TOLLIP and RNF26

Number of citations of the paper that reports this interaction (PubMedID 37519262)
92

Data Source:
BioGRID (pull down)

		TOLLIP	RNF26
Description		toll interacting protein	ring finger protein 26
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endosome Early Endosome Cytosol Nuclear Body Extrinsic Component Of Plasma Membrane Protein-containing Complex Azurophil Granule Lumen Specific Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Interleukin-1, Type I Receptor Binding Protein Binding Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding SUMO Binding Toll-like Receptor Binding Ubiquitin Binding Molecular Adaptor Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immune System Process Ubiquitin-dependent Protein Catabolic Process Autophagy Inflammatory Response Signal Transduction Phosphorylation Epithelial Cell Differentiation Positive Regulation Of Protein Sumoylation Protein Localization To Endosome Innate Immune Response Leukocyte Activation Interleukin-1-mediated Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Endosome Organization Protein Ubiquitination Regulation Of Type I Interferon Production Negative Regulation Of Defense Response To Virus Protein K11-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm
Pathways		Neutrophil degranulation Interleukin-1 signaling
Drugs
Diseases
GWAS		Gout ( 32238385) Idiopathic pulmonary fibrosis ( 24429156)	Platelet count ( 32888494) Refractive error ( 32231278)
Interacting Genes		78 interacting genes: ACTMAP ACTN2 ARRDC3 ATXN1 BHLHE40 CDIP1 CHD6 CIMIP2B CPSF6 CSN1S1 CSN2 DAB1 DAZAP2 DCDC2 DDIT4L DZIP3 FAM168A FTH1 GGA1 GGA2 GGA3 GUCD1 HERPUD1 IL1R1 IL1RAP IRAK1 IRAK2 KRTAP13-3 KRTAP15-1 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP7-1 LDB1 MEDAG MSS51 MSX2 MVP N4BP2 NEDD8 NRF1 NTAQ1 ODAM PEG10 PHAF1 PRPF39 PRR20A PRR20B PRR20C PRR20D PRR20E PSMB1 RBFOX1 RBFOX2 RBPMS RHOXF2 RNF167 RNF26 RSPH1 RUNX1 SEPTIN1 SETDB1 SIAH1 STN1 TBX3 TENT5A TLR2 TLR4 TOM1 TOM1L1 TTC9C USP54 WBP2 WRNIP1 XRN2 ZBTB16 ZHX1 ZMYND19	54 interacting genes: ASCC3 CAPN15 CBR1 CCDC50 CTNND1 DDB1 DNAJC13 DOCK7 EEF1G EPS15 GMPS GSR GSTP1 HNRNPF HNRNPK HRNR HSPA5 HSPA8 HSPA9 IMMT INCA1 KEAP1 KRT1 KRT10 KRT2 KRT5 KRT6C MAP7D2 MYO6 PARP10 PRSS1 RBCK1 RCC2 RNF31 RPS27A SHARPIN SLC25A5 SQSTM1 TAX1BP1 TOLLIP TOM1L2 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2Q1 UBE2U UBE2W USP15 WRNIP1 YME1L1
Entrez ID		54472	79102
HPRD ID		05887	05842
Ensembl ID		ENSG00000078902	ENSG00000173456
Uniprot IDs		B3KR28 E9PNS3 F2Z2Y8 Q6FIE9 Q8N8J5 Q9H0E2	Q9BY78
PDB IDs		1WGL 2N31
Enriched GO Terms of Interacting Partners?		NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Interleukin-1-mediated Signaling Pathway Endosome Membrane Ubiquitin Binding Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Golgi To Plasma Membrane Protein Transport Lipopolysaccharide-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Matrix Metallopeptidase Secretion Protein Binding Toll-like Receptor Signaling Pathway Intermediate Filament Cell Surface Pattern Recognition Receptor Signaling Pathway Establishment Of Protein Localization To Plasma Membrane Phosphatidylinositol Binding Golgi To Plasma Membrane Transport Interleukin-1 Receptor Activity Toll-like Receptor 2 Signaling Pathway Embryonic Hindlimb Morphogenesis Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Protein Localization To Cell Surface LIM Domain Binding Toll Signaling Pathway Lipopolysaccharide Immune Receptor Activity Interleukin-33-mediated Signaling Pathway Hindlimb Morphogenesis Forelimb Morphogenesis Identical Protein Binding	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Extracellular Exosome Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Catabolic Process Ubiquitin Binding Keratinization LUBAC Complex Cytosol Macromolecule Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Nucleotide Binding ATP Binding Protein Linear Polyubiquitination Structural Constituent Of Skin Epidermis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Organization Protein-macromolecule Adaptor Activity Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoplasm Peptide Cross-linking Protein Monoubiquitination Cornified Envelope Cellular Response To Interleukin-4 Regulation Of Canonical NF-kappaB Signal Transduction K63-linked Polyubiquitin Modification-dependent Protein Binding Protein Refolding Cellular Response To Stress Epidermis Development Response To Interleukin-4 Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Autophagosome Response To Stress Negative Regulation Of Fibroblast Proliferation
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