DUSP23 and GCM1

Number of citations of the paper that reports this interaction (PubMedID 20855292)
31

Data Source:
BioGRID (enzymatic study)

		DUSP23	GCM1
Description		dual specificity phosphatase 23	glial cells missing transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Dephosphorylation Cilium Assembly	Syncytium Formation By Plasma Membrane Fusion Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Gliogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Fate Commitment Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Branching Involved In Labyrinthine Layer Morphogenesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development
Pathways
Drugs		4-Nitrophenyl Phosphate
Diseases
GWAS		Bone mineral density (Ward's triangle area) ( 27397699) C-reactive protein ( 22939635) Interstitial lung disease ( 21787189)	Cerebrospinal fluid AB1-42 levels ( 26252872)
Interacting Genes		32 interacting genes: ASB13 ASB6 BANF2 CCDC186 CEP126 DBI DBN1 DDIT4L DNMT3B EDRF1 EED EXOSC8 GCM1 KAT5 KBTBD7 MKRN1 MRNIP MRPL20 MTFR1 NIF3L1 PRDX4 PSMB8 PSME2 RPL8 RUFY2 SHC1 SMPD1 TCF4 TMOD3 TUBA1A UBA3 ZNF746	9 interacting genes: CAMK1 CREBBP DUSP23 HDAC1 HDAC3 HDAC4 HDAC5 SENP1 UBE2I
Entrez ID		54935	8521
HPRD ID		07908	04757
Ensembl ID		ENSG00000158716	ENSG00000137270
Uniprot IDs		A0A140VJI5 Q9BVJ7	Q9NP62
PDB IDs		2IMG 4ERC
Enriched GO Terms of Interacting Partners?			Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Negative Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Complex Regulation Of Myotube Differentiation Regulation Of Muscle Cell Differentiation DNA-binding Transcription Factor Binding Protein Deacetylation Negative Regulation Of Muscle Cell Differentiation Regulation Of Striated Muscle Cell Differentiation Macromolecule Deacylation Histone Deacetylase Binding Protein Lysine Delactylase Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression, Epigenetic Protein Decrotonylase Activity Histone Decrotonylase Activity Transcription Corepressor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Sumoylation Negative Regulation Of Transcription By RNA Polymerase II Protein Modification Process Regulation Of Transcription By RNA Polymerase II Transcription Repressor Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Chromatin Remodeling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Organization SUMO Transferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation DNA-binding Transcription Activator Activity Hydrolase Activity Chromatin Binding Presynaptic Cytosol Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process
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