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TOLLIP and WRNIP1
Number of citations of the paper that reports this interaction (PMID
21903422
)
33
Data Source:
BioGRID
(affinity chromatography technology, pull down)
TOLLIP
WRNIP1
Gene Name
toll interacting protein
Werner helicase interacting protein 1
Image
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytosol
Nuclear Body
Interleukin-18 Receptor Complex
Interleukin-1 Receptor Complex
Perinuclear Region Of Cytoplasm
Extracellular Vesicular Exosome
Nucleus
Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
Signal Transducer Activity
Interleukin-1, Type I Receptor Binding
Protein Binding
Kinase Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Binding
SUMO Binding
Toll-like Receptor Binding
DNA Binding
Protein Binding
ATP Binding
ATPase Activity
Identical Protein Binding
Metal Ion Binding
Biological Process
Autophagy
Inflammatory Response
Signal Transduction
Cell-cell Signaling
Phosphorylation
Epithelial Cell Differentiation
Positive Regulation Of Protein Sumoylation
Intracellular Signal Transduction
Protein Localization To Endosome
Innate Immune Response
Leukocyte Activation
DNA Synthesis Involved In DNA Repair
DNA Replication
Regulation Of DNA-dependent DNA Replication Initiation
Pathways
Signaling by Interleukins
Cytokine Signaling in Immune system
Interleukin-1 signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions
38 interactors:
ATXN1
BHLHE40
CHD6
CPSF6
CSN1S1
CSN2
CSTF1
DAB1
DAZAP2
DZIP3
EIF2AK2
FTH1
HERPUD1
IL1R1
IL1RAP
IRAK1
IRAK2
LDB1
N4BP2
PEG10
PRR20A
RBFOX2
RBPMS
RHOXF2
SEPT1
SETDB1
SIAH1
TBX3
TLR2
TLR4
TOM1
TOM1L1
UBC
WDYHV1
WRNIP1
XRN2
ZBTB16
ZHX1
8 interactors:
ABL1
DDX58
PIN1
POLD1
POLD2
POLD4
TOLLIP
WRN
Entrez ID
54472
56897
HPRD ID
05887
10494
Ensembl ID
ENSG00000078902
ENSG00000124535
Uniprot IDs
B3KR28
B3KXC6
F2Z2Y8
Q6FIE9
Q9H0E2
Q96S55
PDB IDs
1WGL
3VHS
3VHT
Enriched GO Terms of Interacting Partners
?
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Toll-like Receptor 2 Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Kinase Activity
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Interleukin-1-mediated Signaling Pathway
Toll-like Receptor Signaling Pathway
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Protein Phosphorylation
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Transferase Activity
Positive Regulation Of Cellular Metabolic Process
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Activation Of Innate Immune Response
Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Activation Of Protein Kinase Activity
MyD88-independent Toll-like Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Toll-like Receptor 3 Signaling Pathway
Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleic Acid-templated Transcription
RNA Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
RNA Metabolic Process
Positive Regulation Of Protein Modification Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Innate Immune Response
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Regulation Of Protein Kinase Activity
Regulation Of Metabolic Process
Gene Expression
Regulation Of Phosphorylation
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Mismatch Repair
Base-excision Repair
Telomere Maintenance
Nucleotide-excision Repair, DNA Gap Filling
DNA-dependent DNA Replication
DNA Biosynthetic Process
Telomere Maintenance Via Semi-conservative Replication
Nuclear DNA Replication
Telomere Maintenance Via Recombination
Mitotic Recombination
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Telomere Maintenance Via Telomere Lengthening
Response To Stress
Transcription-coupled Nucleotide-excision Repair
DNA Repair
DNA Recombination
DNA Replication
Cellular Response To DNA Damage Stimulus
Nucleotide-excision Repair
DNA Metabolic Process
DNA Synthesis Involved In DNA Repair
Cell Cycle
Homeostatic Process
Cellular Response To Stimulus
Cellular Homeostasis
Cellular Response To Stress
Mitotic Cell Cycle
Innate Immune Response
Negative Regulation Of Type I Interferon Production
Negative Regulation Of ERK1 And ERK2 Cascade
Chromosome Organization
Response To Stimulus
Cell Cycle Process
DNA Replication Proofreading
Transitional One Stage B Cell Differentiation
Regulation Of Ubiquitin-protein Transferase Activity
Immune Response
Regulation Of Type I Interferon Production
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Defense Response
Regulation Of Cytokine Production
Negative Regulation Of Phospholipase C Activity
Mitochondrial Depolarization
Response To UV
Regulation Of Cell Motility
Regulation Of Growth Rate
Cellular Response To Dopamine
Nucleolus To Nucleoplasm Transport
RIG-I Signaling Pathway
Tagcloud
?
advance
comprehensively
doi
genotyped
haplotype
household
il18
il1b
il4
influences
kampala
nod2
nominal
online
persistently
publication
resistors
rstr
rstrs
slc6a3
snps
suggestively
tagging
tb
ticam2
tlr4
tlr6
tuberculin
uganda
Tagcloud (Difference)
?
advance
comprehensively
doi
genotyped
haplotype
household
il18
il1b
il4
influences
kampala
nod2
nominal
online
persistently
publication
resistors
rstr
rstrs
slc6a3
snps
suggestively
tagging
tb
ticam2
tlr4
tlr6
tuberculin
uganda
Tagcloud (Intersection)
?