NDE1

Name	nudE neurodevelopment protein 1
Structure
Novel Interactors	1 novel interactors: NOMO1
Interactors	27 interactors: AR ARNT2 CDK1 DISC1 FAM9B FBXO7 GOLGA2 HOXA2 LZTS2 MAPK1 MED4 MKRN3 NDC80 PAFAH1B1 REL TFIP11 TRIM27 TSPOAP1 TTC1 TUBG1 UBQLN1 USHBP1 WAC YWHAG YWHAQ ZNF365 ZNF398
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Spindle Pole Centrosome Cleavage Furrow Synapse
	Molecular Function	Protein Binding Microtubule Binding Protein Domain Specific Binding Identical Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Neuron Migration Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Nervous System Development Neuroblast Proliferation Cell Migration Cerebral Cortex Development Cell Differentiation Forebrain Development Microtubule Organizing Center Organization Vesicle Transport Along Microtubule Chromosome Localization Centrosome Duplication Cell Division Centrosome Localization
Pathways	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
GWAS	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Mean platelet volume ( 32888494 ) Multiple system atrophy (pathologically confirmed) ( 27629089 ) Serum immune biomarker levels ( 32066700 ) Serum uric acid levels in response to allopurinol in gout ( 25676789 )
Entrez ID	54820
HPRD ID	14815
Ensembl ID	ENSG00000072864
Uniprot IDs	Q9NXR1 X5DP35 X5DR54
PDB IDs	7E1T
GO Terms Enriched among Interactors ?	Microtubule Cytoskeleton Organization Involved In Mitosis Centrosome Microtubule Cytoskeleton Organization Meiotic Spindle Organization Identical Protein Binding Central Region Of Growth Cone Golgi Disassembly Radial Glia-guided Pyramidal Neuron Migration Positive Regulation Of Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cytoplasm Nucleus Nuclear Membrane Disassembly Chromosome Organization Microtubule-based Process Microtubule Meiotic Spindle Assembly Membrane Disassembly Regulation Of Autophagy Intracellular Signal Transduction Microtubule Organizing Center Organization Negative Regulation Of Mitotic Cell Cycle Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Animal Organ Formation MAPK Cascade Peptidyl-threonine Phosphorylation Negative Regulation Of Cell Cycle Phase Transition Spindle Mitotic Spindle Organization Positive Regulation Of Neuroinflammatory Response Cell Division Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cytoskeleton Organization Organelle Assembly Organelle Organization Prostate Induction Regulation Of Developmental Growth Nucleoplasm Regulation Of Cell Communication Regulation Of Signal Transduction Animal Organ Morphogenesis Regulation Of Macromolecule Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Signaling Regulation Of Metabolic Process