NDE1 and MED4

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		NDE1	MED4
Description		nudE neurodevelopment protein 1	mediator complex subunit 4
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Spindle Pole Centrosome Cleavage Furrow Synapse	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex
	Molecular Function	Protein Binding Microtubule Binding Protein Domain Specific Binding Identical Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Vitamin D Receptor Binding Nuclear Thyroid Hormone Receptor Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Neuron Migration Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Nervous System Development Neuroblast Proliferation Cell Migration Cerebral Cortex Development Cell Differentiation Forebrain Development Microtubule Organizing Center Organization Vesicle Transport Along Microtubule Chromosome Localization Centrosome Duplication Cell Division Centrosome Localization	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Mean platelet volume ( 32888494) Multiple system atrophy (pathologically confirmed) ( 27629089) Serum immune biomarker levels ( 32066700) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Proportion of activated microglia (inferior temporal cortex) ( 30679421) Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		27 interacting genes: AR ARNT2 CDK1 DISC1 FAM9B FBXO7 GOLGA2 HOXA2 LZTS2 MAPK1 MED4 MKRN3 NDC80 PAFAH1B1 REL TFIP11 TRIM27 TSPOAP1 TTC1 TUBG1 UBQLN1 USHBP1 WAC YWHAG YWHAQ ZNF365 ZNF398	41 interacting genes: AMOT AP2M1 ATF7IP ATF7IP2 C1orf216 CCDC146 CCHCR1 CEBPA CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD GCC1 HAUS1 HGS IP6K3 ITSN1 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 OIP5 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 TLE5 TNFAIP8 TNFAIP8L1 USHBP1 WDTC1 WWP2
Entrez ID		54820	29079
HPRD ID		14815	16145
Ensembl ID		ENSG00000072864	ENSG00000136146
Uniprot IDs		Q9NXR1 X5DP35 X5DR54	Q9NPJ6
PDB IDs		7E1T	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Organization Involved In Mitosis Centrosome Microtubule Cytoskeleton Organization Meiotic Spindle Organization Identical Protein Binding Central Region Of Growth Cone Golgi Disassembly Radial Glia-guided Pyramidal Neuron Migration Positive Regulation Of Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cytoplasm Nucleus Nuclear Membrane Disassembly Chromosome Organization Microtubule-based Process Microtubule Meiotic Spindle Assembly Membrane Disassembly Regulation Of Autophagy Intracellular Signal Transduction Microtubule Organizing Center Organization Negative Regulation Of Mitotic Cell Cycle Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Animal Organ Formation MAPK Cascade Peptidyl-threonine Phosphorylation Negative Regulation Of Cell Cycle Phase Transition Spindle Mitotic Spindle Organization Positive Regulation Of Neuroinflammatory Response Cell Division Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Organelle Assembly Organelle Organization Prostate Induction Regulation Of Developmental Growth Nucleoplasm Regulation Of Cell Communication Regulation Of Signal Transduction Animal Organ Morphogenesis Regulation Of Macromolecule Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Signaling Regulation Of Metabolic Process	Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Transcription Coregulator Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of RNA Metabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Modification Of Postsynaptic Structure Brahma Complex NBAF Complex RSC-type Complex NpBAF Complex Kinetochore Centrosome Regulation Of DNA-templated Transcription Initiation Regulation Of Exosomal Secretion Regulation Of Modification Of Synaptic Structure Nucleosome Disassembly Regulation Of Embryonic Development
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