloaca Development Negative Regulation Of Telomere Maintenance Via Telomerase Prostatic Bud Formation Regulation Of Cell Death Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Mesoderm Development Telomere Assembly Positive Regulation Of Keratinocyte Proliferation Polarized Epithelial Cell Differentiation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Cell-cell Junction Maintenance Negative Regulation Of Cellular Senescence Lateral Sprouting From An Epithelium Regulation Of Cell Cycle Phase Transition	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Enucleate Erythrocyte Differentiation Positive Regulation Of Cellular Metabolic Process Megakaryocyte Differentiation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Immune System Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Homeostatic Process Positive Regulation By Host Of Viral Transcription Embryonic Process Involved In Female Pregnancy Negative Regulation Of Transcription From RNA Polymerase II Promoter N-terminal Protein Amino Acid Acetylation Regulation Of Metabolic Process Erythrocyte Differentiation Histone Acetylation Erythrocyte Homeostasis Embryonic Placenta Development Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Myeloid Cell Homeostasis Monocyte Differentiation Notch Signaling Pathway
Tagcloud ?		9r becoming claimed cloning couple describes examples expresses g4s lowly lpts mbaf mbaff mcrs2 owing partners patents pin2 positional powerful seem successively suppressorlpts surveys tat telomerase trf1 trigger undefined	annotation assigned bindings cistrome consensus enriched examines expresses foxa2 generates hepatic hre implying isoforms livers motifs principle ra rar rara raralpha rarb rarbeta redundant responsiveness sp1 stores tca uncovered
Tagcloud (Difference) ?		9r becoming claimed cloning couple describes examples g4s lowly lpts mbaf mbaff mcrs2 owing partners patents pin2 positional powerful seem successively suppressorlpts surveys tat telomerase trf1 trigger undefined	annotation assigned bindings cistrome consensus enriched examines foxa2 generates hepatic hre implying isoforms livers motifs principle ra rar rara raralpha rarb rarbeta redundant responsiveness sp1 stores tca uncovered
Tagcloud (Intersection) ?		expresses