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TOLLIP and IL1R1
Number of citations of the paper that reports this interaction (PubMedID
17113392
)
0
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(in vivo)
TOLLIP
IL1R1
Description
toll interacting protein
interleukin 1 receptor type 1
Image
GO Annotations
Cellular Component
Extracellular Region
Cytoplasm
Endosome
Early Endosome
Cytosol
Nuclear Body
Extrinsic Component Of Plasma Membrane
Protein-containing Complex
Azurophil Granule Lumen
Specific Granule Lumen
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Extracellular Region
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Molecular Function
Interleukin-1, Type I Receptor Binding
Protein Binding
Kinase Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Binding
SUMO Binding
Toll-like Receptor Binding
Ubiquitin Binding
Molecular Adaptor Activity
Protease Binding
Transmembrane Signaling Receptor Activity
Cytokine Receptor Activity
Interleukin-1 Receptor Activity
Interleukin-1, Type I, Activating Receptor Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Hydrolase Activity
Interleukin-1 Binding
NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
Biological Process
Immune System Process
Ubiquitin-dependent Protein Catabolic Process
Autophagy
Inflammatory Response
Signal Transduction
Phosphorylation
Epithelial Cell Differentiation
Positive Regulation Of Protein Sumoylation
Protein Localization To Endosome
Innate Immune Response
Leukocyte Activation
Interleukin-1-mediated Signaling Pathway
Inflammatory Response
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Smooth Muscle Adaptation
Cytokine-mediated Signaling Pathway
Positive Regulation Of Type II Interferon Production
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Inflammatory Response
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Positive Regulation Of Neutrophil Extravasation
Positive Regulation Of T-helper 1 Cell Cytokine Production
Positive Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways
Neutrophil degranulation
Interleukin-1 signaling
Interleukin-10 signaling
Interleukin-1 signaling
Potential therapeutics for SARS
Drugs
Anakinra
SD118
OMS-103HP
Foreskin fibroblast (neonatal)
Diseases
GWAS
Gout (
32238385
)
Idiopathic pulmonary fibrosis (
24429156
)
Acute anterior uveitis (with or without ankylosing spondylitis) (
25200001
)
Alanine aminotransferase levels (
33547301
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Ankylosing spondylitis (
23749187
)
Asthma (
31959851
31619474
29785011
30929738
22561531
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Blood protein levels (
30072576
)
C-reactive protein levels (
30388399
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
)
Fibrinogen (
23969696
)
Fibrinogen levels (
28107422
26561523
)
Inflammatory bowel disease (
28067908
23128233
)
Primary biliary cholangitis (
26394269
)
Serum protein levels (sST2) (
23999434
)
Very long-chain saturated fatty acid levels (fatty acid 20:0) (
25378659
)
Interacting Genes
78 interacting genes:
ACTMAP
ACTN2
ARRDC3
ATXN1
BHLHE40
CDIP1
CHD6
CIMIP2B
CPSF6
CSN1S1
CSN2
DAB1
DAZAP2
DCDC2
DDIT4L
DZIP3
FAM168A
FTH1
GGA1
GGA2
GGA3
GUCD1
HERPUD1
IL1R1
IL1RAP
IRAK1
IRAK2
KRTAP13-3
KRTAP15-1
KRTAP19-7
KRTAP6-1
KRTAP6-2
KRTAP7-1
LDB1
MEDAG
MSS51
MSX2
MVP
N4BP2
NEDD8
NRF1
NTAQ1
ODAM
PEG10
PHAF1
PRPF39
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMB1
RBFOX1
RBFOX2
RBPMS
RHOXF2
RNF167
RNF26
RSPH1
RUNX1
SEPTIN1
SETDB1
SIAH1
STN1
TBX3
TENT5A
TLR2
TLR4
TOM1
TOM1L1
TTC9C
USP54
WBP2
WRNIP1
XRN2
ZBTB16
ZHX1
ZMYND19
11 interacting genes:
IL1A
IL1B
IL1F10
IL1RAP
IL1RN
IRAK2
MYD88
PIK3R1
SIGIRR
TICAM2
TOLLIP
Entrez ID
54472
3554
HPRD ID
05887
00994
Ensembl ID
ENSG00000078902
ENSG00000115594
Uniprot IDs
B3KR28
E9PNS3
F2Z2Y8
Q6FIE9
Q8N8J5
Q9H0E2
B8ZZW4
P14778
PDB IDs
1WGL
2N31
1G0Y
1IRA
1ITB
4DEP
4GAF
Enriched GO Terms of Interacting Partners
?
NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
Interleukin-1-mediated Signaling Pathway
Endosome Membrane
Ubiquitin Binding
Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus
Golgi To Plasma Membrane Protein Transport
Lipopolysaccharide-mediated Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Cell Surface Toll-like Receptor Signaling Pathway
Positive Regulation Of Matrix Metallopeptidase Secretion
Protein Binding
Toll-like Receptor Signaling Pathway
Intermediate Filament
Cell Surface Pattern Recognition Receptor Signaling Pathway
Establishment Of Protein Localization To Plasma Membrane
Phosphatidylinositol Binding
Golgi To Plasma Membrane Transport
Interleukin-1 Receptor Activity
Toll-like Receptor 2 Signaling Pathway
Embryonic Hindlimb Morphogenesis
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Protein Localization To Cell Surface
LIM Domain Binding
Toll Signaling Pathway
Lipopolysaccharide Immune Receptor Activity
Interleukin-33-mediated Signaling Pathway
Hindlimb Morphogenesis
Forelimb Morphogenesis
Identical Protein Binding
Interleukin-1 Receptor Binding
Inflammatory Response
Interleukin-1-mediated Signaling Pathway
Defense Response
Cytokine-mediated Signaling Pathway
Response To Stress
Immune Response
Acute-phase Response
Immune System Process
Cell Surface Receptor Signaling Pathway
Cellular Response To Lipopolysaccharide
Acute Inflammatory Response
Cellular Response To Molecule Of Bacterial Origin
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Cytokine Production
Response To External Biotic Stimulus
Positive Regulation Of Interleukin-6 Production
Interleukin-1, Type I Receptor Binding
Positive Regulation Of Cytokine Production
Regulation Of Chemokine Production
Response To Lipopolysaccharide
Fever Generation
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Toll-like Receptor 4 Signaling Pathway
Response To Molecule Of Bacterial Origin
Signal Transduction
Regulation Of Interleukin-6 Production
Toll-like Receptor 4 Signaling Pathway
Cell Surface Toll-like Receptor Signaling Pathway
Toll-like Receptor Signaling Pathway
Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Immature T Cell Proliferation In Thymus
Molecular Adaptor Activity
Cell Surface Pattern Recognition Receptor Signaling Pathway
Toll-like Receptor Binding
Response To Lipid
Heat Generation
Cellular Response To Lipid
Toll Signaling Pathway
Cytokine Activity
Cellular Response To Oxygen-containing Compound
Interleukin-33-mediated Signaling Pathway
Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Signal Transduction
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Chemokine Production
Extrinsic Component Of Plasma Membrane
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Signaling Adaptor Activity
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Tagcloud (Difference)
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Tagcloud (Intersection)
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