DUSP23 and UBA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DUSP23	UBA3
Description		dual specificity phosphatase 23	ubiquitin like modifier activating enzyme 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Hydrolase Activity Phosphatase Activity	Nucleotide Binding Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity NEDD8 Activating Enzyme Activity NEDD8 Transferase Activity Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Dephosphorylation Cilium Assembly	Mitotic Cell Cycle Proteolysis Endomitotic Cell Cycle Protein Modification Process Post-translational Protein Modification Protein Neddylation Regulation Of Cell Cycle
Pathways			Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		4-Nitrophenyl Phosphate
Diseases
GWAS		Bone mineral density (Ward's triangle area) ( 27397699) C-reactive protein ( 22939635) Interstitial lung disease ( 21787189)	Meat-related diet ( 32066663)
Interacting Genes		32 interacting genes: ASB13 ASB6 BANF2 CCDC186 CEP126 DBI DBN1 DDIT4L DNMT3B EDRF1 EED EXOSC8 GCM1 KAT5 KBTBD7 MKRN1 MRNIP MRPL20 MTFR1 NIF3L1 PRDX4 PSMB8 PSME2 RPL8 RUFY2 SHC1 SMPD1 TCF4 TMOD3 TUBA1A UBA3 ZNF746	16 interacting genes: CHD3 CPNE2 CUL5 DSCAM DUSP23 IMPA2 KDM1A NAE1 NEDD8 OGT RNF7 TRIM55 TRIM63 UBE2D2 UBE2F UBE2M
Entrez ID		54935	9039
HPRD ID		07908	04413
Ensembl ID		ENSG00000158716	ENSG00000144744
Uniprot IDs		A0A140VJI5 Q9BVJ7	F8W8D4 Q8TBC4
PDB IDs		2IMG 4ERC	1R4M 1R4N 1TT5 1Y8X 1YOV 2LQ7 2NVU 3DBH 3DBL 3DBR 3FN1 3GZN 5JJM
Enriched GO Terms of Interacting Partners?			Protein Neddylation Protein Modification By Small Protein Conjugation NEDD8 Transferase Activity Protein Modification Process Post-translational Protein Modification Regulation Of Cell Junction Assembly NEDD8 Conjugating Enzyme Activity Negative Regulation Of Focal Adhesion Disassembly NEDD8 Ligase Activity Protein Metabolic Process Regulation Of Postsynapse Assembly Protein Ubiquitination Regulation Of Synapse Assembly Erythropoietin-mediated Signaling Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Reelin-mediated Signaling Pathway Epithelial To Mesenchymal Transition Ubiquitin-protein Transferase Activity Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul5-RING Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein Polyubiquitination Layer Formation In Cerebral Cortex Mesenchymal Cell Differentiation Negative Regulation Of Focal Adhesion Assembly Regulation Of Synapse Organization Innate Immune Response Growth Hormone Receptor Signaling Pathway Ubiquitin Protein Ligase Activity Regulation Of Postsynapse Organization Proteolysis Involved In Protein Catabolic Process CGAS/STING Signaling Pathway Positive Regulation Of Focal Adhesion Assembly Nucleus Defense Response To Symbiont Proteolysis Transferase Activity Defense Response To Other Organism Negative Regulation Of Cell-matrix Adhesion Protein K11-linked Ubiquitination Regulation Of Cellular Component Organization Macromolecule Metabolic Process Regulation Of Neuron Migration Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Defense Response Regulation Of Glycolytic Process
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