TSFM and CPLX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TSFM	CPLX2
Description		Ts translation elongation factor, mitochondrial	complexin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Intracellular Organelle Lumen	Nucleus Cytoplasm Cytosol Dendrite SNARE Complex Cell Projection Neuronal Cell Body Terminal Bouton Perikaryon Calyx Of Held Synapse Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-3-complexin Complex Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Binding Translation Elongation Factor Activity Protein Binding	SNARE Binding Protein Binding Syntaxin-1 Binding Syntaxin Binding Calcium-dependent Protein Binding
	Biological Process	Translation Translational Elongation Mitochondrial Translational Elongation	Neurotransmitter Transport Exocytosis Vesicle Docking Involved In Exocytosis Nervous System Development Synaptic Vesicle Exocytosis Regulation Of Exocytosis Cell Differentiation Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Positive Regulation Of Synaptic Plasticity Mast Cell Degranulation Modulation Of Chemical Synaptic Transmission
Pathways		Mitochondrial translation elongation
Drugs
Diseases		Combined oxidative phosphorylation deficiency (COXPD)
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 24076602)	Age-related nuclear cataracts ( 24951543) Chronotype ( 30696823) Obesity-related traits ( 23251661)
Interacting Genes		12 interacting genes: CCDC89 CDC42 CEP70 CPLX2 DRC4 GOLGA6L9 KRTAP1-1 LIG4 MDFI MTRNR2L1 PPP1R12C RALBP1	7 interacting genes: APP MYG1 NDRG4 PBX3 STX2 STX3 TSFM
Entrez ID		10102	10814
HPRD ID		05285	09234
Ensembl ID		ENSG00000123297	ENSG00000145920
Uniprot IDs		E5KS95 P43897	Q6PUV4
PDB IDs		2CP9
Enriched GO Terms of Interacting Partners?			Vesicle Docking Membrane Docking Organelle Localization By Membrane Tethering Locomotory Behavior SNAP Receptor Activity SNARE Complex Amyloid-beta Complex Growth Cone Lamellipodium Visual Behavior Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Visual Learning SNARE Binding Posterior Compartment Specification Anterior Compartment Pattern Formation Adult Locomotory Behavior Acetylcholine Receptor Activator Activity Associative Learning Lipoprotein Particle Positive Regulation Of Protein Import Organelle Membrane Fusion Organelle Localization Vesicle Fusion Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Organelle Fusion Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Chemotaxis Anatomical Structure Morphogenesis Adult Behavior Cellular Response To Norepinephrine Stimulus Growth Cone Positive Regulation Of Synaptic Transmission Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Membrane Fusion Compartment Pattern Specification Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation
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