RASIP1 and RRAS2

Number of citations of the paper that reports this interaction (PMID 15031288)
17

Data Source:
HPRD (two hybrid)

		RASIP1	RRAS2
Gene Name		Ras interacting protein 1	related RAS viral (r-ras) oncogene homolog 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Stack Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Vesicular Exosome
	Molecular Function		GTPase Activity Protein Binding GTP Binding
	Biological Process	Angiogenesis Vasculogenesis Signal Transduction Negative Regulation Of Autophagy Regulation Of Rho GTPase Activity Branching Morphogenesis Of An Epithelial Tube	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Crohn's disease ( 21102463) Dietary macronutrient intake ( 23372041) Retinal vascular caliber ( 21060863)	Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		8 interactors: ARFGAP1 HRAS LDB2 MRAS RAP1A RAP2A RRAS RRAS2	29 interactors: ACVR1 AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB LGALS4 MLLT4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6
Entrez ID		54922	22800
HPRD ID		15214	02518
Ensembl ID		ENSG00000105538	ENSG00000133818
Uniprot IDs		Q5U651 Q7L251 Q8IUR2	B7Z5Z2 P62070
PDB IDs			2ERY
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Rap Protein Signal Transduction Intracellular Signal Transduction Regulation Of Cell Migration Regulation Of Phosphorylation Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Movement Positive Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Signal Transduction Cell Differentiation Activation Of MAPKK Activity Developmental Process Regulation Of Protein Phosphorylation Signaling Positive Regulation Of Cellular Protein Metabolic Process Cell Communication Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Projection Organization Positive Regulation Of Kinase Activity Regulation Of Ras GTPase Activity System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Cellular Response To Stimulus Positive Regulation Of ERK1 And ERK2 Cascade Actin Cytoskeleton Organization Regulation Of Signal Transduction Actin Filament-based Process Generation Of Neurons Regulation Of Ras Protein Signal Transduction Regulation Of Cell Differentiation Multicellular Organismal Development Neurogenesis Regulation Of JNK Cascade Positive Regulation Of GTPase Activity Anatomical Structure Development Regulation Of Signaling Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Regulation Of Stress-activated MAPK Cascade	Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Metabolic Process Signal Transduction Response To Stimulus Signaling Cell Communication Positive Regulation Of Metabolic Process Cellular Response To Stimulus Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Catalytic Activity Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Hydrolase Activity Cellular Response To Growth Factor Stimulus Regulation Of Protein Phosphorylation Response To Growth Factor Regulation Of Intracellular Signal Transduction Endothelial Cell Differentiation Positive Regulation Of Catalytic Activity Regulation Of Cell Death Endothelium Development Regulation Of Cellular Protein Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cellular Process Regulation Of GTPase Activity Response To Stress Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Signaling Regulation Of Ras Protein Signal Transduction Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Negative Regulation Of Cell Death Positive Regulation Of Rap GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Bone Mineralization Defense Response BMP Signaling Pathway Regulation Of Cytokine Production Regulation Of Ras GTPase Activity Regulation Of Protein Localization
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