POLR1A

Gene Name		polymerase (RNA) I polypeptide A, 194kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus DNA-directed RNA Polymerase I Complex Cytoplasm
	Molecular Function	RNA Polymerase I Activity DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS
Protein-protein Interactions		7 interactors: ANP32B NFKBIB NOLC1 POLR1E REL RRN3 TCF4
Entrez ID		25885
HPRD ID		10161
Ensembl ID		ENSG00000068654
Uniprot IDs		O95602 Q9H6T2
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleolus Organization Positive Regulation Of Protein Export From Nucleus Protein-DNA Complex Assembly DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase I Promoter Regulation Of Protein Export From Nucleus Transcription From RNA Polymerase I Promoter RNA Metabolic Process Positive Regulation Of Cytokine Production Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Type I Interferon Production Nucleobase-containing Compound Metabolic Process Regulation Of Cytokine Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Nucleocytoplasmic Transport Cellular Nitrogen Compound Metabolic Process Nucleus Organization Regulation Of Cell Death RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Cellular Macromolecular Complex Assembly Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Intracellular Protein Transport Gene Expression Maintenance Of DNA Repeat Elements Innate Immune Response Cellular Macromolecule Biosynthetic Process Ribosome Biogenesis Macromolecule Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Embryonic Genitalia Morphogenesis Positive Regulation Of Intracellular Transport Negative Regulation Of Cell Death Cytoplasm Organization Myoblast Fate Commitment Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Protein Transport Secretory Granule Localization Hindgut Morphogenesis Insulin Metabolic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Cellular Metabolic Process
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