CASZ1 and BAG4

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		CASZ1	BAG4
Description		castor zinc finger 1	BAG cochaperone 4
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding	Adenyl-nucleotide Exchange Factor Activity RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Protein-folding Chaperone Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Protein Folding Positive Regulation Of Fibroblast Migration Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion Protein Stabilization Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Protein Localization To Plasma Membrane Negative Regulation Of MRNA Modification Ruffle Assembly Negative Regulation Of Protein Targeting To Mitochondrion
Pathways			Regulation of HSF1-mediated heat shock response Signaling by FGFR1 in disease TNF signaling Signaling by plasma membrane FGFR1 fusions
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Atrial fibrillation ( 30061737 29892015) Beard thickness ( 26926045) Blood pressure ( 21572416) Blood urea nitrogen levels ( 31152163) Cataracts ( 34127677) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Diastolic blood pressure ( 28739976 29403010 25249183 27618447 27841878 30487518 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163 31015462) Facial morphology ( 31763980) Femur bone mineral density x serum urate levels interaction ( 34046847) Hypertension ( 30487518 25249183) LDL cholesterol levels ( 32203549) Lymphocyte count ( 32888494) Male-pattern baldness ( 28196072) Mean arterial pressure ( 30487518 27618448 29403010) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antihypertensives) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Microalbuminuria ( 31511532) Monocyte count ( 32888494) Neutrophil count ( 32888494) Pulse pressure ( 29403010 27841878 28739976 30578418 30487518) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Red blood cell count ( 32888494) Resistance to antihypertensive treatment in hypertension ( 31545351) Resistant hypertension ( 31545351) Systolic blood pressure ( 29403010 27618452 30578418 28739976 19430479 27841878 25249183) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549) Urinary albumin-to-creatinine ratio ( 31511532 26631737) White blood cell count ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)
Interacting Genes		9 interacting genes: APP BAG4 BCAR3 ESR2 PALB2 PPM1D PTPN1 RAF1 WT1	141 interacting genes: ABI2 ACOT7 ADAMTSL4 ALG13 ANKHD1 APOBEC1 ARID5A ATAD2 ATOSB ATP23 BAP1 BCAS3 BCL2 BCL6B BEX1 BLZF1 BMS1 C3orf38 CASP2 CASZ1 CBFA2T2 CCL5 CEP55 CIMAP1C CPSF7 DDIT4L DIRAS3 DMRTB1 DZIP3 EFEMP1 EIF4ENIF1 EPSTI1 ERRFI1 FAM222B FARS2 FTH1 FYN GLCE GPANK1 GPS2 GRAP2 GRIP1 HOXA1 HSPA1A HSPA1B HSPA1L HSPA2 HSPA6 HSPA8 IL13RA2 IL24 IST1 ITIH5 KCTD6 KCTD7 KIF5B KLK5 KLK7 KLK9 KRT31 KRTAP13-1 KRTAP13-4 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP6-3 LASP1 LRATD2 LYPD3 MAGED1 MEI4 MRC2 MTA3 MYOZ1 MYOZ3 MYPOP NAT2 ODF1 P4HA3 PDCD6 PDLIM2 PEF1 PGRMC2 PHF19 PKP2 PLAC8 PPIL6 PRDM14 PRPF6 PRRC2B PSMB5 PYCR3 QKI RAMAC RASL10B RBFOX2 RBM22 RBM42 RBM7 RBPMS RHOBTB2 RNF20 RPL22 RUNX1 SAMD4A SAXO1 SAXO4 SCGB3A1 SF1 SF3B4 SH3RF2 SIAH1 SNRPA SNRPB SNRPC SNRPN SNW1 SS18L1 SUOX TBC1D3B TBC1D3G TBC1D7 TCL1B TEKT5 TFAP2D TFIP11 THRSP TINAGL1 TLE5 TNFRSF1A TNFRSF25 TRAPPC6A TSG101 UNKL USP22 VIM VPS37C ZBTB45 ZBTB5 ZIM2
Entrez ID		54897	9530
HPRD ID		07897	04861
Ensembl ID		ENSG00000130940	ENSG00000156735
Uniprot IDs		B3KRV8 Q86V15	O95429
PDB IDs			1M62 1M7K
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Population Proliferation Enzyme Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Insulin Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Regulation Of Cell Population Proliferation Endosome Lumen Insulin Receptor Binding Intracellular Signal Transduction Ephrin Receptor Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Response To Endoplasmic Reticulum Stress Response To Nerve Growth Factor Regulation Of MAPK Cascade Cellular Response To Nerve Growth Factor Stimulus Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Response To Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To CAMP Glial Cell Development Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Negative Regulation Of MRNA Modification Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of MiRNA Transcription ERBB Signaling Pathway Acetylcholine Receptor Activator Activity Negative Regulation Of Metabolic Process Positive Regulation Of Cell Communication Regulation Of MiRNA Metabolic Process Positive Regulation Of Signaling Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Import Response To CAMP Protein Dephosphorylation	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex Protein Refolding MRNA Metabolic Process MRNA Processing ATP-dependent Protein Folding Chaperone Intermediate Filament RNA Binding RNA Splicing Protein Binding Hair Cycle C3HC4-type RING Finger Domain Binding Transcription Corepressor Activity ATP-dependent Protein Disaggregase Activity Protein Folding Chaperone Cellular Heat Acclimation Nucleus Heat Shock Protein Binding U1 SnRNP U4/U6 X U5 Tri-snRNP Complex Regulation Of RNA Splicing RNA Processing RNA Metabolic Process Negative Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Catalytic Step 2 Spliceosome Regulation Of MRNA Metabolic Process Identical Protein Binding Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Inclusion Body Assembly Keratin Filament Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Post-translational Protein Modification SnRNP Binding Negative Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding MRNA Binding Response To Temperature Stimulus Nucleic Acid Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome U2-type Prespliceosome Unfolded Protein Binding Positive Regulation Of Antibacterial Peptide Production Epidermal Lamellar Body Macromolecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Calcium-dependent Protein Binding Blood Microparticle
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