CASZ1 and PALB2

Number of citations: 0 (PubMedID 25640309)
Data Source: BioGRID (two hybrid)

		CASZ1	PALB2
Name		castor zinc finger 1	partner and localizer of BRCA2
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Nucleus Nucleoplasm Nuclear Speck Protein-containing Complex DNA Repair Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding	DNA Binding Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis Inner Cell Mass Cell Proliferation DNA Repair DNA Recombination Apoptotic Process DNA Damage Response Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways		None	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Neddylation Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2 KEAP1-NFE2L2 pathway
Diseases		None	Fanconi anemia
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657 ) Apolipoprotein B levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Atrial fibrillation ( 30061737 29892015 ) Beard thickness ( 26926045 ) Blood pressure ( 21572416 ) Blood urea nitrogen levels ( 31152163 ) Cataracts ( 34127677 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Diastolic blood pressure ( 28739976 29403010 25249183 27618447 27841878 30487518 27618452 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Estimated glomerular filtration rate ( 31152163 31015462 ) Facial morphology ( 31763980 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Hypertension ( 30487518 25249183 ) LDL cholesterol levels ( 32203549 ) Lymphocyte count ( 32888494 ) Male-pattern baldness ( 28196072 ) Mean arterial pressure ( 30487518 27618448 29403010 ) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (antihypertensives) ( 31015401 ) Medication use (beta blocking agents) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Microalbuminuria ( 31511532 ) Monocyte count ( 32888494 ) Neutrophil count ( 32888494 ) Pulse pressure ( 29403010 27841878 28739976 30578418 30487518 ) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962 ) Red blood cell count ( 32888494 ) Resistance to antihypertensive treatment in hypertension ( 31545351 ) Resistant hypertension ( 31545351 ) Systolic blood pressure ( 29403010 27618452 30578418 28739976 19430479 27841878 25249183 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Triglyceride levels ( 32203549 ) Urinary albumin-to-creatinine ratio ( 31511532 26631737 ) White blood cell count ( 32888494 )	Bipolar disorder ( 17554300 )
Interacting Genes		9 interacting genes: APP BAG4 BCAR3 ESR2 PALB2 PPM1D PTPN1 RAF1 WT1	31 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 USP22 XRCC3
Entrez ID		54897	79728
HPRD ID		07897	07966
Ensembl ID		ENSG00000130940	ENSG00000083093
Uniprot IDs		B3KRV8 Q86V15	A0A8V8TLC8 A0A8V8TMK8 A0AAQ5BGU0 H3BN63 I3L1Z5 Q86YC2
PDB IDs		Not available	2W18 3EU7 7S4A 8YAP
GO Terms Enriched among Interactors		Negative Regulation Of Cell Population Proliferation Enzyme Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Insulin Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Regulation Of Cell Population Proliferation Endosome Lumen Insulin Receptor Binding Intracellular Signal Transduction Ephrin Receptor Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Response To Endoplasmic Reticulum Stress Response To Nerve Growth Factor Regulation Of MAPK Cascade Cellular Response To Nerve Growth Factor Stimulus Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Response To Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To CAMP Glial Cell Development Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Negative Regulation Of MRNA Modification Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of MiRNA Transcription ERBB Signaling Pathway Acetylcholine Receptor Activator Activity Negative Regulation Of Metabolic Process Positive Regulation Of Cell Communication Regulation Of MiRNA Metabolic Process Positive Regulation Of Signaling Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Import Response To CAMP Protein Dephosphorylation	Chromatin Remodeling Telomere Maintenance Via Recombination Telomere Organization Chromatin Organization Rad51C-XRCC3 Complex Mitotic Recombination Chromosome, Telomeric Region Positive Regulation Of Cell Cycle Nucleoplasm Chromosome Organization Double-strand Break Repair Interstrand Cross-link Repair DNA Recombination Positive Regulation Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Recombinational Repair Crossover Junction DNA Endonuclease Activity Cornified Envelope Histone H4 Acetyltransferase Activity Protein-DNA Complex Assembly Four-way Junction DNA Binding Structural Constituent Of Chromatin ATP-dependent DNA Damage Sensor Activity DNA Binding Telomere Maintenance Nucleosome Assembly Male Meiosis I