DUSP23 and SMPD1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		DUSP23	SMPD1
Gene Name		dual specificity phosphatase 23	sphingomyelin phosphodiesterase 1, acid lysosomal
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Extracellular Vesicular Exosome	Extracellular Space Lysosome Endosome Plasma Membrane Lamellar Body Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity	Sphingomyelin Phosphodiesterase Activity Protein Binding Hydrolase Activity, Acting On Glycosyl Bonds
	Biological Process	Peptidyl-tyrosine Dephosphorylation	Sphingolipid Metabolic Process Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Signal Transduction Nervous System Development Termination Of Signal Transduction Positive Regulation Of Protein Dephosphorylation Response To Cocaine Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Small Molecule Metabolic Process Ceramide Biosynthetic Process
Pathways			Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism
Drugs			Desipramine
Diseases
GWAS		C-reactive protein ( 22939635) Interstitial lung disease ( 21787189)
Protein-Protein Interactions		24 interactors: ASB13 CCDC186 DBI DBN1 DNMT3B EDRF1 EED EXOSC8 GCM1 KAT5 KBTBD7 KIAA1377 MKRN1 MRPL20 MTFR1 NIF3L1 PRDX4 RPL8 RUFY2 SHC1 SMPD1 TMOD3 TUBA1A ZNF746	6 interactors: ANXA4 ANXA7 ASAH1 DUSP23 NGFRAP1 NR1H2
Entrez ID		54935	6609
HPRD ID		07908	06353
Ensembl ID		ENSG00000158716	ENSG00000166311
Uniprot IDs		Q9BVJ7	G3XAB5 P17405 Q59EN6
PDB IDs		2IMG 4ERC
Enriched GO Terms of Interacting Partners?		Cellular Metabolic Process Organelle Organization Regulation Of Gene Expression By Genetic Imprinting Gene Expression Genetic Imprinting Positive Regulation Of Histone Methylation Negative Regulation Of Male Germ Cell Proliferation Regulation Of Histone Methylation Positive Regulation Of Protein Modification Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Positive Regulation Of Histone Modification Negative Regulation Of Gene Expression, Epigenetic Cellular Nitrogen Compound Metabolic Process Regulation Of Male Germ Cell Proliferation Dihydrobiopterin Metabolic Process Cell Communication By Chemical Coupling S-adenosylmethioninamine Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization	Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion Positive Regulation Of High-density Lipoprotein Particle Assembly Regulation Of High-density Lipoprotein Particle Assembly Negative Regulation Of Interleukin-8 Secretion Negative Regulation Of Pinocytosis Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Response To Organic Substance Negative Regulation Of Cholesterol Storage Positive Regulation Of Digestive System Process Cellular Water Homeostasis Negative Regulation Of Interleukin-8 Production Positive Regulation Of Lipoprotein Lipase Activity Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Interleukin-8 Secretion Regulation Of Cholesterol Homeostasis Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Efflux Regulation Of Protein Secretion Negative Regulation Of Transport Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Transport Negative Regulation Of Lipid Storage Regulation Of Triglyceride Biosynthetic Process Regulation Of Cholesterol Efflux Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of Lipid Transport Retinoic Acid Receptor Signaling Pathway Epithelial Cell Differentiation Positive Regulation Of Lipid Storage Cell Volume Homeostasis Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Triglyceride Metabolic Process Regulation Of Cholesterol Transport Negative Regulation Of Cytokine Secretion Response To Salt Stress Regulation Of Protein Transport Negative Regulation Of Innate Immune Response Negative Regulation Of Cytokine-mediated Signaling Pathway
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