TOLLIP and HERPUD1

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		TOLLIP	HERPUD1
Gene Name		toll interacting protein	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
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Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Body Interleukin-18 Receptor Complex Interleukin-1 Receptor Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Calcium Channel Complex Lewy Body Core
	Molecular Function	Signal Transducer Activity Interleukin-1, Type I Receptor Binding Protein Binding Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding SUMO Binding Toll-like Receptor Binding	Molecular_function Ion Channel Binding
	Biological Process	Autophagy Inflammatory Response Signal Transduction Cell-cell Signaling Phosphorylation Epithelial Cell Differentiation Positive Regulation Of Protein Sumoylation Intracellular Signal Transduction Protein Localization To Endosome Innate Immune Response Leukocyte Activation	Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Ubiquitination Positive Regulation Of Protein Binding Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling	ATF4 activates genes PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS			Cardiovascular disease risk factors ( 20838585) HDL cholesterol ( 20031564 23505323) Metabolic syndrome ( 20694148)
Protein-Protein Interactions		38 interactors: ATXN1 BHLHE40 CHD6 CPSF6 CSN1S1 CSN2 CSTF1 DAB1 DAZAP2 DZIP3 EIF2AK2 FTH1 HERPUD1 IL1R1 IL1RAP IRAK1 IRAK2 LDB1 N4BP2 PEG10 PRR20A RBFOX2 RBPMS RHOXF2 SEPT1 SETDB1 SIAH1 TBX3 TLR2 TLR4 TOM1 TOM1L1 UBC WDYHV1 WRNIP1 XRN2 ZBTB16 ZHX1	16 interactors: AMFR APP ARHGDIA CD3D CD58 EWSR1 IMPA2 PSEN1 RPA2 STARD9 TOLLIP UBE2G2 UBQLN2 USP7 VCP XRCC6
Entrez ID		54472	9709
HPRD ID		05887	07456
Ensembl ID		ENSG00000078902	ENSG00000051108
Uniprot IDs		B3KR28 B3KXC6 F2Z2Y8 Q6FIE9 Q9H0E2	A4UAE9 Q15011 Q53FP9
PDB IDs		1WGL	1WGD
Enriched GO Terms of Interacting Partners?		Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 2 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Kinase Activity Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Activation Of Innate Immune Response Transcription, DNA-templated Negative Regulation Of Biosynthetic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Activation Of Protein Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Phosphorylation Toll-like Receptor 3 Signaling Pathway Regulation Of Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Innate Immune Response Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Metabolic Process Gene Expression Regulation Of Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter	Smooth Endoplasmic Reticulum Calcium Ion Homeostasis ER-associated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Stimulus Response To Stress Double-strand Break Repair Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Movement Of Cell Or Subcellular Component Endoplasmic Reticulum Calcium Ion Homeostasis Cellular Response To Stress Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Differentiation Regulation Of Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Transcription-coupled Nucleotide-excision Repair Cellular Protein Catabolic Process Response To Stimulus DNA Repair Protein Catabolic Process Learning Or Memory Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Regulation Of Proteolysis Cellular Component Assembly Negative Regulation Of Axonogenesis Cajal-Retzius Cell Differentiation Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Beta-amyloid Formation Cell Activation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cognition Negative Regulation Of Neurogenesis Neuron Death Positive Regulation Of Proteolysis Regulation Of Neurogenesis Cellular Response To Heat Positive Regulation Of Proteasomal Protein Catabolic Process Immune Response Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Glycosylation Macromolecule Glycosylation Negative Regulation Of Cell Development Telomere Maintenance Regulation Of ERBB Signaling Pathway
Tagcloud ?		advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tuberculin uganda	ankrd1 ccl13 ccl3l3 ccl7 ccl9 csda dbq1 egr3 gadd45g gstm2 hsp90aa hspa1a hspd1 hsph1 mgst3 mybpc3 myh7 myom2 nfkbid nppa opioidergic ptgds saa1 sarcomeric selp serpina3 serpinh1 slp xirp1
Tagcloud (Difference) ?		advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tuberculin uganda	ankrd1 ccl13 ccl3l3 ccl7 ccl9 csda dbq1 egr3 gadd45g gstm2 hsp90aa hspa1a hspd1 hsph1 mgst3 mybpc3 myh7 myom2 nfkbid nppa opioidergic ptgds saa1 sarcomeric selp serpina3 serpinh1 slp xirp1
Tagcloud (Intersection) ?