PINX1 and TERT

Number of citations of the paper that reports this interaction (PMID 11701125)
53

Data Source:
HPRD (in vivo, in vitro)

		PINX1	TERT
Gene Name		PIN2/TERF1 interacting, telomerase inhibitor 1	telomerase reverse transcriptase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Kinetochore Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Spindle Intracellular Membrane-bounded Organelle	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Telomerase Holoenzyme Complex Nucleolus PML Body RNA-directed RNA Polymerase Complex Mitochondrial Nucleoid TERT-RMRP Complex
	Molecular Function	Protein Binding Telomerase Inhibitor Activity Telomeric RNA Binding	TRNA Binding Transcription Coactivator Binding DNA Binding Telomerase Activity Telomeric Template RNA Reverse Transcriptase Activity RNA-directed RNA Polymerase Activity Protein Binding Nucleotidyltransferase Activity Telomeric DNA Binding Protein Homodimerization Activity Metal Ion Binding Telomeric RNA Binding
	Biological Process	Telomere Maintenance Via Telomerase Mitotic Metaphase Plate Congression Negative Regulation Of Cell Proliferation Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity	Telomere Maintenance Transcription, RNA-templated Age-dependent Telomere Shortening Telomere Maintenance Via Telomerase Mitochondrion Organization DNA Strand Elongation Positive Regulation Of Wnt Signaling Pathway Production Of SiRNA Involved In RNA Interference Telomere Formation Via Telomerase Replicative Senescence Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Telomere Maintenance Chromosome Maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex Extension of Telomeres Telomere Extension By Telomerase XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Carotid intima media thickness ( 21909108) Retinal vascular caliber ( 21060863) Triglycerides ( 20686565)	Bladder cancer ( 20972438) Breast cancer ( 22037553 23535729 23535733) Glioma ( 21827660 21531791 22886559 19578367) Idiopathic pulmonary fibrosis ( 18835860) Interstitial lung disease ( 23583980) Lung adenocarcinoma ( 20700438 19836008 22797724 20871597) Lung cancer ( 21725308 23143601 18978790) Melanoma ( 21983787) Prostate cancer ( 21743467) Prostate-specific antigen levels ( 21160077) Red blood cell count ( 20139978) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240)
Protein-Protein Interactions		10 interactors: AIDA CACYBP DHX15 GABPA MCRS1 MPZ PAFAH1B2 TERF1 TERT TP63	51 interactors: ABL1 ACAA2 AKT1 ANXA2 ATP5B C19orf40 CCT5 CIB1 DDX51 DYNLL1 DYRK2 EIF2S1 ENO1 GLA HSP90AA1 HSPA4 IREB2 MCRS1 MDM2 MTOR NCL PABPC1 PBK PFDN1 PHF20L1 PINX1 PPIA PRKCA PTGES3 RELA RPS6KB1 RUVBL1 RUVBL2 SERBP1 SLC7A11 SMG5 SMG6 SRC STEAP4 TEP1 TERF1 TGFBR2 TIMM21 TPP1 TUBA1B U2SURP XPO1 XRCC5 XRCC6 YWHAQ YWHAZ
Entrez ID		54984	7015
HPRD ID		05934	01754
Ensembl ID		ENSG00000254093	ENSG00000164362
Uniprot IDs		Q96BK5	O14746
PDB IDs			2BCK 4B18
Enriched GO Terms of Interacting Partners?		Replicative Cell Aging Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Cell Aging Aging Telomere Maintenance Via Telomerase RNA-dependent DNA Replication Chromatin Modification Telomere Maintenance Via Telomere Lengthening Chromatin Organization Ectoderm And Mesoderm Interaction Epidermal Cell Division Negative Regulation Of Production Of SiRNA Involved In RNA Interference Telomere Maintenance Chromosome Organization Negative Regulation Of RNA Interference Transcription, RNA-templated Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Negative Regulation Of Cellular Metabolic Process Regulation Of DNA Replication Telomeric Loop Formation Regulation Of Epidermal Cell Division Telomere Formation Via Telomerase Negative Regulation Of Mitotic Cell Cycle Phase Transition Female Genitalia Morphogenesis Negative Regulation Of Megakaryocyte Differentiation Cloacal Septation Urinary Bladder Development Mitotic Cell Cycle Checkpoint Developmental Process Regulation Of Metabolic Process Positive Regulation Of Fibroblast Apoptotic Process Cloaca Development Negative Regulation Of Telomere Maintenance Via Telomerase Prostatic Bud Formation Regulation Of Cell Death Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Mesoderm Development Telomere Assembly Positive Regulation Of Keratinocyte Proliferation Polarized Epithelial Cell Differentiation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Cell-cell Junction Maintenance Negative Regulation Of Cellular Senescence Lateral Sprouting From An Epithelium Regulation Of Cell Cycle Phase Transition	Organelle Organization Telomere Maintenance Cellular Response To Stress Response To Stress Response To Abiotic Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Intracellular Transport DNA Metabolic Process Mitotic Cell Cycle Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization RNA-dependent DNA Replication Regulation Of Cellular Localization Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Regulation Of Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Drug Regulation Of Protein Localization Regulation Of Cell Death Apoptotic Process Cell Cycle Response To Organic Substance Positive Regulation Of Organelle Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stimulus Mitotic Cell Cycle Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Peptidyl-amino Acid Modification Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Hypoxia ERBB Signaling Pathway Cellular Response To Decreased Oxygen Levels Negative Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Homeostatic Process Fc Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Oxygen Levels Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		9r becoming claimed cloning couple describes examples expresses g4s lowly lpts mbaf mbaff mcrs2 owing partners patents pin2 positional powerful seem successively suppressorlpts surveys tat telomerase trf1 trigger undefined	5alpha butyl chlorinated cholestane coprostanol dihydrocholesterol epicoprostanol ether experiment extraction fid final gc internal involves limit liquid methanol method microg namely quantification recovery reextraction saponification silylation solvents sterols urine
Tagcloud (Difference) ?		9r becoming claimed cloning couple describes examples expresses g4s lowly lpts mbaf mbaff mcrs2 owing partners patents pin2 positional powerful seem successively suppressorlpts surveys tat telomerase trf1 trigger undefined	5alpha butyl chlorinated cholestane coprostanol dihydrocholesterol epicoprostanol ether experiment extraction fid final gc internal involves limit liquid methanol method microg namely quantification recovery reextraction saponification silylation solvents sterols urine
Tagcloud (Intersection) ?