POR and CYP1A2

Number of citations of the paper that reports this interaction (PubMedID 15680923)
0

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		POR	CYP1A2
Description		cytochrome p450 oxidoreductase	cytochrome P450 family 1 subfamily A member 2
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Intracellular Membrane-bounded Organelle	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	NADPH-hemoprotein Reductase Activity Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding Enzyme Activator Activity Nitric Oxide Dioxygenase NAD(P)H Activity Electron Transfer Activity FMN Binding Oxidoreductase Activity Hydrolase Activity Enzyme Binding Iron-cytochrome-c Reductase Activity Flavin Adenine Dinucleotide Binding NADP Binding	Monooxygenase Activity Iron Ion Binding Protein Binding Steroid Hydroxylase Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity Enzyme Binding Heme Binding Demethylase Activity Caffeine Oxidase Activity Metal Ion Binding Estrogen 16-alpha-hydroxylase Activity Estrogen 2-hydroxylase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity
	Biological Process	Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Response To Nutrient Response To Xenobiotic Stimulus Carnitine Metabolic Process Response To Hormone Flavonoid Metabolic Process Fatty Acid Oxidation Electron Transport Chain Positive Regulation Of Chondrocyte Differentiation Negative Regulation Of Apoptotic Process Nitrate Catabolic Process Positive Regulation Of Smoothened Signaling Pathway Nitric Oxide Catabolic Process Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Demethylation Cellular Response To Gonadotropin Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Response To Dexamethasone Positive Regulation Of Steroid Hormone Biosynthetic Process Organofluorine Metabolic Process	Lipid Metabolic Process Fatty Acid Metabolic Process Steroid Catabolic Process Porphyrin-containing Compound Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Estrogen Metabolic Process Toxin Biosynthetic Process Toxin Metabolic Process Post-embryonic Development Alkaloid Metabolic Process Regulation Of Gene Expression Monoterpenoid Metabolic Process Dibenzo-p-dioxin Metabolic Process Arachidonate Metabolic Process Epoxygenase P450 Pathway Lung Development Methylation Monocarboxylic Acid Metabolic Process Xenobiotic Catabolic Process Hormone Metabolic Process Retinol Metabolic Process Long-chain Fatty Acid Biosynthetic Process Cellular Respiration Aflatoxin Metabolic Process Hydrogen Peroxide Biosynthetic Process Oxidative Demethylation Cellular Response To Cadmium Ion Omega-hydroxylase P450 Pathway Olefinic Compound Metabolic Process
Pathways		Cytochrome P450 - arranged by substrate type	Methylation Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Aflatoxin activation and detoxification Biosynthesis of protectins Biosynthesis of maresin-like SPMs
Drugs		Flavin adenine dinucleotide Flavin mononucleotide Nicotinamide adenine dinucleotide phosphate	Isoniazid alpha-Naphthoflavone Cannabidiol Diacerein Nabiximols
Diseases		46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Coffee consumption ( 25288136 31959922 31046077) Coffee consumption (cups per day) ( 31837886 25288136) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31451708) High light scatter reticulocyte count ( 32888494) Low density lipoprotein cholesterol levels ( 32154731) Metabolite levels ( 23823483) Platelet count ( 32888494) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Reticulocyte count ( 32888494) Urinary albumin-to-creatinine ratio ( 31511532)	Bladder cancer ( 25281661) Caffeine consumption ( 21490707) Coffee consumption ( 21357676 21876539 25288136 31959922) Coffee consumption (cups per day) ( 25288136) Diastolic blood pressure ( 19430483) Lung cancer ( 28604730) Mean arterial pressure ( 27618448) Plasma clozapine levels in treatment-resistant schizophrenia ( 30922102) Red blood cell count ( 27863252 32888494) Serum albumin levels ( 29403010) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		15 interacting genes: CYB5A CYP17A1 CYP1A2 CYP2A6 CYP2C19 CYP2C9 CYP2D6 CYP2E1 CYP3A4 FANCC HMOX1 LINC01554 RABEPK STAT1 XRCC6	3 interacting genes: ABHD16A CYB5A POR
Entrez ID		5447	1544
HPRD ID		00485	00489
Ensembl ID		ENSG00000127948	ENSG00000140505
Uniprot IDs		A0A9L9PY49 P16435	P05177
PDB IDs		1B1C 3FJO 3QE2 3QFC 3QFR 3QFS 3QFT 5EMN 5FA6	2HI4
Enriched GO Terms of Interacting Partners?		Monoterpenoid Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Heme Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Xenobiotic Catabolic Process Iron Ion Binding Olefinic Compound Metabolic Process Intracellular Membrane-bounded Organelle Epoxygenase P450 Pathway Steroid Hydroxylase Activity Arachidonate Metabolic Process Long-chain Fatty Acid Metabolic Process Xenobiotic Metabolic Process Oxidative Demethylation Steroid Metabolic Process Demethylation Long-chain Fatty Acid Biosynthetic Process Terpenoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Icosanoid Metabolic Process Isoprenoid Metabolic Process Oxidoreductase Activity Caffeine Oxidase Activity Enzyme Binding Oxygen Binding Fatty Acid Metabolic Process Estrogen Metabolic Process Estrogen 2-hydroxylase Activity Endoplasmic Reticulum Membrane Alkaloid Metabolic Process Omega-hydroxylase P450 Pathway Arachidonate Epoxygenase Activity Secondary Metabolic Process Fatty Acid Biosynthetic Process Monocarboxylic Acid Metabolic Process (S)-limonene 7-monooxygenase Activity (R)-limonene 6-monooxygenase Activity (S)-limonene 6-monooxygenase Activity Anandamide 8,9 Epoxidase Activity Anandamide 11,12 Epoxidase Activity Anandamide 14,15 Epoxidase Activity Hormone Metabolic Process Endoplasmic Reticulum Coumarin Metabolic Process Alkaloid Catabolic Process Long-chain Fatty Acid Omega-1 Hydroxylase Activity Cholesterol Metabolic Process Carboxylic Acid Biosynthetic Process Small Molecule Biosynthetic Process	Flavonoid Metabolic Process Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Enzyme Binding Intracellular Membrane-bounded Organelle Heme Binding Oxidoreductase Activity, Acting On Diphenols And Related Substances As Donors Xenobiotic Metabolic Process Flavonoid 3'-monooxygenase Activity Lipid Modification Dibenzo-p-dioxin Catabolic Process Response To 3-methylcholanthrene Vitamin D 24-hydroxylase Activity Arachidonate Monooxygenase Activity Response To Nutrient Insecticide Metabolic Process Response To Diphenyl Ether Ethylene Metabolic Process Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Nitric Oxide Catabolic Process Organofluorine Metabolic Process Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Modified Amino Acid Metabolic Process Dibenzo-p-dioxin Metabolic Process Coumarin Metabolic Process Nitrate Metabolic Process NADPH-hemoprotein Reductase Activity Endoplasmic Reticulum Membrane Lipid Metabolic Process Response To Genistein 9-cis-retinoic Acid Biosynthetic Process Response To Aroclor 1254 Response To Iron(III) Ion Demethylase Activity Response To Ketone Long-chain Fatty Acid Omega-1 Hydroxylase Activity Maternal Process Involved In Parturition Response To Herbicide Response To Hydroxyisoflavone Positive Regulation Of Steroid Hormone Biosynthetic Process Monoacylglycerol Catabolic Process Long-chain Fatty Acid Omega-hydroxylase Activity Lipid Hydroxylation Lipid Catabolic Process Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Response To Phenylpropanoid
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