POR and CYB5A

Number of citations of the paper that reports this interaction (PMID 9398194)
26

Data Source:
HPRD (in vitro)

		POR	CYB5A
Gene Name		P450 (cytochrome) oxidoreductase	cytochrome b5 type A (microsomal)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	NADPH-hemoprotein Reductase Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Iron Ion Binding Protein Binding Nitric Oxide Dioxygenase Activity Electron Carrier Activity FMN Binding Hydrolase Activity Enzyme Binding Iron-cytochrome-c Reductase Activity Flavin Adenine Dinucleotide Binding NADP Binding	Aldo-keto Reductase (NADP) Activity Cytochrome-c Oxidase Activity Enzyme Binding Heme Binding Metal Ion Binding
	Biological Process	Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Response To Nutrient Carnitine Metabolic Process Flavonoid Metabolic Process Internal Peptidyl-lysine Acetylation Fatty Acid Oxidation Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Monooxygenase Activity Response To Drug Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nitrate Catabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Smoothened Signaling Pathway Nitric Oxide Catabolic Process Oxidation-reduction Process Negative Regulation Of Lipase Activity Demethylation Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Steroid Hormone Biosynthetic Process Cellular Organofluorine Metabolic Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process L-ascorbic Acid Metabolic Process Small Molecule Metabolic Process Response To Cadmium Ion Oxidation-reduction Process Hydrogen Ion Transmembrane Transport
Pathways			Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Vitamin C (ascorbate) metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs		Flavin-Adenine Dinucleotide Riboflavin Monophosphate 2\'-Monophosphoadenosine 5\'-Diphosphoribose	Heme Dimethyl Propionate Ester Heme
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CYB5A CYP17A1 CYP1A2 CYP2A6 CYP2C19 CYP2C9 CYP2D6 CYP2E1 CYP3A4 FANCC HMOX1 RABEPK STAT1 XRCC6	15 interactors: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 CYP4F2 POR SCD UGT1A4
Entrez ID		5447	1528
HPRD ID		00485	08941
Ensembl ID		ENSG00000127948	ENSG00000166347
Uniprot IDs		E7EVY7 F5H468 P16435	P00167
PDB IDs		1B1C 3FJO 3QE2 3QFC 3QFR 3QFS 3QFT	2I96
Enriched GO Terms of Interacting Partners?		Monoterpenoid Metabolic Process Exogenous Drug Catabolic Process Drug Catabolic Process Drug Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Epoxygenase P450 Pathway Steroid Metabolic Process Arachidonic Acid Metabolic Process Response To Drug Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Isoprenoid Metabolic Process Oxidative Demethylation Oxidation-reduction Process Omega-hydroxylase P450 Pathway Fatty Acid Metabolic Process Alkaloid Metabolic Process Carboxylic Acid Metabolic Process Demethylation Small Molecule Metabolic Process Organic Acid Metabolic Process Response To Inorganic Substance Lipid Metabolic Process Monocarboxylic Acid Metabolic Process Cellular Lipid Metabolic Process Alkaloid Catabolic Process Catabolic Process Response To Reactive Oxygen Species Heterocycle Metabolic Process Response To Cadmium Ion Response To Stimulus Coumarin Metabolic Process Cellular Response To Stimulus Dibenzo-p-dioxin Metabolic Process Cellular Response To Cadmium Ion Response To Oxidative Stress Steroid Catabolic Process Cellular Metabolic Process Androgen Metabolic Process Porphyrin-containing Compound Metabolic Process Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Cellular Organofluorine Metabolic Process Negative Regulation Of Macrophage Fusion Oxidative Deethylation Response To Acetate Toxin Biosynthetic Process Response To Lipopolysaccharide	Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Drug Metabolic Process Epoxygenase P450 Pathway Oxidation-reduction Process Exogenous Drug Catabolic Process Organic Acid Metabolic Process Small Molecule Metabolic Process Drug Catabolic Process Arachidonic Acid Metabolic Process Carboxylic Acid Metabolic Process Fatty Acid Metabolic Process Icosanoid Metabolic Process Monocarboxylic Acid Metabolic Process Unsaturated Fatty Acid Metabolic Process Lipid Metabolic Process Long-chain Fatty Acid Metabolic Process Steroid Metabolic Process Monoterpenoid Metabolic Process Response To Drug Omega-hydroxylase P450 Pathway Catabolic Process Cellular Lipid Metabolic Process Demethylation Coumarin Metabolic Process Isoprenoid Metabolic Process Dibenzo-p-dioxin Metabolic Process Alkaloid Metabolic Process Toxin Metabolic Process Oxidative Demethylation Flavonoid Metabolic Process Vitamin Metabolic Process Alkaloid Catabolic Process Pressure Natriuresis Leukotriene B4 Catabolic Process Cellular Metabolic Process Cellular Response To Stimulus Porphyrin-containing Compound Metabolic Process Positive Regulation Of Steroid Hormone Biosynthetic Process Long-chain Fatty Acid Catabolic Process Response To Herbicide Heterocycle Metabolic Process Hydrogen Peroxide Biosynthetic Process Lipid Catabolic Process Cellular Ketone Metabolic Process Positive Regulation Of Hormone Biosynthetic Process Tetrapyrrole Metabolic Process Lipid Biosynthetic Process Vitamin D Metabolic Process
Tagcloud ?		5c 7h adjuvant aluminiumphosphate bactericidal class deoxycholate donors engineered extraction final formulated genetically meningococcal mixed omps omv outer p1 pora prepared represent safe serogroup served strains vaccine vaccines vesicles	administering anxa1 c4bpalpha cox2 cpla2alpha crip1 ctsl1 endorses eva1 gstp1 hgd il6st interferes levonorgestrel lng loc90133 maoa mifepristone ovulatory paep receptive receptivity s100a4 sat1 serpinb9 slc25a29 slc39a14 tgm2 unproven
Tagcloud (Difference) ?		5c 7h adjuvant aluminiumphosphate bactericidal class deoxycholate donors engineered extraction final formulated genetically meningococcal mixed omps omv outer p1 pora prepared represent safe serogroup served strains vaccine vaccines vesicles	administering anxa1 c4bpalpha cox2 cpla2alpha crip1 ctsl1 endorses eva1 gstp1 hgd il6st interferes levonorgestrel lng loc90133 maoa mifepristone ovulatory paep receptive receptivity s100a4 sat1 serpinb9 slc25a29 slc39a14 tgm2 unproven
Tagcloud (Intersection) ?