RNF216 and CAPN15

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RNF216	CAPN15
Description		ring finger protein 216	calpain 15
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Clathrin-coated Vesicle Cytoplasmic Vesicle	Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Apoptotic Process Protein Ubiquitination Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination	Proteolysis
Pathways		Negative regulators of DDX58/IFIH1 signaling	Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		33 interacting genes: AGFG1 BRCA1 CAPN15 DYRK1A FAM168A FLNB KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 STAU2 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A	7 interacting genes: CPEB2 DAZAP2 RNF216 RNF26 SOX4 TRAF2 UBC
Entrez ID		54476	6650
HPRD ID		15550	07220
Ensembl ID		ENSG00000011275	ENSG00000103326
Uniprot IDs		A8K8N1 Q9NWF9	O75808
PDB IDs		7M4M 7M4N 7M4O 8EB0
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Metabolic Process Positive Regulation Of Defense Response Proteolysis Proteolysis Involved In Protein Catabolic Process Toll-like Receptor Signaling Pathway Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-8 Production Regulation Of Cytokine Production Macromolecule Catabolic Process Regulation Of Interleukin-8 Production Pattern Recognition Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Immune Response-regulating Signaling Pathway Endosome Membrane Innate Immune Response-activating Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Regulation Of Dendritic Cell Cytokine Production Regulation Of Type I Interferon Production Regulation Of Immune Response Protein Autoubiquitination Positive Regulation Of Metabolic Process Activation Of Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Protein K6-linked Ubiquitination Response To Stress Positive Regulation Of Interferon-alpha Production Protein K48-linked Deubiquitination Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process	Mitogen-activated Protein Kinase Kinase Kinase Binding Post-translational Protein Modification Protein Polyubiquitination Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin Protein Ligase Activity Regulation Of Defense Response To Virus Macromolecule Catabolic Process TORC2 Complex Disassembly Negative Regulation Of Cytoplasmic Translational Elongation TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Modification-dependent Protein Catabolic Process Regulation Of Type I Interferon Production Ascending Aorta Morphogenesis Pro-B Cell Differentiation Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Atrial Septum Primum Morphogenesis Regulation Of Gene Expression Protein Modification Process CD27 Signaling Pathway Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Translational Elongation Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Noradrenergic Neuron Differentiation Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Mitral Valve Morphogenesis Regulation Of Cytokine Production Protein Localization To Perinuclear Region Of Cytoplasm Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Gamma-delta T Cell Activation Cellular Response To Oxygen-containing Compound Regulation Of Gamma-delta T Cell Differentiation Thioesterase Binding CD40 Receptor Complex CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Interleukin-17-mediated Signaling Pathway Catabolic Process Negative Regulation Of Cytoplasmic Translation Regulation Of Translational Elongation Lymphoid Progenitor Cell Differentiation Positive Regulation Of JUN Kinase Activity
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