CASZ1

Name	castor zinc finger 1
Structure	No pdb structure
Interactors	9 interactors: APP BAG4 BCAR3 ESR2 PALB2 PPM1D PTPN1 RAF1 WT1
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
GWAS	Allergic disease (asthma, hay fever or eczema) ( 29679657 ) Apolipoprotein B levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Atrial fibrillation ( 30061737 29892015 ) Beard thickness ( 26926045 ) Blood pressure ( 21572416 ) Blood urea nitrogen levels ( 31152163 ) Cataracts ( 34127677 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Diastolic blood pressure ( 28739976 29403010 25249183 27618447 27841878 30487518 27618452 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Estimated glomerular filtration rate ( 31152163 31015462 ) Facial morphology ( 31763980 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Hypertension ( 30487518 25249183 ) LDL cholesterol levels ( 32203549 ) Lymphocyte count ( 32888494 ) Male-pattern baldness ( 28196072 ) Mean arterial pressure ( 30487518 27618448 29403010 ) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (antihypertensives) ( 31015401 ) Medication use (beta blocking agents) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Microalbuminuria ( 31511532 ) Monocyte count ( 32888494 ) Neutrophil count ( 32888494 ) Pulse pressure ( 29403010 27841878 28739976 30578418 30487518 ) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962 ) Red blood cell count ( 32888494 ) Resistance to antihypertensive treatment in hypertension ( 31545351 ) Resistant hypertension ( 31545351 ) Systolic blood pressure ( 29403010 27618452 30578418 28739976 19430479 27841878 25249183 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Triglyceride levels ( 32203549 ) Urinary albumin-to-creatinine ratio ( 31511532 26631737 ) White blood cell count ( 32888494 )
Entrez ID	54897
HPRD ID	07897
Ensembl ID	ENSG00000130940
Uniprot IDs	B3KRV8 Q86V15
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Negative Regulation Of Cell Population Proliferation Enzyme Binding Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Insulin Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of MAPK Cascade Regulation Of Cell Population Proliferation Endosome Lumen Insulin Receptor Binding Intracellular Signal Transduction Ephrin Receptor Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Response To Endoplasmic Reticulum Stress Response To Nerve Growth Factor Regulation Of MAPK Cascade Cellular Response To Nerve Growth Factor Stimulus Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium Epigenetic Regulation Of Gene Expression Regulation Of Response To Calcium Ion Response To Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To CAMP Glial Cell Development Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Negative Regulation Of MRNA Modification Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of MiRNA Transcription ERBB Signaling Pathway Acetylcholine Receptor Activator Activity Negative Regulation Of Metabolic Process Positive Regulation Of Cell Communication Regulation Of MiRNA Metabolic Process Positive Regulation Of Signaling Regulation Of Response To Endoplasmic Reticulum Stress Lipoprotein Particle Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Import Response To CAMP Protein Dephosphorylation