PINX1 and PAFAH1B2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PINX1	PAFAH1B2
Description		PIN2 (TERF1) interacting telomerase inhibitor 1	platelet activating factor acetylhydrolase 1b catalytic subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Mitochondrion Spindle	Fibrillar Center Extracellular Region Nucleolus Cytoplasm Cytosol Plasma Membrane 1-alkyl-2-acetylglycerophosphocholine Esterase Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleic Acid Binding Protein Binding Telomerase Inhibitor Activity Protein-containing Complex Binding Telomerase RNA Binding	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Protein Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity Platelet-activating Factor Acetyltransferase Activity
	Biological Process	Telomere Maintenance Via Telomerase Mitotic Metaphase Chromosome Alignment Negative Regulation Of Cell Population Proliferation Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Protein Localization To Nucleolus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Protein Localization To Nucleolus	Lipid Metabolic Process Spermatogenesis Lipid Catabolic Process Positive Regulation Of Macroautophagy
Pathways			Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adventurousness ( 30643258) Anxiety/tension (special factor of neuroticism) ( 30867560) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder ( 30804558) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness ( 30510157 21909108) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Gut microbiota (beta diversity) ( 27723756) Lymphocyte count ( 27863252 32888494) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (calcium channel blockers) ( 31015401) Retinal vascular caliber ( 21060863) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 26316170) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 28334899 32154731) Triglycerides ( 30275531 24097068 20686565) Type 2 diabetes ( 30054458) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 27863252 32888494)	Adult body size ( 32376654) Blood protein levels ( 23696881) HDL cholesterol ( 24507774) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Protein quantitative trait loci ( 18464913) Refractive error ( 32231278) Systolic blood pressure ( 30578418)
Interacting Genes		17 interacting genes: AIDA APP C14orf119 CACYBP EIF1AD GABPA GYS1 MCRS1 MPZ PAFAH1B2 TERF1 TERT TFRC TLK1 TNPO2 TP63 UBL5	19 interacting genes: ACIN1 ASF1A CCT3 CLVS2 CRK PAFAH1B1 PAFAH1B3 PINX1 PPP1R12C PRKN REXO1 RPLP0 SLA SNUPN STAT3 TIMM50 TRIM55 TRIM63 ZFP36L1
Entrez ID		54984	5049
HPRD ID		05934	03940
Ensembl ID		ENSG00000254093	ENSG00000168092
Uniprot IDs		Q96BK5	P68402 V9HW44
PDB IDs			1VYH
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Localization Regulation Of Protein Localization To Nucleus Nuclear Envelope Lumen Nuclear Telomere Cap Complex Telomerase Activity Regulation Of Protein Localization To Nucleolus Positive Regulation Of Protein Localization To Nucleolus Response To Manganese Ion Protein-folding Chaperone Binding Protein Homodimerization Activity Telomere Maintenance Positive Regulation Of Protein Localization To Nucleus Cellular Response To Leukemia Inhibitory Factor Response To Leukemia Inhibitory Factor Notch Signaling Pathway RNA-templated DNA Biosynthetic Process Positive Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Regulation Of DNA Replication Negative Regulation Of Cellular Senescence Telomeric DNA Binding Telomere Organization Amyloid-beta Complex Growth Cone Lamellipodium Response To Copper Ion Response To Metal Ion Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Establishment Of Protein Localization To Telomere Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Telomere Maintenance Via Telomere Lengthening TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Ectoderm And Mesoderm Interaction Epidermal Cell Division Determination Of Ventral Identity Positive Regulation Of Stem Cell Proliferation Regulation Of Cellular Senescence Acetylcholine Receptor Activator Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import	1-alkyl-2-acetylglycerophosphocholine Esterase Complex Positive Regulation Of Monocyte Differentiation Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Diapedesis Reelin-mediated Signaling Pathway Protein Localization To Organelle Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Monocyte Differentiation Regulation Of ATP Biosynthetic Process Negative Regulation Of Glycolytic Process Positive Regulation Of Myeloid Cell Differentiation Phospholipase Binding Negative Regulation Of ATP Metabolic Process Response To Glucocorticoid Intracellular Protein Localization Response To Hormone Microtubule Nucleus Regulation Of JNK Cascade Protein-containing Complex Binding Response To Corticosteroid Negative Regulation Of JNK Cascade Positive Regulation Of Cell Growth Positive Regulation Of ATP Metabolic Process Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Protein Localization To Mitochondrion Regulation Of Reactive Oxygen Species Biosynthetic Process RNA Binding Cell Population Proliferation Organelle Organization Negative Regulation Of Spontaneous Neurotransmitter Secretion Protein Localization To Nucleus Regulation Of Telomere Maintenance Via Telomerase Phosphotyrosine Residue Binding Regulation Of Myeloid Cell Differentiation Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay Cellular Response To Raffinose Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Erythrocyte Differentiation Response To Steroid Hormone Helper T Cell Diapedesis Leukocyte Migration Positive Regulation Of Protein Localization Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin
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