TSFM and CCDC89

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TSFM	CCDC89
Description		Ts translation elongation factor, mitochondrial	coiled-coil domain containing 89
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Intracellular Organelle Lumen	Nucleus Cytoplasm
	Molecular Function	RNA Binding Translation Elongation Factor Activity Protein Binding	Protein Binding
	Biological Process	Translation Translational Elongation Mitochondrial Translational Elongation
Pathways		Mitochondrial translation elongation
Drugs
Diseases		Combined oxidative phosphorylation deficiency (COXPD)
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 24076602)	Age at first sexual intercourse ( 34211149) Refractive error ( 32231278)
Interacting Genes		12 interacting genes: CCDC89 CDC42 CEP70 CPLX2 DRC4 GOLGA6L9 KRTAP1-1 LIG4 MDFI MTRNR2L1 PPP1R12C RALBP1	5 interacting genes: BMPR2 FAM50B LRRC45 PIK3R3 TSFM
Entrez ID		10102	220388
HPRD ID		05285	08234
Ensembl ID		ENSG00000123297	ENSG00000179071
Uniprot IDs		E5KS95 P43897	Q8N998
PDB IDs		2CP9	8WQA 8WQB 8WQD 8WQH
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Chondrocyte Proliferation Regulation Of Lung Blood Pressure Aortic Valve Development Lymphatic Endothelial Cell Differentiation BMP Receptor Activity Pulmonary Valve Development Tricuspid Valve Morphogenesis Venous Blood Vessel Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Activin Receptor Activity, Type II Endochondral Bone Morphogenesis Transforming Growth Factor Beta Receptor Activity Semi-lunar Valve Development Mitral Valve Morphogenesis 1-phosphatidylinositol-3-kinase Regulator Activity Phosphatidylinositol 3-kinase Complex Mitochondrial Translational Elongation Maternal Placenta Development Lung Vasculature Development Pharyngeal Arch Artery Morphogenesis Endothelial Cell Apoptotic Process 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Complex, Class IA Transmembrane Receptor Protein Serine/threonine Kinase Activity Negative Regulation Of Vasoconstriction Endocardial Cushion Development Intracellular Organelle Lumen Lymphangiogenesis Retina Vasculature Development In Camera-type Eye Regulation Of Axon Extension Involved In Axon Guidance Atrial Septum Morphogenesis
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