TOLLIP and WRNIP1

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		TOLLIP	WRNIP1
Gene Name		toll interacting protein	Werner helicase interacting protein 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Body Interleukin-18 Receptor Complex Interleukin-1 Receptor Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Nucleus Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Signal Transducer Activity Interleukin-1, Type I Receptor Binding Protein Binding Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding SUMO Binding Toll-like Receptor Binding	DNA Binding Protein Binding ATP Binding ATPase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Autophagy Inflammatory Response Signal Transduction Cell-cell Signaling Phosphorylation Epithelial Cell Differentiation Positive Regulation Of Protein Sumoylation Intracellular Signal Transduction Protein Localization To Endosome Innate Immune Response Leukocyte Activation	DNA Synthesis Involved In DNA Repair DNA Replication Regulation Of DNA-dependent DNA Replication Initiation
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: ATXN1 BHLHE40 CHD6 CPSF6 CSN1S1 CSN2 CSTF1 DAB1 DAZAP2 DZIP3 EIF2AK2 FTH1 HERPUD1 IL1R1 IL1RAP IRAK1 IRAK2 LDB1 N4BP2 PEG10 PRR20A RBFOX2 RBPMS RHOXF2 SEPT1 SETDB1 SIAH1 TBX3 TLR2 TLR4 TOM1 TOM1L1 UBC WDYHV1 WRNIP1 XRN2 ZBTB16 ZHX1	8 interactors: ABL1 DDX58 PIN1 POLD1 POLD2 POLD4 TOLLIP WRN
Entrez ID		54472	56897
HPRD ID		05887	10494
Ensembl ID		ENSG00000078902	ENSG00000124535
Uniprot IDs		B3KR28 B3KXC6 F2Z2Y8 Q6FIE9 Q9H0E2	Q96S55
PDB IDs		1WGL	3VHS 3VHT
Enriched GO Terms of Interacting Partners?		Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 2 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Kinase Activity Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Activation Of Innate Immune Response Transcription, DNA-templated Negative Regulation Of Biosynthetic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Activation Of Protein Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Phosphorylation Toll-like Receptor 3 Signaling Pathway Regulation Of Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Innate Immune Response Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Metabolic Process Gene Expression Regulation Of Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter	Mismatch Repair Base-excision Repair Telomere Maintenance Nucleotide-excision Repair, DNA Gap Filling DNA-dependent DNA Replication DNA Biosynthetic Process Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Response To Stress Transcription-coupled Nucleotide-excision Repair DNA Repair DNA Recombination DNA Replication Cellular Response To DNA Damage Stimulus Nucleotide-excision Repair DNA Metabolic Process DNA Synthesis Involved In DNA Repair Cell Cycle Homeostatic Process Cellular Response To Stimulus Cellular Homeostasis Cellular Response To Stress Mitotic Cell Cycle Innate Immune Response Negative Regulation Of Type I Interferon Production Negative Regulation Of ERK1 And ERK2 Cascade Chromosome Organization Response To Stimulus Cell Cycle Process DNA Replication Proofreading Transitional One Stage B Cell Differentiation Regulation Of Ubiquitin-protein Transferase Activity Immune Response Regulation Of Type I Interferon Production Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Defense Response Regulation Of Cytokine Production Negative Regulation Of Phospholipase C Activity Mitochondrial Depolarization Response To UV Regulation Of Cell Motility Regulation Of Growth Rate Cellular Response To Dopamine Nucleolus To Nucleoplasm Transport RIG-I Signaling Pathway
Tagcloud ?		advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tuberculin uganda
Tagcloud (Difference) ?		advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tuberculin uganda
Tagcloud (Intersection) ?