RNF26 and CCDC50

Number of citations of the paper that reports this interaction (PubMedID 37519262)
92

Data Source:
BioGRID (pull down)

		RNF26	CCDC50
Description		ring finger protein 26	coiled-coil domain containing 50
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Cytoplasm Cytosol Ciliary Basal Body
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Endosome Organization Protein Ubiquitination Regulation Of Type I Interferon Production Negative Regulation Of Defense Response To Virus Protein K11-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm	Sensory Perception Of Sound
Pathways
Drugs
Diseases
GWAS		Platelet count ( 32888494) Refractive error ( 32231278)	Alzheimer's disease biomarkers ( 23562540) Lung cancer in never smokers ( 28604730)
Interacting Genes		54 interacting genes: ASCC3 CAPN15 CBR1 CCDC50 CTNND1 DDB1 DNAJC13 DOCK7 EEF1G EPS15 GMPS GSR GSTP1 HNRNPF HNRNPK HRNR HSPA5 HSPA8 HSPA9 IMMT INCA1 KEAP1 KRT1 KRT10 KRT2 KRT5 KRT6C MAP7D2 MYO6 PARP10 PRSS1 RBCK1 RCC2 RNF31 RPS27A SHARPIN SLC25A5 SQSTM1 TAX1BP1 TOLLIP TOM1L2 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2Q1 UBE2U UBE2W USP15 WRNIP1 YME1L1	14 interacting genes: ARRDC3 HNRNPA1 IFIH1 MAP1LC3B MAVS RIGI RIPK1 RNF26 RNF8 RPS3A SH3GL1 STING1 TNFAIP3 UBC
Entrez ID		79102	152137
HPRD ID		05842	06463
Ensembl ID		ENSG00000173456	ENSG00000152492
Uniprot IDs		Q9BY78	Q8IVM0
PDB IDs			6LAN
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Extracellular Exosome Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Catabolic Process Ubiquitin Binding Keratinization LUBAC Complex Cytosol Macromolecule Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Nucleotide Binding ATP Binding Protein Linear Polyubiquitination Structural Constituent Of Skin Epidermis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Organization Protein-macromolecule Adaptor Activity Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoplasm Peptide Cross-linking Protein Monoubiquitination Cornified Envelope Cellular Response To Interleukin-4 Regulation Of Canonical NF-kappaB Signal Transduction K63-linked Polyubiquitin Modification-dependent Protein Binding Protein Refolding Cellular Response To Stress Epidermis Development Response To Interleukin-4 Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Autophagosome Response To Stress Negative Regulation Of Fibroblast Proliferation	Regulation Of Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To DsRNA Cellular Response To Exogenous DsRNA Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Exogenous DsRNA Positive Regulation Of Interferon-beta Production Regulation Of Defense Response To Virus By Host Response To DsRNA Regulation Of Type I Interferon Production Ubiquitin Protein Ligase Binding Regulation Of Interferon-beta Production Pattern Recognition Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Innate Immune Response-activating Signaling Pathway Antiviral Innate Immune Response Activation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Intracellular Receptor Signaling Pathway Positive Regulation Of Defense Response Positive Regulation Of Interferon-alpha Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Defense Response To Virus By Host Identical Protein Binding Detection Of Virus Positive Regulation Of Innate Immune Response Regulation Of Interleukin-6 Production Single-stranded RNA Binding Immune Response-activating Signaling Pathway Regulation Of Type III Interferon Production Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Myeloid Dendritic Cell Cytokine Production MRNA Transcription Immune Response-regulating Signaling Pathway Positive Regulation Of Interleukin-8 Production Activation Of Immune Response Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Innate Immune Response Signaling Adaptor Activity Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Cytokine Production Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-6 Production Defense Response To Virus Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Immune System Process
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