RASIP1 and RRAS

Number of citations of the paper that reports this interaction (PMID 15031288)
17

Data Source:
HPRD (in vitro, two hybrid)

		RASIP1	RRAS
Gene Name		Ras interacting protein 1	related RAS viral (r-ras) oncogene homolog
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Stack Perinuclear Region Of Cytoplasm	Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome
	Molecular Function		GTPase Activity Protein Binding GTP Binding GDP Binding Protein Complex Binding
	Biological Process	Angiogenesis Vasculogenesis Signal Transduction Negative Regulation Of Autophagy Regulation Of Rho GTPase Activity Branching Morphogenesis Of An Epithelial Tube	Leukocyte Differentiation Ras Protein Signal Transduction Synaptic Transmission Axon Guidance Negative Regulation Of Cell Migration Positive Regulation Of Angiogenesis Regulation Of Protein Kinase B Signaling Face Morphogenesis Regulation Of ERK1 And ERK2 Cascade
Pathways			Axon guidance Semaphorin interactions Activation of NMDA receptor upon glutamate binding and postsynaptic events SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration Sema4D in semaphorin signaling CREB phosphorylation through the activation of Ras Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses Post NMDA receptor activation events
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972) Crohn's disease ( 21102463) Dietary macronutrient intake ( 23372041) Retinal vascular caliber ( 21060863)
Protein-Protein Interactions		8 interactors: ARFGAP1 HRAS LDB2 MRAS RAP1A RAP2A RRAS RRAS2	15 interactors: ACY3 ARAF BCL2 EEF1A1 EPHB2 MLLT4 MRPL36 NAV2 NCK1 PPP2CA RAF1 RALGDS RASIP1 RASSF5 SOS1
Entrez ID		54922	6237
HPRD ID		15214	01299
Ensembl ID		ENSG00000105538	ENSG00000126458
Uniprot IDs		Q5U651 Q7L251 Q8IUR2	P10301
PDB IDs			2FN4
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Rap Protein Signal Transduction Intracellular Signal Transduction Regulation Of Cell Migration Regulation Of Phosphorylation Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Movement Positive Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Signal Transduction Cell Differentiation Activation Of MAPKK Activity Developmental Process Regulation Of Protein Phosphorylation Signaling Positive Regulation Of Cellular Protein Metabolic Process Cell Communication Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Projection Organization Positive Regulation Of Kinase Activity Regulation Of Ras GTPase Activity System Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transferase Activity Cellular Response To Stimulus Positive Regulation Of ERK1 And ERK2 Cascade Actin Cytoskeleton Organization Regulation Of Signal Transduction Actin Filament-based Process Generation Of Neurons Regulation Of Ras Protein Signal Transduction Regulation Of Cell Differentiation Multicellular Organismal Development Neurogenesis Regulation Of JNK Cascade Positive Regulation Of GTPase Activity Anatomical Structure Development Regulation Of Signaling Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Rac Protein Signal Transduction Regulation Of Stress-activated MAPK Cascade	Regulation Of Intracellular Signal Transduction Regulation Of Peptidyl-serine Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Stimulus Regulation Of Cellular Ketone Metabolic Process Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Axonogenesis Positive Regulation Of Peptidyl-serine Phosphorylation Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Response To Growth Factor Signal Transduction Regulation Of Catalytic Activity Neuron Projection Morphogenesis Optic Nerve Development Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Signaling Regulation Of Small GTPase Mediated Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Communication Axon Guidance Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Modification Process Negative Regulation Of Autophagy Positive Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Neuron Development Response To Fibroblast Growth Factor Apoptotic Process Programmed Cell Death Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Cell Death Neurotrophin Signaling Pathway Death Cell Morphogenesis Regulation Of Protein Phosphorylation
Tagcloud ?			10q 19q 19q13 1p astrocytoma astrocytomas carry complementation complementing deletion diffuse ercc1 excision exome favorable fibrillary gemistocytes gemistocytic glioblastoma glioblastomas heterozygosity homolog homozygous idh idh1 neoplastic rodent tended tert
Tagcloud (Difference) ?			10q 19q 19q13 1p astrocytoma astrocytomas carry complementation complementing deletion diffuse ercc1 excision exome favorable fibrillary gemistocytes gemistocytic glioblastoma glioblastomas heterozygosity homolog homozygous idh idh1 neoplastic rodent tended tert
Tagcloud (Intersection) ?