POLR1A and NOLC1

Number of citations of the paper that reports this interaction (PMID 10567578)
15

Data Source:
HPRD (in vivo, in vitro)

		POLR1A	NOLC1
Gene Name		polymerase (RNA) I polypeptide A, 194kDa	nucleolar and coiled-body phosphoprotein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus DNA-directed RNA Polymerase I Complex Cytoplasm	Nucleoplasm Nucleolus Cytoplasm Cajal Body
	Molecular Function	RNA Polymerase I Activity DNA Binding Protein Binding Zinc Ion Binding	Protein Binding ATP Binding GTP Binding Poly(A) RNA Binding
	Biological Process	Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	RRNA Processing Nucleolus Organization Cell Cycle Mitotic Nuclear Division
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ANP32B NFKBIB NOLC1 POLR1E REL RRN3 TCF4	13 interactors: APP CEBPB COIL CSNK2A1 CSNK2B E2F4 ERG GTF2B POLR1A PRKACA USP4 YWHAG YWHAQ
Entrez ID		25885	9221
HPRD ID		10161	03864
Ensembl ID		ENSG00000068654	ENSG00000166197
Uniprot IDs		O95602 Q9H6T2	Q14978
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleolus Organization Positive Regulation Of Protein Export From Nucleus Protein-DNA Complex Assembly DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase I Promoter Regulation Of Protein Export From Nucleus Transcription From RNA Polymerase I Promoter RNA Metabolic Process Positive Regulation Of Cytokine Production Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Type I Interferon Production Nucleobase-containing Compound Metabolic Process Regulation Of Cytokine Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Nucleocytoplasmic Transport Cellular Nitrogen Compound Metabolic Process Nucleus Organization Regulation Of Cell Death RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Cellular Macromolecular Complex Assembly Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Intracellular Protein Transport Gene Expression Maintenance Of DNA Repeat Elements Innate Immune Response Cellular Macromolecule Biosynthetic Process Ribosome Biogenesis Macromolecule Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Embryonic Genitalia Morphogenesis Positive Regulation Of Intracellular Transport Negative Regulation Of Cell Death Cytoplasm Organization Myoblast Fate Commitment Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Protein Transport Secretory Granule Localization Hindgut Morphogenesis Insulin Metabolic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Cellular Metabolic Process	Regulation Of Metabolic Process Gene Expression Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process RNA Metabolic Process Nervous System Development Negative Regulation Of Protein Metabolic Process Cell Differentiation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Multicellular Organismal Development Apoptotic Process Regulation Of Gene Expression Programmed Cell Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Death Intrinsic Apoptotic Signaling Pathway Death Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Chemotaxis DNA-templated Transcription, Initiation Regulation Of Cellular Protein Metabolic Process Developmental Process Positive Regulation Of Intracellular Transport System Development Positive Regulation Of Signal Transduction Regulation Of Blood Vessel Endothelial Cell Migration Cardiac Conduction Regulation Of Proteolysis Regulation Of Binding Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle Phase Transition Protein Phosphorylation Cell Cycle Positive Regulation Of Transport Regulation Of Protein Kinase Activity Positive Regulation Of Mitochondrion Organization Nucleobase-containing Compound Metabolic Process Transcription, DNA-templated Negative Regulation Of Catalytic Activity Regulation Of Apoptotic Process Regulation Of Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Potassium Ion Export RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process
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