RNF216 and KIR2DL4

Number of citations of the paper that reports this interaction (PubMedID 21270397)
40

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		RNF216	KIR2DL4
Description		ring finger protein 216	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Clathrin-coated Vesicle Cytoplasmic Vesicle	Endosome Plasma Membrane Membrane Early Endosome Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Transmembrane Signaling Receptor Activity Protein Binding MHC Class Ib Receptor Activity
	Biological Process	Apoptotic Process Protein Ubiquitination Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination	Positive Regulation Of Natural Killer Cell Cytokine Production Immune Response-regulating Signaling Pathway Cellular Defense Response Signal Transduction Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cellular Senescence
Pathways		Negative regulators of DDX58/IFIH1 signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Heel bone mineral density x serum urate levels interaction ( 34046847) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465)	Objective response to lithium treatment ( 26503763)
Interacting Genes		33 interacting genes: AGFG1 BRCA1 CAPN15 DYRK1A FAM168A FLNB KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 STAU2 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A	9 interacting genes: BPIFA1 FCER1G FHL5 HLA-G INCA1 RBPMS RNF216 TIMMDC1 TRIP6
Entrez ID		54476	3805
HPRD ID		15550	16082
Ensembl ID		ENSG00000011275	ENSG00000189013
Uniprot IDs		A8K8N1 Q9NWF9	A0A0B4J1S6 A0A376A929 Q99706
PDB IDs		7M4M 7M4N 7M4O 8EB0	3WYR
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Modification Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-protein Transferase Activity Protein Metabolic Process Positive Regulation Of Defense Response Proteolysis Proteolysis Involved In Protein Catabolic Process Toll-like Receptor Signaling Pathway Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-8 Production Regulation Of Cytokine Production Macromolecule Catabolic Process Regulation Of Interleukin-8 Production Pattern Recognition Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Immune Response-regulating Signaling Pathway Endosome Membrane Innate Immune Response-activating Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Immune Response-activating Signaling Pathway Regulation Of Dendritic Cell Cytokine Production Regulation Of Type I Interferon Production Regulation Of Immune Response Protein Autoubiquitination Positive Regulation Of Metabolic Process Activation Of Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Protein K6-linked Ubiquitination Response To Stress Positive Regulation Of Interferon-alpha Production Protein K48-linked Deubiquitination Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process	Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Type I Hypersensitivity Antigen Processing And Presentation Mast Cell Apoptotic Process Serotonin Secretion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Cytokine Production Involved In Immune Response B Cell Mediated Immunity Negative Regulation Of Mast Cell Apoptotic Process IgE Receptor Activity Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Serotonin Secretion By Platelet Regulation Of Cytokine Production Involved In Immune Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Positive Regulation Of Lymphocyte Mediated Immunity Lymphocyte Mediated Immunity Fc-gamma Receptor III Complex Positive Regulation Of Adaptive Immune Response Fc-epsilon Receptor I Complex Positive Regulation Of Type III Hypersensitivity CD8 Receptor Binding Tolerance Induction Dependent Upon Immune Response Peripheral B Cell Tolerance Induction MRNA CDS Binding Immune Response In Nasopharyngeal-associated Lymphoid Tissue Immune Response In Gut-associated Lymphoid Tissue Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Leukocyte Mediated Immunity Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Protection From Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Negative Regulation Of G0 To G1 Transition Negative Regulation Of Dendritic Cell Differentiation Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Mast Cell Activation
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