POLR1A and DYDC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POLR1A	DYDC2
Description		RNA polymerase I subunit A	DPY30 domain containing 2
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Chromatin Nucleus Nucleoplasm Chromosome Nucleolus RNA Polymerase I Complex	Set1C/COMPASS Complex
	Molecular Function	Magnesium Ion Binding DNA Binding Chromatin Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity 5'-3' RNA Polymerase Activity Metal Ion Binding DNA/RNA Hybrid Binding	Protein Binding
	Biological Process	DNA-templated Transcription Transcription By RNA Polymerase I Nucleolar Large RRNA Transcription By RNA Polymerase I Negative Regulation Of Protein Localization To Nucleolus
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Facial emotion recognition (sad faces) ( 28608620)	Estimated glomerular filtration rate ( 31451708) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848)
Interacting Genes		10 interacting genes: ANP32B DYDC2 MEOX2 NFKBIB NOLC1 POLR1E PTEN RRN3 SKP2 TCF4	5 interacting genes: DPY30 NME5 POLR1A TENT5D UBXN2A
Entrez ID		25885	84332
HPRD ID		10161	11311
Ensembl ID		ENSG00000068654	ENSG00000133665
Uniprot IDs		O95602	A0A0A0MRQ7 Q96IM9
PDB IDs		7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43	8J07
Enriched GO Terms of Interacting Partners?		Protein-DNA Complex Assembly Nucleolus Organization Transcription Initiation At RNA Polymerase I Promoter RNA Polymerase I Preinitiation Complex Assembly RNA Polymerase Binding Molecular Function Inhibitor Activity Nucleolus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Synaptic Vesicle Clustering Transcription Preinitiation Complex Assembly RNA Polymerase I General Transcription Initiation Factor Binding Positive Regulation Of Macromolecule Metabolic Process Roof Of Mouth Development Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of Adaptive Immune Memory Response DNA-templated Transcription Initiation Nucleus Organization Beta-catenin Binding Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Beta-catenin-TCF7L2 Complex RNA Polymerase I Core Binding Positive Regulation Of Metabolic Process
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