RNF216 and TLR5

Number of citations of the paper that reports this interaction (PMID 15107846)
62

Data Source:
HPRD (two hybrid)

		RNF216	TLR5
Gene Name		ring finger protein 216	toll-like receptor 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Ligase Activity	Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Binding
	Biological Process	Apoptotic Process Viral Process Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Male Gonad Development Positive Regulation Of Interleukin-8 Production Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Defense Response To Bacterium Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cytokine Secretion Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus
Pathways			Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: AGFG1 BRCA1 KIR2DL4 RIPK1 RNF11 TLR3 TLR4 TLR5 TLR9 UBE2L3 UBE2L6	5 interactors: MYD88 RNF216 SIGIRR TLR1 TLR4
Entrez ID		54476	7100
HPRD ID		15550	04326
Ensembl ID		ENSG00000011275	ENSG00000187554
Uniprot IDs		A8K8N1 Q9NWF9	O60602
PDB IDs			1P95 3J0A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interleukin-8 Production Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Innate Immune Response Positive Regulation Of Toll-like Receptor Signaling Pathway I-kappaB Phosphorylation Positive Regulation Of Type I Interferon Production Regulation Of Innate Immune Response Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Interferon-beta Production Cellular Response To Organic Substance Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Defense Response Regulation Of Reactive Oxygen Species Metabolic Process Innate Immune Response Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of JNK Cascade Regulation Of Interferon-beta Production Regulation Of Toll-like Receptor Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Chemokine Production Regulation Of Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interferon-alpha Biosynthetic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Stress-activated MAPK Cascade Defense Response To Bacterium Positive Regulation Of Interferon-gamma Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Chemokine Production Response To Organic Substance I-kappaB Kinase/NF-kappaB Signaling Necroptotic Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Transferase Activity	Regulation Of Cytokine Biosynthetic Process Regulation Of Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Cytokine Biosynthetic Process MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Regulation Of Tumor Necrosis Factor Production Regulation Of Interleukin-6 Production Toll-like Receptor Signaling Pathway Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Activation Of Innate Immune Response Detection Of Molecule Of Bacterial Origin Cellular Response To Molecule Of Bacterial Origin Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Detection Of Biotic Stimulus Macrophage Activation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Lipopolysaccharide-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Response To Fungus Regulation Of Interferon-beta Production Positive Regulation Of Chemokine Production Positive Regulation Of Cytokine Production Regulation Of Immune System Process Defense Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Immune Response-regulating Signaling Pathway Response To Bacterium Cellular Response To Mechanical Stimulus Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Immune Response Toll-like Receptor 1 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Detection Of Fungus Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Response To Other Organism Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Biotic Stimulus
Tagcloud ?		amplified analyze cadherin cdh1 cellularity chromosomal deadliest diffuse disrupt driver ec1 exomes exonic gastric genomes instability insufficient intestinal junction notoriously oncogenes perturbations somatic stomach suppressive suppressors thorough tsc2 variations	adjuvanted alum anticocaine antihapten avenue benchmark boosting c4 cocaine conjugates exploration flagellin flic gne hampered hapten immunogenicity impacting inadequate indirectly klh liposomal lives millions mpla nlrc4 problematic reasoning tactics
Tagcloud (Difference) ?		amplified analyze cadherin cdh1 cellularity chromosomal deadliest diffuse disrupt driver ec1 exomes exonic gastric genomes instability insufficient intestinal junction notoriously oncogenes perturbations somatic stomach suppressive suppressors thorough tsc2 variations	adjuvanted alum anticocaine antihapten avenue benchmark boosting c4 cocaine conjugates exploration flagellin flic gne hampered hapten immunogenicity impacting inadequate indirectly klh liposomal lives millions mpla nlrc4 problematic reasoning tactics
Tagcloud (Intersection) ?