TSFM and DRC4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TSFM	DRC4
Description		Ts translation elongation factor, mitochondrial	dynein regulatory complex subunit 4
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Intracellular Organelle Lumen	Extracellular Region Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Motile Cilium Ciliary Basal Body Sperm Flagellum Cell Projection 9+2 Motile Cilium
	Molecular Function	RNA Binding Translation Elongation Factor Activity Protein Binding	Protein Binding Microtubule Binding Small GTPase Binding
	Biological Process	Translation Translational Elongation Mitochondrial Translational Elongation	Microtubule Cytoskeleton Organization Epithelial Cilium Movement Involved In Extracellular Fluid Movement Determination Of Left/right Symmetry Brain Development Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Flagellated Sperm Motility Axoneme Assembly Positive Regulation Of Smoothened Signaling Pathway Cell Motility Establishment Of Localization In Cell Cilium Movement Involved In Cell Motility Positive Regulation Of Protein Localization To Cilium
Pathways		Mitochondrial translation elongation	Activation of SMO
Drugs
Diseases		Combined oxidative phosphorylation deficiency (COXPD)
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 24076602)
Interacting Genes		12 interacting genes: CCDC89 CDC42 CEP70 CPLX2 DRC4 GOLGA6L9 KRTAP1-1 LIG4 MDFI MTRNR2L1 PPP1R12C RALBP1	110 interacting genes: ARL6IP1 BCAR3 BORCS6 BYSL C1orf35 CARD10 CARD9 CBFA2T3 CCDC125 CCDC146 CCDC6 CCHCR1 CCNG1 CDC37 CDR2 CEP70 CFAP53 CINP CKS1B COG6 CPSF7 CRYBB1 CT45A1 CWF19L2 CYSRT1 DAXX DDX17 DISC1 DMAP1 EAF1 EHHADH EIF1AD ERCC1 EVI5L FAM161A FAM161B FHL2 GADD45GIP1 GCC1 GEM GOLGA2 GPRASP3 GRIPAP1 GSTA4 HEXIM2 HOMER3 HOMEZ HOXA1 HSF2BP IGFBP6 KDM1A KRT14 KRT15 KRT16 L3MBTL2 L3MBTL3 LASP1 LHX3 LMO1 LMO2 LZTS1 MAD1L1 MFAP1 MID2 MRFAP1L1 NDOR1 NKAPD1 PLK4 PNKP PNMA5 POLR1C POTEB3 PPFIA1 PRDM14 PRMT5 PRPF18 RALBP1 RBAK RINT1 RUBCN SCNM1 SKIL SORBS3 SP7 SPATA18 SPG21 STAC3 TCEA2 THAP1 TNFAIP3 TRAF2 TRAF5 TRIM41 TRIM54 TSFM TSGA10IP TXLNA TXLNB USHBP1 YES1 YJU2 ZBTB22 ZBTB26 ZBTB39 ZNF212 ZNF250 ZNF572 ZNF620 ZNF629 ZNF792
Entrez ID		10102	2622
HPRD ID		05285	05533
Ensembl ID		ENSG00000123297	ENSG00000141013
Uniprot IDs		E5KS95 P43897	A0A087WZT7 A0A384MR00 B7Z1U9 O95995
PDB IDs		2CP9	8J07
Enriched GO Terms of Interacting Partners?			Identical Protein Binding Protein Binding Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling
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