PINX1 and MPZ

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PINX1	MPZ
Gene Name		PIN2/TERF1 interacting, telomerase inhibitor 1	myelin protein zero
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Kinetochore Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Spindle Intracellular Membrane-bounded Organelle	Plasma Membrane Integral Component Of Plasma Membrane Myelin Sheath
	Molecular Function	Protein Binding Telomerase Inhibitor Activity Telomeric RNA Binding	Structural Molecule Activity
	Biological Process	Telomere Maintenance Via Telomerase Mitotic Metaphase Plate Congression Negative Regulation Of Cell Proliferation Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity	Synaptic Transmission Cell-cell Junction Maintenance
Pathways
Drugs
Diseases
GWAS		Carotid intima media thickness ( 21909108) Retinal vascular caliber ( 21060863) Triglycerides ( 20686565)	Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		10 interactors: AIDA CACYBP DHX15 GABPA MCRS1 MPZ PAFAH1B2 TERF1 TERT TP63	3 interactors: PINX1 PMP22 PSMB3
Entrez ID		54984	4359
HPRD ID		05934	01159
Ensembl ID		ENSG00000254093	ENSG00000158887
Uniprot IDs		Q96BK5	P25189
PDB IDs			1N2P 3OAI
Enriched GO Terms of Interacting Partners?		Replicative Cell Aging Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Cell Aging Aging Telomere Maintenance Via Telomerase RNA-dependent DNA Replication Chromatin Modification Telomere Maintenance Via Telomere Lengthening Chromatin Organization Ectoderm And Mesoderm Interaction Epidermal Cell Division Negative Regulation Of Production Of SiRNA Involved In RNA Interference Telomere Maintenance Chromosome Organization Negative Regulation Of RNA Interference Transcription, RNA-templated Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Negative Regulation Of Cellular Metabolic Process Regulation Of DNA Replication Telomeric Loop Formation Regulation Of Epidermal Cell Division Telomere Formation Via Telomerase Negative Regulation Of Mitotic Cell Cycle Phase Transition Female Genitalia Morphogenesis Negative Regulation Of Megakaryocyte Differentiation Cloacal Septation Urinary Bladder Development Mitotic Cell Cycle Checkpoint Developmental Process Regulation Of Metabolic Process Positive Regulation Of Fibroblast Apoptotic Process Cloaca Development Negative Regulation Of Telomere Maintenance Via Telomerase Prostatic Bud Formation Regulation Of Cell Death Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Mesoderm Development Telomere Assembly Positive Regulation Of Keratinocyte Proliferation Polarized Epithelial Cell Differentiation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Cell-cell Junction Maintenance Negative Regulation Of Cellular Senescence Lateral Sprouting From An Epithelium Regulation Of Cell Cycle Phase Transition	Negative Regulation Of Transferase Activity Bleb Assembly Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Negative Regulation Of Cell Proliferation Mitotic Cell Cycle Process RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Mitotic Metaphase Plate Congression Telomere Maintenance Via Telomere Lengthening Myelin Assembly Metaphase Plate Congression Establishment Of Chromosome Localization Cell Cycle Process Cell Death Death Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Cell Cycle Positive Regulation Of Ligase Activity Telomere Maintenance Mitotic Sister Chromatid Segregation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Sister Chromatid Segregation Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Proliferation Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint
Tagcloud ?		9r becoming claimed cloning couple describes examples expresses g4s lowly lpts mbaf mbaff mcrs2 owing partners patents pin2 positional powerful seem successively suppressorlpts surveys tat telomerase trf1 trigger undefined	1p35 1q 3q 7p axonal charcot cmt cmt1b cmt2 cmt2a cmt2b cmt2d dejerine demyelinating genetically hereditary hmsn hypomyelination inherited marie missense myelin neuropathies neuropathy sardinian ser44phe sottas tooth zero
Tagcloud (Difference) ?		9r becoming claimed cloning couple describes examples expresses g4s lowly lpts mbaf mbaff mcrs2 owing partners patents pin2 positional powerful seem successively suppressorlpts surveys tat telomerase trf1 trigger undefined	1p35 1q 3q 7p axonal charcot cmt cmt1b cmt2 cmt2a cmt2b cmt2d dejerine demyelinating genetically hereditary hmsn hypomyelination inherited marie missense myelin neuropathies neuropathy sardinian ser44phe sottas tooth zero
Tagcloud (Intersection) ?