NDE1 and NDC80

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		NDE1	NDC80
Gene Name		nudE neurodevelopment protein 1	NDC80 kinetochore complex component
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Centrosome Cytosol Kinesin Complex Microtubule Membrane Spindle Pole Centrosome Cleavage Furrow	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Nucleus Cytosol Membrane Ndc80 Complex
	Molecular Function	Protein Binding Microtubule Binding Protein Domain Specific Binding Identical Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Neuron Migration Organelle Organization Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Neuroblast Proliferation Cell Migration Cerebral Cortex Development Vesicle Transport Along Microtubule Centrosome Duplication Cell Division Establishment Of Chromosome Localization Centrosome Localization	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Mitotic Nuclear Division Attachment Of Spindle Microtubules To Kinetochore Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore
Pathways		Mitotic Prometaphase Organelle biogenesis and maintenance Separation of Sister Chromatids Assembly of the primary cilium G2/M Transition Mitotic Anaphase Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane M Phase Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Resolution of Sister Chromatid Cohesion Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Recruitment of mitotic centrosome proteins and complexes	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: AR ARNT2 BZRAP1 CDK1 DISC1 FAM9B GOLGA2 HOXA2 LZTS2 MAPK1 MED4 MKRN3 NDC80 NDEL1 PAFAH1B1 REL TFIP11 TRIM27 TTC1 TUBG1 UBQLN1 USHBP1 WAC YWHAG YWHAQ ZNF365 ZNF398	45 interactors: AMOTL2 ATF4 ATP5O AURKA AURKB BLOC1S6 CALCOCO1 CCDC101 CCDC53 CCHCR1 CCNH CCNK CENPH HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MED4 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PFDN1 PSMC2 RB1 RUFY4 SFR1 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 ZWINT
Entrez ID		54820	10403
HPRD ID		14815	06277
Ensembl ID		ENSG00000072864	ENSG00000080986
Uniprot IDs		Q9NXR1	A8K031 O14777
PDB IDs			2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Organization Cell Cycle Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle Process G2/M Transition Of Mitotic Cell Cycle Microtubule-based Process Nuclear Envelope Disassembly Cellular Localization Positive Regulation Of Macromolecule Biosynthetic Process Cytoskeleton Organization Establishment Of Mitotic Spindle Orientation Positive Regulation Of Gene Expression Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Mitotic Nuclear Division Positive Regulation Of Cellular Biosynthetic Process Retrograde Axon Cargo Transport Spindle Localization Positive Regulation Of Transcription, DNA-templated Regulation Of Signal Transduction Cerebral Cortex Radially Oriented Cell Migration Nuclear Envelope Organization Regulation Of Cellular Localization Regulation Of Neurogenesis Organ Development Cell Proliferation Regulation Of Signaling Regulation Of Metabolic Process Establishment Of Localization In Cell Brain Development Cerebral Cortex Cell Migration Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Localization Head Development Mitotic Cell Cycle Phase Transition Telencephalon Cell Migration Cell Cycle Phase Transition Forebrain Cell Migration Regulation Of Cell Development Axonogenesis Positive Regulation Of Signal Transduction Regulation Of Neuron Differentiation Microtubule Organizing Center Organization Establishment Of Cell Polarity Positive Regulation Of Metabolic Process Microtubule Nucleation Axon Development Nervous System Development Nucleus Organization	Mitotic Nuclear Division Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Division Cell Cycle Chromosome Segregation Cell Cycle Process Negative Regulation Of Cell Cycle Centrosome Separation Organelle Organization Regulation Of Cell Cycle Microtubule-based Process Regulation Of Cell Cycle Process Mitotic Spindle Organization Regulation Of Mitotic Cell Cycle Cellular Localization Mitotic Centrosome Separation Microtubule Cytoskeleton Organization Regulation Of Mitotic Nuclear Division Centrosome Localization Spindle Organization Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Division Mitotic Sister Chromatid Segregation Regulation Of Chromosome Segregation Mitotic Cell Cycle Checkpoint Sister Chromatid Segregation Centrosome Organization Organelle Localization Establishment Of Localization In Cell Microtubule Organizing Center Organization Centrosome Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Intracellular Transport Chromosome Organization Negative Regulation Of Cell Division Spindle Assembly Organelle Assembly Spindle Stabilization Cytoskeleton Organization Protein Localization To Chromosome Establishment Of Organelle Localization Regulation Of Organelle Organization Establishment Of Vesicle Localization Protein Localization To Organelle
Tagcloud ?		breaks catastrophic cohesin completing concurrent discovered disorders ensures evoked fate genomic heterochromatin impediment indispensible integrity layer mid neural neurological pool progenitor progenitors remodeler replication restrictive safeguarding stalled steps strand	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Difference) ?		breaks catastrophic cohesin completing concurrent discovered disorders ensures evoked fate genomic heterochromatin impediment indispensible integrity layer mid neural neurological pool progenitor progenitors remodeler replication restrictive safeguarding stalled steps strand	assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mis12 mitosis orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus
Tagcloud (Intersection) ?