RNF216 and RNF11

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)

		RNF216	RNF11
Description		ring finger protein 216	ring finger protein 11
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Clathrin-coated Vesicle Cytoplasmic Vesicle	Ubiquitin Ligase Complex Nucleus Cytoplasm Endosome Early Endosome Recycling Endosome Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Apoptotic Process Protein Ubiquitination Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination	Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination
Pathways		Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465)	Atrial fibrillation ( 29290336) Male-pattern baldness ( 28196072) QRS duration ( 21076409)
Interacting Genes		33 interacting genes: AGFG1 BRCA1 CAPN15 DYRK1A FAM168A FLNB KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 STAU2 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A	69 interacting genes: AKT1 ANKRD13A ANKRD28 APP ASCC2 AUP1 CALCOCO2 CBLB CCDC127 DCUN1D1 EPN1 EPN2 EPN3 EPS15 ERCC6 FANCL GGA1 GGA2 GGA3 HERC1 HERC2 HUWE1 IKBKG ITCH MYO6 NEDD4 NEDD4L OPTN PDCD6IP POLI PTPRC QARS1 RABGEF1 RIPK1 RNF168 RNF216 RPS27A SDCBP SMURF1 SMURF2 SNRNP70 SPRTN STAM2 STAMBP TAX1BP1 TNFAIP3 TNIP1 TOM1L2 UBA52 UBAC1 UBB UBC UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBQLN2 UBQLN4 USP5 WWP1 WWP2 YAP1 ZFYVE16 ZFYVE9 ZNF350
Entrez ID		54476	26994
HPRD ID		15550	09955
Ensembl ID		ENSG00000011275	ENSG00000123091
Uniprot IDs		A8K8N1 Q9NWF9	Q9Y3C5
PDB IDs		7M4M 7M4N 7M4O 8EB0
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Metabolic Process Positive Regulation Of Defense Response Proteolysis Proteolysis Involved In Protein Catabolic Process Toll-like Receptor Signaling Pathway Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-8 Production Regulation Of Cytokine Production Macromolecule Catabolic Process Regulation Of Interleukin-8 Production Pattern Recognition Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Immune Response-regulating Signaling Pathway Endosome Membrane Innate Immune Response-activating Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Regulation Of Dendritic Cell Cytokine Production Regulation Of Type I Interferon Production Regulation Of Immune Response Protein Autoubiquitination Positive Regulation Of Metabolic Process Activation Of Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Protein K6-linked Ubiquitination Response To Stress Positive Regulation Of Interferon-alpha Production Protein K48-linked Deubiquitination Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process	Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Macromolecule Catabolic Process Protein Polyubiquitination Proteolysis Ubiquitin Binding Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Activity Cytosol Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Monoubiquitination Endosome Ubiquitin Ligase Complex Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Negative Regulation Of Signal Transduction Positive Regulation Of Catabolic Process Protein K63-linked Ubiquitination Positive Regulation Of Protein Catabolic Process K63-linked Polyubiquitin Modification-dependent Protein Binding Transferase Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Negative Regulation Of Canonical NF-kappaB Signal Transduction Early Endosome Membrane Positive Regulation Of Protein Modification Process Autophagosome Protein-containing Complex Positive Regulation Of Post-translational Protein Modification DNA Damage Response Regulation Of Protein Ubiquitination Cytoplasm Cellular Response To Stress Extracellular Exosome
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