RNF216 and STAU2

Number of citations of the paper that reports this interaction (PubMedID 37439148)
0

Data Source:
BioGRID (pull down)

		RNF216	STAU2
Description		ring finger protein 216	staufen double-stranded RNA binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Clathrin-coated Vesicle Cytoplasmic Vesicle	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Microtubule Plasma Membrane Cytoplasmic Stress Granule Membrane Axon Dendrite Nuclear Membrane Dendrite Cytoplasm Protein-containing Complex Neuron Projection Neuronal Cell Body Dendritic Shaft Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Double-stranded RNA Binding MRNA Binding Protein Binding Kinesin Binding Hsp70 Protein Binding Ribosome Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Apoptotic Process Protein Ubiquitination Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination	Germ Cell Development Intracellular MRNA Localization Regulation Of Actin Cytoskeleton Organization Cellular Response To Oxidative Stress Protein Localization To Synapse Eye Morphogenesis Regulation Of Filopodium Assembly Positive Regulation Of Synapse Assembly Positive Regulation Of Dendritic Spine Morphogenesis Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Positive Regulation Of Long-term Synaptic Depression
Pathways		Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465)	A body shape index ( 34021172) Alzheimer's disease (late onset) ( 30820047) Axial length ( 24144296) Malaria ( 31844061) Pelvic organ prolapse (moderate/severe) ( 26545240) Refractive error ( 32231278) Urate levels in obese individuals ( 25811787) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		33 interacting genes: AGFG1 BRCA1 CAPN15 DYRK1A FAM168A FLNB KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 STAU2 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A	6 interacting genes: CEP126 DHX58 FOXP1 LINC00624 OGT RNF216
Entrez ID		54476	27067
HPRD ID		15550	09328
Ensembl ID		ENSG00000011275	ENSG00000040341
Uniprot IDs		A8K8N1 Q9NWF9	A8K276 Q9NUL3
PDB IDs		7M4M 7M4N 7M4O 8EB0
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Metabolic Process Positive Regulation Of Defense Response Proteolysis Proteolysis Involved In Protein Catabolic Process Toll-like Receptor Signaling Pathway Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-8 Production Regulation Of Cytokine Production Macromolecule Catabolic Process Regulation Of Interleukin-8 Production Pattern Recognition Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Immune Response-regulating Signaling Pathway Endosome Membrane Innate Immune Response-activating Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Regulation Of Dendritic Cell Cytokine Production Regulation Of Type I Interferon Production Regulation Of Immune Response Protein Autoubiquitination Positive Regulation Of Metabolic Process Activation Of Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Protein K6-linked Ubiquitination Response To Stress Positive Regulation Of Interferon-alpha Production Protein K48-linked Deubiquitination Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process	Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Gene Expression Negative Regulation Of Type I Interferon Production Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Hemopoiesis Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Interleukin-21 Production Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Osteoclast Development Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Endothelial Tube Morphogenesis Regulation Of Type I Interferon Production Positive Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Negative Regulation Of MDA-5 Signaling Pathway Positive Regulation Of B Cell Receptor Signaling Pathway
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