RNF26 and CAPN15

Number of citations of the paper that reports this interaction (PubMedID 37519262)
92

Data Source:
BioGRID (pull down)

		RNF26	CAPN15
Description		ring finger protein 26	calpain 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Endosome Organization Protein Ubiquitination Regulation Of Type I Interferon Production Negative Regulation Of Defense Response To Virus Protein K11-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm	Proteolysis
Pathways			Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Platelet count ( 32888494) Refractive error ( 32231278)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		54 interacting genes: ASCC3 CAPN15 CBR1 CCDC50 CTNND1 DDB1 DNAJC13 DOCK7 EEF1G EPS15 GMPS GSR GSTP1 HNRNPF HNRNPK HRNR HSPA5 HSPA8 HSPA9 IMMT INCA1 KEAP1 KRT1 KRT10 KRT2 KRT5 KRT6C MAP7D2 MYO6 PARP10 PRSS1 RBCK1 RCC2 RNF31 RPS27A SHARPIN SLC25A5 SQSTM1 TAX1BP1 TOLLIP TOM1L2 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2Q1 UBE2U UBE2W USP15 WRNIP1 YME1L1	7 interacting genes: CPEB2 DAZAP2 RNF216 RNF26 SOX4 TRAF2 UBC
Entrez ID		79102	6650
HPRD ID		05842	07220
Ensembl ID		ENSG00000173456	ENSG00000103326
Uniprot IDs		Q9BY78	O75808
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Extracellular Exosome Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Catabolic Process Ubiquitin Binding Keratinization LUBAC Complex Cytosol Macromolecule Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Nucleotide Binding ATP Binding Protein Linear Polyubiquitination Structural Constituent Of Skin Epidermis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Organization Protein-macromolecule Adaptor Activity Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoplasm Peptide Cross-linking Protein Monoubiquitination Cornified Envelope Cellular Response To Interleukin-4 Regulation Of Canonical NF-kappaB Signal Transduction K63-linked Polyubiquitin Modification-dependent Protein Binding Protein Refolding Cellular Response To Stress Epidermis Development Response To Interleukin-4 Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Autophagosome Response To Stress Negative Regulation Of Fibroblast Proliferation	Mitogen-activated Protein Kinase Kinase Kinase Binding Post-translational Protein Modification Protein Polyubiquitination Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin Protein Ligase Activity Regulation Of Defense Response To Virus Macromolecule Catabolic Process TORC2 Complex Disassembly Negative Regulation Of Cytoplasmic Translational Elongation TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Modification-dependent Protein Catabolic Process Regulation Of Type I Interferon Production Ascending Aorta Morphogenesis Pro-B Cell Differentiation Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Atrial Septum Primum Morphogenesis Regulation Of Gene Expression Protein Modification Process CD27 Signaling Pathway Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Translational Elongation Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Noradrenergic Neuron Differentiation Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Mitral Valve Morphogenesis Regulation Of Cytokine Production Protein Localization To Perinuclear Region Of Cytoplasm Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Gamma-delta T Cell Activation Cellular Response To Oxygen-containing Compound Regulation Of Gamma-delta T Cell Differentiation Thioesterase Binding CD40 Receptor Complex CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Interleukin-17-mediated Signaling Pathway Catabolic Process Negative Regulation Of Cytoplasmic Translation Regulation Of Translational Elongation Lymphoid Progenitor Cell Differentiation Positive Regulation Of JUN Kinase Activity
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