RASIP1 and MRAS

Number of citations of the paper that reports this interaction (PubMedID 15031288)
0

Data Source:
HPRD (in vitro)

		RASIP1	MRAS
Description		Ras interacting protein 1	muscle RAS oncogene homolog
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Golgi Stack Cell-cell Junction Protein-containing Complex Perinuclear Region Of Cytoplasm	Protein Phosphatase Type 1 Complex Plasma Membrane Membrane
	Molecular Function	Protein Binding Protein Homodimerization Activity GTPase Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding GTP-dependent Protein Binding
	Biological Process	Angiogenesis Vasculogenesis Signal Transduction Negative Regulation Of Autophagy Positive Regulation Of Integrin Activation Negative Regulation Of Rho Protein Signal Transduction Regulation Of GTPase Activity Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Membrane Permeability Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity	Signal Transduction Ras Protein Signal Transduction Actin Cytoskeleton Organization Cellular Response To Leukemia Inhibitory Factor
Pathways			RAF activation SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling
Drugs
Diseases
GWAS		Alcohol consumption ( 31358974) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Bipolar disorder ( 21926972) Blood protein levels in cardiovascular risk ( 28369058) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cooked vegetable consumption ( 32066663) Crohn's disease ( 21102463 28067908) Dietary macronutrient intake ( 23372041) Estimated glomerular filtration rate ( 31015462) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Inflammatory bowel disease ( 28067908) Inflammatory skin disease ( 25574825) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean platelet volume ( 27863252 32888494) Meat-related diet ( 32066663) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Platelet count ( 32888494) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Retinal vascular caliber ( 21060863) Urinary albumin-to-creatinine ratio ( 31511532) Vitamin B levels in ischemic stroke ( 25147783) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	A body shape index ( 34021172) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Chronotype ( 30696823) Coronary artery disease ( 24262325 33020668 32469254 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990 19198612) Daytime nap ( 33568662) Diastolic blood pressure ( 27841878) Essential hypertension (time to event) ( 32589924) Myocardial infarction ( 33532862) Systolic blood pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: ARFGAP1 HRAS LDB2 MRAS RAP1A RAP2A RRAS RRAS2 UBC	11 interacting genes: AFDN BRAF ELOC PIK3CA RAF1 RALGDS RAPGEF5 RAPGEF6 RASIP1 RASSF5 RHOU
Entrez ID		54922	22808
HPRD ID		15214	06662
Ensembl ID		ENSG00000105538	ENSG00000158186
Uniprot IDs		Q5U651 Q7L251 Q8IUR2	O14807 Q6FGP0 Q8WVM9
PDB IDs		5KHO 5KHQ	7SD0 7TVF 7TXH 7UPI 9B4R 9B4T 9C1A 9C1B
Enriched GO Terms of Interacting Partners?		GDP Binding Small GTPase-mediated Signal Transduction GTPase Activity GTP Binding G Protein Activity Ras Protein Signal Transduction Schwann Cell Migration Intracellular Signaling Cassette Rap Protein Signal Transduction Positive Regulation Of Vasculogenesis Regulation Of Vasculogenesis Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Hydrolase Activity Regulation Of Glial Cell Migration Regulation Of Cell Migration Nucleotide Binding Regulation Of Cell Motility Intracellular Signal Transduction Regulation Of Protein Localization To Synapse Regulation Of Locomotion Regulation Of Receptor Localization To Synapse Glial Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Plasma Membrane Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Projection Organization GTPase Complex Response To Antineoplastic Agent Phospholipase C Activator Activity Negative Regulation Of Schwann Cell Migration Positive Regulation Of Schwann Cell Migration Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Component Biogenesis Regulation Of JNK Cascade Positive Regulation Of Microvillus Assembly Regulation Of Protein Localization To Cell Periphery Oncogene-induced Cell Senescence Golgi Membrane Regulation Of Protein Localization To Membrane Golgi Apparatus Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Synaptic Vesicle Exocytosis Guanyl-nucleotide Exchange Factor Complex Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Negative Regulation Of Glial Cell Migration LIM Domain Binding	Intracellular Signaling Cassette Signal Transduction Guanyl-nucleotide Exchange Factor Activity ERBB Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Small GTPase Binding Intracellular Signal Transduction Establishment Of Endothelial Intestinal Barrier Face Development Positive Regulation Of Peptidyl-serine Phosphorylation GTP-dependent Protein Binding MAP Kinase Kinase Kinase Activity Response To Muscle Stretch Regulation Of Peptidyl-serine Phosphorylation Thyroid Gland Development Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Component Biogenesis Establishment Of Endothelial Barrier Endothelial Cell Development Positive Regulation Of Cellular Component Organization Thymus Development Regulation Of Protein Modification Process Gland Development Negative Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Regulation Of Small GTPase Mediated Signal Transduction Protein Serine Kinase Activity Positive Regulation Of Cell Projection Organization Actin Cytoskeleton Organization Insulin Receptor Signaling Pathway Death-inducing Signaling Complex Assembly Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity Intracellular Glucose Homeostasis Regulation Of Rho Protein Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Cellular Component Organization Apoptotic Process Plasma Membrane Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Programmed Cell Death Actin Filament-based Process T Cell Receptor Signaling Pathway Cell Death Hematopoietic Or Lymphoid Organ Development Protein Serine/threonine Kinase Activity Regulation Of Protein Localization Negative Regulation Of Autophagy
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