POLR1A and POLR1E

Number of citations of the paper that reports this interaction (PMID 15226435)
10

Data Source:
HPRD (in vitro)

		POLR1A	POLR1E
Gene Name		polymerase (RNA) I polypeptide A, 194kDa	polymerase (RNA) I polypeptide E, 53kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus DNA-directed RNA Polymerase I Complex Cytoplasm	Nucleus Nucleoplasm Nucleolus DNA-directed RNA Polymerase I Complex
	Molecular Function	RNA Polymerase I Activity DNA Binding Protein Binding Zinc Ion Binding	RNA Polymerase I Activity RNA Polymerase I Transcription Factor Binding DNA Binding
	Biological Process	Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription RRNA Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression	NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ANP32B NFKBIB NOLC1 POLR1E REL RRN3 TCF4	7 interactors: CD3EAP NFKBIB POLR1A POLR1B POLR1C TAF1C UBTF
Entrez ID		25885	64425
HPRD ID		10161	15096
Ensembl ID		ENSG00000068654	ENSG00000137054
Uniprot IDs		O95602 Q9H6T2	Q9GZS1
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleolus Organization Positive Regulation Of Protein Export From Nucleus Protein-DNA Complex Assembly DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase I Promoter Regulation Of Protein Export From Nucleus Transcription From RNA Polymerase I Promoter RNA Metabolic Process Positive Regulation Of Cytokine Production Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Type I Interferon Production Nucleobase-containing Compound Metabolic Process Regulation Of Cytokine Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Nucleocytoplasmic Transport Cellular Nitrogen Compound Metabolic Process Nucleus Organization Regulation Of Cell Death RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Cellular Macromolecular Complex Assembly Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Intracellular Protein Transport Gene Expression Maintenance Of DNA Repeat Elements Innate Immune Response Cellular Macromolecule Biosynthetic Process Ribosome Biogenesis Macromolecule Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Embryonic Genitalia Morphogenesis Positive Regulation Of Intracellular Transport Negative Regulation Of Cell Death Cytoplasm Organization Myoblast Fate Commitment Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Protein Transport Secretory Granule Localization Hindgut Morphogenesis Insulin Metabolic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Cellular Metabolic Process	Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RRNA Transcription Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Type I Interferon Production Nucleologenesis Regulation Of Metabolic Process Regulation Of Type I Interferon Production Nucleolus Organization Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of Cytokine Production Chromatin Silencing At RDNA Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Cytokine Production Chromatin Silencing Transcription From RNA Polymerase III Promoter Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Innate Immune Response
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