RNF26 and RCC2

Number of citations of the paper that reports this interaction (PubMedID 37519262)
92

Data Source:
BioGRID (pull down)

		RNF26	RCC2
Description		ring finger protein 26	regulator of chromosome condensation 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Chromosome, Centromeric Region Nucleus Chromosome Nucleolus Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Membrane Midbody Early Endosome Membrane Chromosome, Centromeric Core Domain Mitotic Spindle Midzone
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Protein Kinase Binding Protein Domain Specific Binding Small GTPase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Endosome Organization Protein Ubiquitination Regulation Of Type I Interferon Production Negative Regulation Of Defense Response To Virus Protein K11-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm	Integrin-mediated Signaling Pathway Regulation Of Fibroblast Migration Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Migration Negative Regulation Of GTPase Activity Establishment Of Protein Localization Focal Adhesion Assembly Cell Division Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Chromosome Passenger Complex Localization To Kinetochore Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Ruffle Assembly
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Platelet count ( 32888494) Refractive error ( 32231278)	Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Non-melanoma skin cancer ( 29739929)
Interacting Genes		54 interacting genes: ASCC3 CAPN15 CBR1 CCDC50 CTNND1 DDB1 DNAJC13 DOCK7 EEF1G EPS15 GMPS GSR GSTP1 HNRNPF HNRNPK HRNR HSPA5 HSPA8 HSPA9 IMMT INCA1 KEAP1 KRT1 KRT10 KRT2 KRT5 KRT6C MAP7D2 MYO6 PARP10 PRSS1 RBCK1 RCC2 RNF31 RPS27A SHARPIN SLC25A5 SQSTM1 TAX1BP1 TOLLIP TOM1L2 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2Q1 UBE2U UBE2W USP15 WRNIP1 YME1L1	8 interacting genes: ANXA1 CEBPA ERG PRPF40A PTEN RAC1 RNF26 USP7
Entrez ID		79102	55920
HPRD ID		05842	18171
Ensembl ID		ENSG00000173456	ENSG00000179051
Uniprot IDs		Q9BY78	A0A024RAC5 Q9P258
PDB IDs			5GWN
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Extracellular Exosome Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Catabolic Process Ubiquitin Binding Keratinization LUBAC Complex Cytosol Macromolecule Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Nucleotide Binding ATP Binding Protein Linear Polyubiquitination Structural Constituent Of Skin Epidermis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Organization Protein-macromolecule Adaptor Activity Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Cytoplasm Peptide Cross-linking Protein Monoubiquitination Cornified Envelope Cellular Response To Interleukin-4 Regulation Of Canonical NF-kappaB Signal Transduction K63-linked Polyubiquitin Modification-dependent Protein Binding Protein Refolding Cellular Response To Stress Epidermis Development Response To Interleukin-4 Negative Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Autophagosome Response To Stress Negative Regulation Of Fibroblast Proliferation	Organelle Organization Regulation Of Cell Shape Regulation Of Ubiquitin-dependent Protein Catabolic Process Phagocytic Cup Regulation Of Cell Morphogenesis Protein Modification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Development Regulation Of Gene Expression Regulation Of Anatomical Structure Morphogenesis Cell Migration Macromolecule Metabolic Process Actin Filament Negative Regulation Of Cell Development Negative Regulation Of Transport Cytoskeleton Organization Cell Motility Regulation Of Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Proteolysis Response To Vitamin B2 C/EBP Complex Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Cell-substrate Junction Organization Regulation Of Focal Adhesion Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Hemopoiesis Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Endothelial Cell Migration Multicellular Organismal-level Homeostasis CHOP-C/EBP Complex PML Body Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Wound Healing Response To Glucocorticoid
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