RNF216 and KIR2DL4

Number of citations of the paper that reports this interaction (PMID 21270397)
8

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		RNF216	KIR2DL4
Gene Name		ring finger protein 216	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Ligase Activity	Transmembrane Signaling Receptor Activity Protein Binding
	Biological Process	Apoptotic Process Viral Process Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination	Cellular Defense Response Signal Transduction Regulation Of Immune Response
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: AGFG1 BRCA1 KIR2DL4 RIPK1 RNF11 TLR3 TLR4 TLR5 TLR9 UBE2L3 UBE2L6	5 interactors: FCER1G HLA-G RBPMS RNF216 TRIP6
Entrez ID		54476	3805
HPRD ID		15550	16082
Ensembl ID		ENSG00000011275	ENSG00000189013
Uniprot IDs		A8K8N1 Q9NWF9	Q99706
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interleukin-8 Production Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Innate Immune Response Positive Regulation Of Toll-like Receptor Signaling Pathway I-kappaB Phosphorylation Positive Regulation Of Type I Interferon Production Regulation Of Innate Immune Response Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Interferon-beta Production Cellular Response To Organic Substance Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Defense Response Regulation Of Reactive Oxygen Species Metabolic Process Innate Immune Response Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of JNK Cascade Regulation Of Interferon-beta Production Regulation Of Toll-like Receptor Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Chemokine Production Regulation Of Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interferon-alpha Biosynthetic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Stress-activated MAPK Cascade Defense Response To Bacterium Positive Regulation Of Interferon-gamma Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Chemokine Production Response To Organic Substance I-kappaB Kinase/NF-kappaB Signaling Necroptotic Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Transferase Activity	Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Regulation Of Cytokine Production Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Type III Hypersensitivity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Transport Positive Regulation Of Adaptive Immune Response Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Type I Hypersensitivity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Serotonin Secretion By Platelet Positive Regulation Of Type IIa Hypersensitivity Regulation Of Adaptive Immune Response Regulation Of Protein Localization To Nucleus Regulation Of Cellular Localization Regulation Of Nucleocytoplasmic Transport Antigen Processing And Presentation Of Peptide Antigen Serotonin Secretion Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Regulatory T Cell Differentiation Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Protein Transport Negative Regulation Of Mast Cell Apoptotic Process Negative Regulation Of Dendritic Cell Differentiation Immune Response-inhibiting Signal Transduction Antigen Processing And Presentation Regulation Of Immune System Process Regulation Of Mast Cell Apoptotic Process Serotonin Transport Positive Regulation Of Hypersensitivity Positive Regulation Of Cell Activation Regulation Of Dendritic Cell Differentiation Neutrophil Activation Involved In Immune Response Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune System Process Positive Regulation Of T Cell Tolerance Induction Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Inflammatory Response To Antigenic Stimulus Phagocytosis, Engulfment Positive Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Mast Cell Activation Regulation Of SMAD Protein Import Into Nucleus
Tagcloud ?		amplified analyze cadherin cdh1 cellularity chromosomal deadliest diffuse disrupt driver ec1 exomes exonic gastric genomes instability insufficient intestinal junction notoriously oncogenes perturbations somatic stomach suppressive suppressors thorough tsc2 variations	accessible cd28 cd4 competency conferred demethylated demethylation di dimethylated dimethylation dnmt hut78 ig inactive indicative jurkat killer kirs lys methyltransferase modifications mostly nk partially strikingly susceptible transcribe trimethylated
Tagcloud (Difference) ?		amplified analyze cadherin cdh1 cellularity chromosomal deadliest diffuse disrupt driver ec1 exomes exonic gastric genomes instability insufficient intestinal junction notoriously oncogenes perturbations somatic stomach suppressive suppressors thorough tsc2 variations	accessible cd28 cd4 competency conferred demethylated demethylation di dimethylated dimethylation dnmt hut78 ig inactive indicative jurkat killer kirs lys methyltransferase modifications mostly nk partially strikingly susceptible transcribe trimethylated
Tagcloud (Intersection) ?