RASIP1

Description		Ras interacting protein 1
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Golgi Stack Cell-cell Junction Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Homodimerization Activity GTPase Binding
	Biological Process	Angiogenesis Vasculogenesis Signal Transduction Negative Regulation Of Autophagy Positive Regulation Of Integrin Activation Negative Regulation Of Rho Protein Signal Transduction Regulation Of GTPase Activity Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Membrane Permeability Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity
Pathways
Drugs
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Bipolar disorder ( 21926972) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cooked vegetable consumption ( 32066663) Crohn's disease ( 21102463 28067908) Dietary macronutrient intake ( 23372041) Estimated glomerular filtration rate ( 31015462) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean platelet volume ( 27863252 32888494) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Platelet count ( 32888494) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Retinal vascular caliber ( 21060863) Urinary albumin-to-creatinine ratio ( 31511532) Vitamin B levels in ischemic stroke ( 25147783) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		9 interacting genes: ARFGAP1 HRAS LDB2 MRAS RAP1A RAP2A RRAS RRAS2 UBC
Entrez ID		54922
HPRD ID		15214
Ensembl ID		ENSG00000105538
Uniprot IDs		Q5U651 Q7L251 Q8IUR2
PDB IDs		5KHO 5KHQ
Enriched GO Terms of Interacting Partners?		GDP Binding Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding G Protein Activity Ras Protein Signal Transduction Schwann Cell Migration Intracellular Signaling Cassette Rap Protein Signal Transduction Positive Regulation Of Vasculogenesis Regulation Of Vasculogenesis Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Hydrolase Activity Regulation Of Glial Cell Migration Regulation Of Cell Migration Nucleotide Binding Regulation Of Cell Motility Intracellular Signal Transduction Regulation Of Protein Localization To Synapse Regulation Of Locomotion Regulation Of Receptor Localization To Synapse Glial Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Plasma Membrane Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Projection Organization GTPase Complex Response To Antineoplastic Agent Phospholipase C Activator Activity Negative Regulation Of Schwann Cell Migration Positive Regulation Of Schwann Cell Migration Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Component Biogenesis Regulation Of JNK Cascade Positive Regulation Of Microvillus Assembly Regulation Of Protein Localization To Cell Periphery Oncogene-induced Cell Senescence Golgi Membrane Regulation Of Protein Localization To Membrane Golgi Apparatus Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Synaptic Vesicle Exocytosis Guanyl-nucleotide Exchange Factor Complex Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Negative Regulation Of Glial Cell Migration LIM Domain Binding
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