RNF216 and TLR5

Number of citations of the paper that reports this interaction (PubMedID 15107846)
0

Data Source:
HPRD (two hybrid)

		RNF216	TLR5
Description		ring finger protein 216	toll like receptor 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Clathrin-coated Vesicle Cytoplasmic Vesicle	Plasma Membrane Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding Protein Binding Signaling Receptor Activity Pattern Recognition Receptor Activity
	Biological Process	Apoptotic Process Protein Ubiquitination Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination	Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Immune Response Signal Transduction Male Gonad Development Positive Regulation Of Interleukin-8 Production Toll-like Receptor 5 Signaling Pathway Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus
Pathways		Negative regulators of DDX58/IFIH1 signaling	Toll Like Receptor 5 (TLR5) Cascade MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) MyD88 cascade initiated on plasma membrane
Drugs
Diseases			Systemic lupus erythematosus
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465)	Monocyte percentage of white cells ( 32888494)
Interacting Genes		33 interacting genes: AGFG1 BRCA1 CAPN15 DYRK1A FAM168A FLNB KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 STAU2 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A	5 interacting genes: MYD88 RNF216 SIGIRR TLR1 TLR4
Entrez ID		54476	7100
HPRD ID		15550	04326
Ensembl ID		ENSG00000011275	ENSG00000187554
Uniprot IDs		A8K8N1 Q9NWF9	A0A2R8Y7Z4 O60602
PDB IDs		7M4M 7M4N 7M4O 8EB0	3J0A 8AR2
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Metabolic Process Positive Regulation Of Defense Response Proteolysis Proteolysis Involved In Protein Catabolic Process Toll-like Receptor Signaling Pathway Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-8 Production Regulation Of Cytokine Production Macromolecule Catabolic Process Regulation Of Interleukin-8 Production Pattern Recognition Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Immune Response-regulating Signaling Pathway Endosome Membrane Innate Immune Response-activating Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Regulation Of Dendritic Cell Cytokine Production Regulation Of Type I Interferon Production Regulation Of Immune Response Protein Autoubiquitination Positive Regulation Of Metabolic Process Activation Of Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Protein K6-linked Ubiquitination Response To Stress Positive Regulation Of Interferon-alpha Production Protein K48-linked Deubiquitination Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process	Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway Positive Regulation Of Interleukin-8 Production Regulation Of Chemokine Production Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-6 Production Microglia Differentiation Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Interleukin-23 Production Myeloid Leukocyte Activation Regulation Of Type I Interferon Production Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Inflammatory Response Detection Of Molecule Of Bacterial Origin Regulation Of Interleukin-6 Production NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating MyD88-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Activation Of Innate Immune Response Positive Regulation Of Macrophage Cytokine Production Regulation Of Defense Response Cellular Response To Low-density Lipoprotein Particle Stimulus Detection Of Biotic Stimulus Positive Regulation Of NLRP3 Inflammasome Complex Assembly Leukocyte Activation Involved In Inflammatory Response Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Cellular Response To Lipoprotein Particle Stimulus Regulation Of Macrophage Cytokine Production Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Macrophage Differentiation Response To Molecule Of Bacterial Origin Cell Surface Toll-like Receptor Signaling Pathway Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of Interferon-beta Production JNK Cascade Positive Regulation Of Interleukin-1 Beta Production Immune Response-regulating Signaling Pathway
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