RNF216 and RIPK1

Number of citations of the paper that reports this interaction (PMID 11854271)
6

Data Source:
HPRD (two hybrid, in vivo)

		RNF216	RIPK1
Gene Name		ring finger protein 216	receptor (TNFRSF)-interacting serine-threonine kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Cytoplasm Mitochondrion Cytosol Death-inducing Signaling Complex Receptor Complex Membrane Raft Ripoptosome
	Molecular Function	Protein Binding Zinc Ion Binding Ligase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Death Receptor Binding Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Identical Protein Binding Death Domain Binding
	Biological Process	Apoptotic Process Viral Process Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination	Positive Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of JUN Kinase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Tumor Necrosis Factor TRIF-dependent Toll-like Receptor Signaling Pathway Peptidyl-serine Autophosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Catabolic Process Innate Immune Response Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Protein Heterooligomerization Positive Regulation Of Necroptotic Process T Cell Apoptotic Process Necroptotic Process Regulation Of ATP:ADP Antiporter Activity Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Ripoptosome Assembly Necroptotic Signaling Pathway Ripoptosome Assembly Involved In Necroptotic Process Amyloid Fibril Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Regulation by c-FLIP Caspase-8 activation by cleavage Dimerization of procaspase-8 IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA MyD88-independent cascade RIP-mediated NFkB activation via ZBP1 Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades ZBP1(DAI) mediated induction of type I IFNs Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Programmed Cell Death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 TRIF-mediated programmed cell death Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: AGFG1 BRCA1 KIR2DL4 RIPK1 RNF11 TLR3 TLR4 TLR5 TLR9 UBE2L3 UBE2L6	45 interactors: BIRC2 BIRC3 CASP8 CCDC50 CDC42BPB CFLAR CRADD EGFR FADD FAS HSP90AA1 IKBKB IKBKG ITCH MAP3K14 MAP3K3 MAP3K8 NFKB1 NUMBL OTUD1 PELI1 PTK2 RIPK3 RNF11 RNF216 SQSTM1 TAX1BP1 TICAM1 TNF TNFAIP3 TNFRSF10A TNFRSF10B TNFRSF1A TRADD TRAF1 TRAF2 TRAF3 TRAF5 TRIM38 TRPC4AP UBE2N USP2 XIAP YOD1 ZFAND5
Entrez ID		54476	8737
HPRD ID		15550	04583
Ensembl ID		ENSG00000011275	ENSG00000137275
Uniprot IDs		A8K8N1 Q9NWF9	Q13546
PDB IDs			4ITH 4ITI 4ITJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Interleukin-8 Production Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Innate Immune Response Positive Regulation Of Toll-like Receptor Signaling Pathway I-kappaB Phosphorylation Positive Regulation Of Type I Interferon Production Regulation Of Innate Immune Response Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Interferon-beta Production Cellular Response To Organic Substance Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Defense Response Regulation Of Reactive Oxygen Species Metabolic Process Innate Immune Response Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of JNK Cascade Regulation Of Interferon-beta Production Regulation Of Toll-like Receptor Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Positive Regulation Of Chemokine Production Regulation Of Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interferon-alpha Biosynthetic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Stress-activated MAPK Cascade Defense Response To Bacterium Positive Regulation Of Interferon-gamma Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Chemokine Production Response To Organic Substance I-kappaB Kinase/NF-kappaB Signaling Necroptotic Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Transferase Activity	Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity Immune Response-regulating Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Signaling MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Protein Metabolic Process Innate Immune Response Positive Regulation Of Cellular Metabolic Process Signal Transduction Immune Response NIK/NF-kappaB Signaling Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signaling Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Type I Interferon Production Cellular Response To Mechanical Stimulus Cell Communication Defense Response Positive Regulation Of Protein Modification Process
Tagcloud ?		amplified analyze cadherin cdh1 cellularity chromosomal deadliest diffuse disrupt driver ec1 exomes exonic gastric genomes instability insufficient intestinal junction notoriously oncogenes perturbations somatic stomach suppressive suppressors thorough tsc2 variations	allowed autocrine back deficient endoplasmic er instead interacting intrinsic kills l929 lineage lymphotoxin mlkl necroptosis necrosis opportunities pathologies protect remarkably repression rescue reticulum ripk3 stress stressors switch tnfr1 unresolved
Tagcloud (Difference) ?		amplified analyze cadherin cdh1 cellularity chromosomal deadliest diffuse disrupt driver ec1 exomes exonic gastric genomes instability insufficient intestinal junction notoriously oncogenes perturbations somatic stomach suppressive suppressors thorough tsc2 variations	allowed autocrine back deficient endoplasmic er instead interacting intrinsic kills l929 lineage lymphotoxin mlkl necroptosis necrosis opportunities pathologies protect remarkably repression rescue reticulum ripk3 stress stressors switch tnfr1 unresolved
Tagcloud (Intersection) ?