RNF26 and GMPS

Number of citations of the paper that reports this interaction (PubMedID 37519262)
92

Data Source:
BioGRID (pull down)

		RNF26	GMPS
Description		ring finger protein 26	guanine monophosphate synthase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding GMP Synthase Activity GMP Synthase (glutamine-hydrolyzing) Activity ATP Binding Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Endosome Organization Protein Ubiquitination Regulation Of Type I Interferon Production Negative Regulation Of Defense Response To Virus Protein K11-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm	Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process Purine Nucleobase Biosynthetic Process Purine Ribonucleoside Monophosphate Biosynthetic Process
Pathways			Purine ribonucleoside monophosphate biosynthesis Azathioprine ADME
Drugs			Glutamic acid
Diseases
GWAS		Platelet count ( 32888494) Refractive error ( 32231278)	Blood metabolite levels ( 27453504) Cardiorespiratory fitness (800m run time) ( 32572135)
Interacting Genes		54 interacting genes: ASCC3 CAPN15 CBR1 CCDC50 CTNND1 DDB1 DNAJC13 DOCK7 EEF1G EPS15 GMPS GSR GSTP1 HNRNPF HNRNPK HRNR HSPA5 HSPA8 HSPA9 IMMT INCA1 KEAP1 KRT1 KRT10 KRT2 KRT5 KRT6C MAP7D2 MYO6 PARP10 PRSS1 RBCK1 RCC2 RNF31 RPS27A SHARPIN SLC25A5 SQSTM1 TAX1BP1 TOLLIP TOM1L2 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2Q1 UBE2U UBE2W USP15 WRNIP1 YME1L1	6 interacting genes: AGPAT2 CEBPA FILNC1 RNF26 SUMO4 USP7
Entrez ID		79102	8833
HPRD ID		05842	10927
Ensembl ID		ENSG00000173456	ENSG00000163655
Uniprot IDs		Q9BY78	A0A140VJK6 P49915
PDB IDs			2VPI 2VXO
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Extracellular Exosome Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Catabolic Process Ubiquitin Binding Keratinization LUBAC Complex Cytosol Macromolecule Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Nucleotide Binding ATP Binding Protein Linear Polyubiquitination Structural Constituent Of Skin Epidermis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Organization Protein-macromolecule Adaptor Activity Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoplasm Peptide Cross-linking Protein Monoubiquitination Cornified Envelope Cellular Response To Interleukin-4 Regulation Of Canonical NF-kappaB Signal Transduction K63-linked Polyubiquitin Modification-dependent Protein Binding Protein Refolding Cellular Response To Stress Epidermis Development Response To Interleukin-4 Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Autophagosome Response To Stress Negative Regulation Of Fibroblast Proliferation
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