POLR1A and NFKBIB

Number of citations of the paper that reports this interaction (PMID 14743216)
197

Data Source:
HPRD (in vitro)

		POLR1A	NFKBIB
Gene Name		polymerase (RNA) I polypeptide A, 194kDa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus DNA-directed RNA Polymerase I Complex Cytoplasm	Nucleus Cytosol
	Molecular Function	RNA Polymerase I Activity DNA Binding Protein Binding Zinc Ion Binding	Transcription Coactivator Activity Signal Transducer Activity Protein Binding
	Biological Process	Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Gene Expression Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Signal Transduction Positive Regulation Of Type I Interferon Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Lipopolysaccharide
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription RNA Polymerase I Transcription Termination RNA Polymerase I Promoter Escape RNA Polymerase I Promoter Clearance Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression	Signaling by the B Cell Receptor (BCR) Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade RIP-mediated NFkB activation via ZBP1 Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll Like Receptor 10 (TLR10) Cascade Activation of NF-kappaB in B cells Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade TRAF6 mediated NF-kB activation Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: ANP32B NFKBIB NOLC1 POLR1E REL RRN3 TCF4	40 interactors: APP BAK1 BTRC CD3EAP CDC25A CHUK CSNK2A1 CUL1 DNAJA3 ESR2 GIT2 IKBKB IKBKG KPNA2 LRPPRC MCC MTIF2 NCOR2 NFKB1 NFKB2 NFKBIA NGFR NKIRAS1 NKIRAS2 PDCD2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2H POLR2L PPARG RASAL2 REL RELA RXRA SKP1 TSPAN1 VPS52
Entrez ID		25885	4793
HPRD ID		10161	07260
Ensembl ID		ENSG00000068654	ENSG00000104825
Uniprot IDs		O95602 Q9H6T2	Q15653
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleolus Organization Positive Regulation Of Protein Export From Nucleus Protein-DNA Complex Assembly DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase I Promoter Regulation Of Protein Export From Nucleus Transcription From RNA Polymerase I Promoter RNA Metabolic Process Positive Regulation Of Cytokine Production Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Type I Interferon Production Nucleobase-containing Compound Metabolic Process Regulation Of Cytokine Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Nucleocytoplasmic Transport Cellular Nitrogen Compound Metabolic Process Nucleus Organization Regulation Of Cell Death RNA Polymerase I Transcriptional Preinitiation Complex Assembly At The Promoter For The Nuclear Large RRNA Transcript Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Cellular Macromolecular Complex Assembly Transcription Of Nuclear Large RRNA Transcript From RNA Polymerase I Promoter Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Intracellular Protein Transport Gene Expression Maintenance Of DNA Repeat Elements Innate Immune Response Cellular Macromolecule Biosynthetic Process Ribosome Biogenesis Macromolecule Biosynthetic Process Regulation Of Nucleocytoplasmic Transport Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Embryonic Genitalia Morphogenesis Positive Regulation Of Intracellular Transport Negative Regulation Of Cell Death Cytoplasm Organization Myoblast Fate Commitment Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Protein Transport Secretory Granule Localization Hindgut Morphogenesis Insulin Metabolic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of Cellular Metabolic Process	Positive Regulation Of Type I Interferon Production Regulation Of Type I Interferon Production Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter DNA-templated Transcription, Initiation Positive Regulation Of Cytokine Production Regulation Of Metabolic Process Negative Regulation Of Gene Expression I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic DNA-templated Transcription, Elongation Regulation Of Gene Expression Regulation Of Cytokine Production Toll-like Receptor 5 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Intracellular Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Response To Stimulus Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Immune Response Defense Response Regulation Of Innate Immune Response Regulation Of Protein Metabolic Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor Signaling Pathway Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of Gene Expression, Epigenetic Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Activation Of Innate Immune Response
Tagcloud ?			abi analyse ctla4 episodes genotyped ikbkb il4ra il8 map3k1 mbl2 polymorphisms prism recurrent rhinovirus rs1800450ct rs1801275gg rs2146323aa rs2233419ag rs3087243ag rs3136641tt rs3747811at rs3775291tc rs4073at rs702689aa rs833058ct tlr3 vegfa wheezing
Tagcloud (Difference) ?			abi analyse ctla4 episodes genotyped ikbkb il4ra il8 map3k1 mbl2 polymorphisms prism recurrent rhinovirus rs1800450ct rs1801275gg rs2146323aa rs2233419ag rs3087243ag rs3136641tt rs3747811at rs3775291tc rs4073at rs702689aa rs833058ct tlr3 vegfa wheezing
Tagcloud (Intersection) ?