POLR1A and POLR1E

Number of citations of the paper that reports this interaction (PubMedID 15226435)
57

Data Source:
HPRD (in vitro)

		POLR1A	POLR1E
Description		RNA polymerase I subunit A	RNA polymerase I subunit E
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Chromatin Nucleus Nucleoplasm Chromosome Nucleolus RNA Polymerase I Complex	DNA-directed RNA Polymerase Complex Fibrillar Center Nucleus Nucleoplasm Nucleolus RNA Polymerase I Complex
	Molecular Function	Magnesium Ion Binding DNA Binding Chromatin Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity 5'-3' RNA Polymerase Activity Metal Ion Binding DNA/RNA Hybrid Binding	RNA Polymerase I General Transcription Initiation Factor Binding DNA Binding Protein Binding
	Biological Process	DNA-templated Transcription Transcription By RNA Polymerase I Nucleolar Large RRNA Transcription By RNA Polymerase I Negative Regulation Of Protein Localization To Nucleolus	RNA Polymerase I Preinitiation Complex Assembly DNA-templated Transcription Transcription Initiation At RNA Polymerase I Promoter Transcription Elongation By RNA Polymerase I Nucleolar Large RRNA Transcription By RNA Polymerase I
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Facial emotion recognition (sad faces) ( 28608620)
Interacting Genes		10 interacting genes: ANP32B DYDC2 MEOX2 NFKBIB NOLC1 POLR1E PTEN RRN3 SKP2 TCF4	9 interacting genes: NFKBIB OGT POLR1A POLR1B POLR1C POLR1G SIRT7 TAF1C UBTF
Entrez ID		25885	64425
HPRD ID		10161	15096
Ensembl ID		ENSG00000068654	ENSG00000137054
Uniprot IDs		O95602	B4E005 Q9GZS1
PDB IDs		7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43	7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43
Enriched GO Terms of Interacting Partners?		Protein-DNA Complex Assembly Nucleolus Organization Transcription Initiation At RNA Polymerase I Promoter RNA Polymerase I Preinitiation Complex Assembly RNA Polymerase Binding Molecular Function Inhibitor Activity Nucleolus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Synaptic Vesicle Clustering Transcription Preinitiation Complex Assembly RNA Polymerase I General Transcription Initiation Factor Binding Positive Regulation Of Macromolecule Metabolic Process Roof Of Mouth Development Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Negative Regulation Of Adaptive Immune Memory Response DNA-templated Transcription Initiation Nucleus Organization Beta-catenin Binding Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Beta-catenin-TCF7L2 Complex RNA Polymerase I Core Binding Positive Regulation Of Metabolic Process	Transcription By RNA Polymerase I DNA-templated Transcription RNA Polymerase I Complex RRNA Transcription Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process DNA-directed RNA Polymerase Complex Transcription Initiation At RNA Polymerase I Promoter Fibrillar Center RNA Metabolic Process Nucleolus DNA-directed RNA Polymerase Activity Nucleic Acid Metabolic Process RNA Polymerase I General Transcription Initiation Factor Activity DNA/RNA Hybrid Binding 5'-3' RNA Polymerase Activity Nucleobase-containing Compound Metabolic Process RRNA Metabolic Process DNA-templated Transcription Initiation RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase I Nucleoplasm Regulation Of Transcription By RNA Polymerase I Regulation Of Gluconeogenesis Chromosome Transcription Preinitiation Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Nucleolus Organizer Region Negative Regulation Of Protein Ubiquitination Nucleus RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Protein Localization To Nucleolus Histone H3K18 Deacetylase Activity, NAD-dependent NAD-dependent Protein-lysine Depropionylase Activity Protein Deglutarylation Protein-succinyllysine Desuccinylase Activity Protein Depropionylation Protein-glutaryllysine Deglutarylase Activity Nucleologenesis Negative Regulation Of Post-translational Protein Modification Nucleotidyltransferase Activity Regulation Of Glucose Metabolic Process Protein O-acetylglucosaminyltransferase Activity RNA Polymerase I Transcription Regulator Complex Ribonucleoside Binding Chromatin Binding Regulation Of Glucose Mediated Signaling Pathway
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