TOLLIP and CSN1S1

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		TOLLIP	CSN1S1
Gene Name		toll interacting protein	casein alpha s1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Body Interleukin-18 Receptor Complex Interleukin-1 Receptor Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Signal Transducer Activity Interleukin-1, Type I Receptor Binding Protein Binding Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding SUMO Binding Toll-like Receptor Binding	Transporter Activity
	Biological Process	Autophagy Inflammatory Response Signal Transduction Cell-cell Signaling Phosphorylation Epithelial Cell Differentiation Positive Regulation Of Protein Sumoylation Intracellular Signal Transduction Protein Localization To Endosome Innate Immune Response Leukocyte Activation	Transport
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: ATXN1 BHLHE40 CHD6 CPSF6 CSN1S1 CSN2 CSTF1 DAB1 DAZAP2 DZIP3 EIF2AK2 FTH1 HERPUD1 IL1R1 IL1RAP IRAK1 IRAK2 LDB1 N4BP2 PEG10 PRR20A RBFOX2 RBPMS RHOXF2 SEPT1 SETDB1 SIAH1 TBX3 TLR2 TLR4 TOM1 TOM1L1 UBC WDYHV1 WRNIP1 XRN2 ZBTB16 ZHX1	11 interactors: CSNK2A1 CSNK2B HTRA2 PARK7 PLK1 PPM1J PRSS2 SAP130 STK4 TOLLIP TTBK1
Entrez ID		54472	1446
HPRD ID		05887	00280
Ensembl ID		ENSG00000078902	ENSG00000126545
Uniprot IDs		B3KR28 B3KXC6 F2Z2Y8 Q6FIE9 Q9H0E2	P47710
PDB IDs		1WGL
Enriched GO Terms of Interacting Partners?		Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 2 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Kinase Activity Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Activation Of Innate Immune Response Transcription, DNA-templated Negative Regulation Of Biosynthetic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Activation Of Protein Kinase Activity MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Phosphorylation Toll-like Receptor 3 Signaling Pathway Regulation Of Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Protein Modification Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Innate Immune Response Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Metabolic Process Gene Expression Regulation Of Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter	Positive Regulation Of Protein Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Regulation Of Binding Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Cellular Protein Modification Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Catabolic Process Peptidyl-serine Phosphorylation Positive Regulation Of Protein Modification Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Binding Regulation Of Protein Sumoylation Peptidyl-amino Acid Modification Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Toxic Substance Negative Regulation Of Oxidative Stress-induced Cell Death Phosphorylation Phosphate-containing Compound Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Growth Positive Regulation Of Signal Transduction Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Proteolysis Protein Phosphorylation Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Cell Death Positive Regulation Of Protein Binding Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tuberculin uganda	0x 1x 25x 2x 4ebp1 4x 5x 8x arg arginine bovine casein conditionally csn2 csn3 devoid except excess experimental gland mammary mtor output resemble s6k stat5 true
Tagcloud (Difference) ?		advance comprehensively doi genotyped haplotype household il18 il1b il4 influences kampala nod2 nominal online persistently publication resistors rstr rstrs slc6a3 snps suggestively tagging tb ticam2 tlr4 tlr6 tuberculin uganda	0x 1x 25x 2x 4ebp1 4x 5x 8x arg arginine bovine casein conditionally csn2 csn3 devoid except excess experimental gland mammary mtor output resemble s6k stat5 true
Tagcloud (Intersection) ?