NDE1 and USHBP1

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		NDE1	USHBP1
Description		nudE neurodevelopment protein 1	USH1 protein network component harmonin binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Spindle Pole Centrosome Cleavage Furrow Synapse
	Molecular Function	Protein Binding Microtubule Binding Protein Domain Specific Binding Identical Protein Binding	Protein Binding PDZ Domain Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Neuron Migration Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Nervous System Development Neuroblast Proliferation Cell Migration Cerebral Cortex Development Cell Differentiation Forebrain Development Microtubule Organizing Center Organization Vesicle Transport Along Microtubule Chromosome Localization Centrosome Duplication Cell Division Centrosome Localization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Mean platelet volume ( 32888494) Multiple system atrophy (pathologically confirmed) ( 27629089) Serum immune biomarker levels ( 32066700) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Mitochondrial DNA copy number ( 30704525)
Interacting Genes		27 interacting genes: AR ARNT2 CDK1 DISC1 FAM9B FBXO7 GOLGA2 HOXA2 LZTS2 MAPK1 MED4 MKRN3 NDC80 PAFAH1B1 REL TFIP11 TRIM27 TSPOAP1 TTC1 TUBG1 UBQLN1 USHBP1 WAC YWHAG YWHAQ ZNF365 ZNF398	234 interacting genes: ABHD11 ABI2 ABLIM1 ACMSD AIRIM AKAP9 ANKRD33 ANKRD36BP1 ARFIP2 ARMC5 ARNT2 ASB15 ATP5PO BCAS2 BCL10 BCL2L11 BET1 BEX2 BEX3 BFSP1 BFSP2 BICRAL BLOC1S1 BLZF1 BORCS6 BRAT1 BRPF1 C1orf216 C21orf58 CBY2 CCDC116 CCDC120 CCDC121 CCDC146 CCDC148 CCDC187 CCDC196 CCDC197 CCDC22 CCDC24 CCDC28A CCDC33 CCDC42 CCDC87 CCHCR1 CCNK CDC37 CDC5L CDKN1A CENPP CEP63 CEP68 CFAP206 CHCHD3 CNNM3 COPS4 COPS6 COPS8 CTNNA3 CTNNBIP1 CTTNBP2NL CYTH4 DCTN2 DCTN3 DEPP1 DEUP1 DNAAF19 DRC4 DTNB DYDC1 EIF4E2 ENKD1 ERCC1 EXOC7 EXOC8 FAM107A FAM110A FAM124B FAM161B FANCG FATE1 FBF1 FCHSD2 FCRL5 FTL GATAD2B GCC1 GEM GFI1B GIT2 GMCL2 GNG4 GOLGA6L9 GOLGA8EP GOLGA8F GPSM1 GPSM3 GTF2H1 HAUS1 HAUS8 HGS HMG20A HMG20B HYI IFT20 IL16 IMP3 ING3 INPP1 INTS4 ITGB3BP KANK2 KANSL1 KIAA0753 KLC3 KLC4 KLHL38 KLHL42 KPNA2 KRT14 KRT15 KRT16 KRT19 KRT20 KRT26 KRT27 KRT28 KRT31 KRT37 KRT38 KRT40 KRT71 KRT75 KRT79 LENG1 LINC00526 MAGEB4 MCCD1 MCM7 MCRS1 MED11 MED28 MED4 MEI4 METTL15 MIIP MKRN3 MNS1 MOS MRPS23 MXI1 MYOG MYOZ1 NCAPH2 NDC80 NDE1 NECAB2 NEFL NOC4L NUP62 ODAD3 OIP5 PARVG PAX6 PBX4 PICK1 PKN1 PKNOX2 PMF1 POLM POP5 PPP1R12C PPP1R7 PPP2R5A PPP2R5D PRC1 PRKAA2 PRR5 QARS1 RASAL2 RCOR3 RECK RIBC1 RIBC2 RINT1 RNF20 RTP5 SAPCD2 SAT1 SCNM1 SCT SEC14L4 SEMA4C SERTAD3 SH2D4A SHC3 SMARCD1 SMARCE1 SOHLH1 SPG21 SRI STX11 SYNJ2BP TASOR2 TCEANC TCHP TEKT1 THADA THOC1 TIMM13 TPRX1 TRIM54 TRIML2 TSG101 TTC23 TTC9C TTLL10 TUBGCP4 TXLNA TXLNB UBE2W UBXN11 USH1C USP2 VPS28 ZBTB42 ZFHX3 ZFYVE26 ZNF417 ZNF483 ZNF655 ZNF688 ZNF765 ZNRF2P1
Entrez ID		54820	83878
HPRD ID		14815	18276
Ensembl ID		ENSG00000072864	ENSG00000130307
Uniprot IDs		Q9NXR1 X5DP35 X5DR54	B4DUE8 G8JLM4 Q8N6Y0 Q8N8Y1
PDB IDs		7E1T
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Organization Involved In Mitosis Centrosome Microtubule Cytoskeleton Organization Meiotic Spindle Organization Identical Protein Binding Central Region Of Growth Cone Golgi Disassembly Radial Glia-guided Pyramidal Neuron Migration Positive Regulation Of Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cytoplasm Nucleus Nuclear Membrane Disassembly Chromosome Organization Microtubule-based Process Microtubule Meiotic Spindle Assembly Membrane Disassembly Regulation Of Autophagy Intracellular Signal Transduction Microtubule Organizing Center Organization Negative Regulation Of Mitotic Cell Cycle Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Animal Organ Formation MAPK Cascade Peptidyl-threonine Phosphorylation Negative Regulation Of Cell Cycle Phase Transition Spindle Mitotic Spindle Organization Positive Regulation Of Neuroinflammatory Response Cell Division Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Organelle Assembly Organelle Organization Prostate Induction Regulation Of Developmental Growth Nucleoplasm Regulation Of Cell Communication Regulation Of Signal Transduction Animal Organ Morphogenesis Regulation Of Macromolecule Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Signaling Regulation Of Metabolic Process	Cytoskeleton Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Structural Constituent Of Skin Epidermis Keratin Filament Protein Binding Cytoskeleton Organization Intermediate Filament Microtubule-based Process Organelle Organization Structural Molecule Activity Microtubule Cytoskeleton Organization Centrosome Supramolecular Fiber Organization Cytoplasm Structural Constituent Of Cytoskeleton Spindle Pole Establishment Of Spindle Orientation Microtubule Organizing Center Organization Establishment Of Mitotic Spindle Orientation Epithelial Cell Differentiation Establishment Of Spindle Localization Establishment Of Mitotic Spindle Localization Spindle Localization Motile Cilium Organelle Localization Chromosome, Centromeric Region Centriole Kinetochore Microtubule-based Movement Positive Regulation Of Ubiquitin-dependent Endocytosis Morphogenesis Of An Epithelium Microtubule Axonemal A Tubule Inner Sheath Negative Regulation Of Cell Cycle Phase Transition Establishment Of Organelle Localization Membrane Fission Protein Deneddylation CENP-A Containing Chromatin Assembly Ciliary Basal Body Microtubule Cytoskeleton Organization Involved In Mitosis Spindle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cis-Golgi Network Centrosome Cycle Regulation Of Post-translational Protein Modification Cilium Movement Centriole Assembly Cilium
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